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Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

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Abstract
There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
Keywords
ENDOPLASMIC-RETICULUM STRESS, NF-KAPPA-B, ACUTE LUNG INJURY, RESPIRATORY, SYNDROME CORONAVIRUS, MUSCLE-CELL PROLIFERATION, OXIDATIVE STRESS, INSULIN-RESISTANCE, SIGNALING PATHWAY, NRF2 ACTIVATORS, SULFORAPHANE, PROTECTS, COVID-19, Nrf2, Foods, Nutrients, Insulin resistance, Obesity, TRPA1

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MLA
Bousquet, Jean, et al. “Nrf2-Interacting Nutrients and COVID-19 : Time for Research to Develop Adaptation Strategies.” CLINICAL AND TRANSLATIONAL ALLERGY, vol. 10, no. 1, 2020, doi:10.1186/s13601-020-00362-7.
APA
Bousquet, J., Cristol, J.-P., Czarlewski, W., Anto, J. M., Martineau, A., Haahtela, T., … Zubrinich, C. (2020). Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies. CLINICAL AND TRANSLATIONAL ALLERGY, 10(1). https://doi.org/10.1186/s13601-020-00362-7
Chicago author-date
Bousquet, Jean, Jean-Paul Cristol, Wienczyslawa Czarlewski, Josep M. Anto, Adrian Martineau, Tari Haahtela, Susana C. Fonseca, et al. 2020. “Nrf2-Interacting Nutrients and COVID-19 : Time for Research to Develop Adaptation Strategies.” CLINICAL AND TRANSLATIONAL ALLERGY 10 (1). https://doi.org/10.1186/s13601-020-00362-7.
Chicago author-date (all authors)
Bousquet, Jean, Jean-Paul Cristol, Wienczyslawa Czarlewski, Josep M. Anto, Adrian Martineau, Tari Haahtela, Susana C. Fonseca, Guido Iaccarino, Hubert Blain, Alessandro Fiocchi, G. Walter Canonica, Joao A. Fonseca, Alain Vidal, Hak-Jong Choi, Hyun Ju Kim, Vincent Le Moing, Jacques Reynes, Aziz Sheikh, Cezmi A. Akdis, Torsten Zuberbier, Amir Hamzah Abdul Latiff, Baharudin Abdullah, Werner Aberer, Nancy Abusada, Ian Adcock, Alejandro Afani, Ioana Agache, Xenofon Aggelidis, Jenifer Agustin, Cezmi A. Akdis, Mubeccel Akdis, Mona Al-Ahmad, Abou Al-Zahab Bassam, Hussam Alburdan, Oscar Aldrey-Palacios, Emilio Alvarez Cuesta, Hiba Alwan Salman, Ashraf Alzaabi, Salma Amade, Gene Ambrocio, Rosana Angles, Isabella Annesi-Maesano, Ignacio J. Ansotegui, Josep M. Anto, Paula Ara Bardajo, Stefania Arasi, Margarete Arrais, Hasan Arshad, Maria-Cristina Artesani, Estrella Asayag, Francesca Avolio, Khuzama Azhari, Claus Bachert, Diego Bagnasco, Ilaria Baiardini, Nissera Bajrovic, Petros Bakakos, Sergio Bakeyala Mongono, Christine Balotro-Torres, Sergio Barba, Cristina Barbara, Elsa Barbosa, Bruno Barreto, Joan Bartra, Xavier Basagana, Eric D. Bateman, Lkhagvaa Battur, Anna Bedbrook, Martin Bedolla Barajas, Bianca Beghe, Antra Bekere, Elizabeth Bel, Ali Ben Kheder, Mikael Benson, Elena-Camelia Berghea, Karl-Christian Bergmann, Roberto Bernardini, David Bernstein, Mike Bewick, Slawomir Bialek, Artur Bialoszewski, Thomas Bieber, Nils E. Billo, Maria-Beatrice Bilo, Carsten Bindslev-Jensen, Leif Bjermer, Hubert Blain, Irina Bobolea, Malgorzata Bochenska Marciniak, Christine Bond, Attilio Boner, Matteo Bonini, Sergio Bonini, Sinthia Bosnic-Anticevich, Isabelle Bosse, Sofia Botskariova, Jacques Bouchard, Louis-Philippe Boulet, Rodolphe Bourret, Philippe Bousquet, Fulvio Braido, Andrew Briggs, Christopher E. Brightling, Jan Brozek, Luisa Brussino, Roland Buhl, Roxana Bumbacea, Rosalva Buquicchio, Maria-Teresa Burguete Cabanas, Andrew Bush, William W. Busse, Jeroen Buters, Fernan Caballero-Fonseca, Moises A. Calderon, Mario Calvo, Paulo Camargos, Thierry Camuzat, F. R. Canevari, Antonio Cano, G. Walter Canonica, Arnaldo Capriles-Hulett, Luis Caraballo, Vicky Cardona, Kai-Hakon Carlsen, Jonas Carmona Pirez, Jorge Caro, Warner Carr, Pedro Carreiro-Martins, Fredelita Carreon-Asuncion, Ana-Maria Carriazo, Carme Carrion y Ribas, Thomas Casale, Mary-Ann Castor, Elizabeth Castro, A. G. Caviglia, Lorenzo Cecchi, Alfonso Cepeda Sarabia, Maciej Chalubinski, Ramanathan Chandrasekharan, Yoon-Seok Chang, Victoria Chato-Andeza, Lida Chatzi, Christina Chatzidaki, Niels H. Chavannes, Claudia Chaves Loureiro, Aurora-Alejandra Chavez Garcia, Marta Chelninska, Yuzhi Chen, Lei Cheng, Sharon Chinthrajah, Tomas Chivato, Ekaterine Chkhartishvili, George Christoff, Henry Chrystyn, Derek K. Chu, Antonio Chua, Alexander Chuchalin, Kian Fan Chung, Alberto Ciceran, Cemal Cingi, Giorgio Ciprandi, Ieva Cirule, Ana-Carla Coelho, Enrico Compalati, Jannis Constantinidis, Jaime Correia de Sousa, Elisio Manuel Costa, David Costa, Maria del Carmen Costa Dominguez, Andre Coste, M. Cottini, Linda Cox, Carlos Crisci, Maria Angiola Crivellaro, Alvaro A. Cruz, John Cullen, Adnan Custovic, Biljana Cvetkovski, Wienczyslawa Czarlewski, Gennaro D’Amato, Jane da Silva, Ronald Dahl, Sven-Erik Dahlen, Vasilis Daniilidis, Louei Darjazini Nahhas, Ulf Darsow, Janet Davies, Frederic de Blay, Giulia De Feo, Eloisa De Guia, Jose-Ricardo de la Torre Navarrete, Chato de los Santos, Esteban De Manuel Keenoy, Govert De Vries, Diana Deleanu, Pascal Demoly, Judah Denburg, Philippe Devillier, Alain Didier, Sanja Dimic Janjic, Maria Dimou, Anh Tuan Dinh-Xuan, Ratko Djukanovic, Maria Do Ceu Texeira, Dejan Dokic, Margarita Gabriela Dominguez Silva, Habib Douagui, Nikolaos Douladiris, Maria Doulaptsi, Gerard Dray, Ruta Dubakiene, Eve Dupas, Stephen Durham, Marzia Duse, Mark Dykewicz, Didier Ebo, Natalija Edelbaher, Thomas Eiwegger, Patrik Eklund, Yehia El-Gamal, Zeinab A. El-Sayed, Shereen S. El-Sayed, Magda El-Seify, Regina Emuzyte, Lourdes Enecilla, Marina Erhola, Heidilita Espinoza, Jesus Guillermo Espinoza Contreras, John Farrell, Lenora Fernandez, Paola Fimbres Jimenez, Antje Fink Wagner, Alessandro Fiocchi, Wytske J. Fokkens, Lenia Folletti, Joao A. Fonseca, Jean-Francois Fontaine, Francesco Forastiere, Jose Miguel Fuentes Perez, Emily Gaerlan-Resureccion, Mina Gaga, Jose Luis Galvez Romero, Amiran Gamkrelidze, Alexis Garcia, Cecilia Yvonne Garcia Cobas, Maria de la Luz Hortensia Garcia Cruz, Valeria Garcia Ortiz, Jacques Gayraud, Matteo Gelardi, Bilun Gemicioglu, Dimitra Gennimata, Sonya Genova, Jose Gereda, Roy Gerth van Wijk, Antonio Giuliano, Rene-Maximiliano Gomez, Miguel-Ange Gonzalez Ballester, Sandra Gonzalez Diaz, Maia Gotua, Christos Grigoreas, Ineta Grisle, Marta Guidacci, Nick Guldemond, Zdenek Gutter, Antonieta Guzman, Tari Haahtela, Ramsa Halloum, David Halpin, Eckard Hamelmann, Suleiman Hammadi, Richard Harvey, Enrico Heffler, Joachim Heinrich, Adnan Hejjaoui, Birthe Hellquist-Dahl, Luiana Hernandez Velazquez, Mark Hew, Elham Hossny, Peter Howarth, Martin Hrubisko, Yunuen Rocio Huerta Villalobos, Marc Humbert, Salina Husain, Michael Hyland, Guido Iaccarino, Moustafa Ibrahim, Nataliya Ilina, Maddalena Illario, Cristoforo Incorvaia, Antonio Infantino, Carla Irani, Zhanat Ispayeva, Juan Carlos Ivancevich, Edgardo E. J. Jares, Deborah Jarvis, Ewa Jassem, Klemen Jenko, Ruben Dario Jimeneracruz Uscanga, Sebastian L. Johnston, Guy Joos, Maja Jost, Kaja Julge, Ki-Suck Jung, Jocelyne Just, Marek Jutel, Igor Kaidashev, Omer Kalayci, Fuat Kalyoncu, Jeni Kapsali, Przemyslaw Kardas, Jussi Karjalainen, Carmela A. Kasala, Michael Katotomichelakis, Loreta Kavaliukaite, Kazi S. Bennoor, Thomas Keil, Paul Keith, Musa Khaitov, Nikolai Khaltaev, You-Young Kim, Bruce Kirenga, Jorg Kleine-Tebbe, Ludger Klimek, Fanny W. Ko, Bernard Koffi N’Goran, Evangelia Kompoti, Peter Kopac, Gerard Koppelman, Anja Koren Jeverica, Seppo Koskinen, Mitja Kosnik, Tomasz Kostka, Kosta V. Kostov, Marek L. Kowalski, Tanya Kralimarkova, Karmen Kramer Vrscaj, Helga Kraxner, Samo Kreft, Vicky Kritikos, Dmitry Kudlay, Mikael Kuitunen, Inger Kull, Piotr Kuna, Maciej Kupczyk, Violeta Kvedariene, Marialena Kyriakakou, Nika Lalek, Massimo Landi, Stephen Lane, Desiree E. Larenas-Linnemann, Susanne Lau, Daniel Laune, Jorge Lavrut, Lan Le, Martina Lenzenhuber, Gualtiero Leo, Marcus Lessa, Michael Levin, Jing Li, Philip Lieberman, Giuseppe Liotta, Brian Lipworth, Xuandao Liu, Rommel Lobo, Karin C. Lodrup Carlsen, Carlo Lombardi, Renaud Louis, Stelios Loukidis, Olga Lourenco, Jorge A. Luna Pech, Bojan Madjar, Enrico Maggi, Antoine Magnan, Bassam Mahboub, Alpana Mair, Anke-Hilse Maitland van der Zee, Mika Makela, Michael Makris, Hans-Jorgen Malling, Mariana Mandajieva, Patrick Manning, Manolis Manousakis, Pavlos Maragoudakis, Gianluigi Marseglia, Gailen Marshall, Mohammad Reza Masjedi, Jorge F. Maspero, Juan Jose Matta Campos, Marcus Maurer, Sandra Mavale-Manuel, Cem Meco, Erik Melen, Giovanni Melioli, Elisabete Melo-Gomes, Eli O. Meltzer, Enrica Menditto, Andrew Menzies-Gow, Hans Merk, Jean-Pierre Michel, Yann Micheli, Neven Miculinic, Luis Midao, Florin Mihaltan, Nikolaos Mikos, Manlio Milanese, Branislava Milenkovic, Dimitrios Mitsias, Bassem Moalla, Giuliana Moda, Maria Dolores Mogica Martinez, Yousser Mohammad, Frances-Montserrat Moharra, Mostafa Moin, Mathieu Molimard, Isabelle Momas, Monique Mommers, Alessandro Monaco, Stephen Montefort, Lucia-Elvira Montenegro, Riccardo Monti, Dory Mora, Mario Morais-Almeida, Ralph Mosges, Badr Eldin Mostafa, Joaquim Mullol, Lars Munter, Antonella Muraro, Ruth Murray, Antonio Musarra, Tihomir Mustakov, Robert Naclerio, Kari C. Nadeau, Rachel Nadif, Alla Nakonechna, Leyla Namazova-Baranova, Gretchen Navarro-Locsin, Hugo Neffen, Kristof Nekam, Angelos Neou, Eustachio Nettis, Daniel Neuberger, Laurent Nicod, Stefania Nicola, Verena Niederberger-Leppin, Marek Niedoszytko, Antonio Nieto, Ettore Novellino, Elizabete Nunes, Dieudonne Nyembue, Robyn E. O’Hehir, Cvetanka Odjakova, Ken Ohta, Yoshitaka Okamoto, Kimi Okubo, Brian Oliver, Gabrielle L. Onorato, Maria Pia Orru, Solange Ouedraogo, Kampadilemba Ouoba, Francisco-Javier Padilla, Pier Luigi Paggiaro, Aris Pagkalos, Giovanni Pajno, Gianni Pala, S. P. Palaniappan, Isabella Pali-Scholl, Susanna Palkonen, Stephen Palmer, Carmen Panaitescu Bunu, Petr Panzner, Nikos G. Papadopoulos, Vasilis Papanikolaou, Alberto Papi, Bojidar Paralchev, Giannis Paraskevopoulos, Hae-Sim Park, Giovanni Passalacqua, Vincenzo Patella, Ian Pavord, Ruby Pawankar, Soren Pedersen, Susete Peleve, Simona Pellegino, Ana Pereira, Mariana Pereira, Tamara Perez, Andrea Perna, Diego Peroni, Oliver Pfaar, Nhan Pham-Thi, Bernard Pigearias, Isabelle Pin, Konstantina Piskou, Constantinos Pitsios, Davor Plavec, Dagmar Poethig, Wolfgang Pohl, Antonija Poplas Susic, Todor A. Popov, Fabienne Portejoie, Paul Potter, Lars Poulsen, Alexandra Prados-Torres, Fotis Prarros, David Price, Emmanuel Prokopakis, Francesca Puggioni, Elisa Puig-Domenech, Robert Puy, Klaus Rabe, Silvia Rabotti, Filip Raciborski, Josephine Ramos, Cristina Recalcati, Marysia T. Recto, Shereen M. Reda, Frederico S. Regateiro, Norbert Reider, Sietze Reitsma, Susana Repka-Ramirez, Erminia Ridolo, Janet Rimmer, Daniela Rivero Yeverino, Jose Angelo Rizzo, Carlos Robalo-Cordeiro, Graham Roberts, Karen Robles, Nicolas Roche, Monica Rodriguez Gonzalez, Erendira Rodriguez Zagal, Giovanni Rolla, Christine Rolland, Regina Roller-Wirnsberger, Miguel Roman Rodriguez, Antonino Romano, Jan Romantowski, Philippe Rombaux, Joel Romualdez, Jose Rosado-Pinto, Nelson Rosario, Lanny Rosenwasser, Oliviero Rossi, Menachem Rottem, Philip W. Rouadi, Nikoleta Rovina, Irma Rozman Sinur, Mauricio Ruiz, Lucy Tania Ruiz Segura, Dermot Ryan, Hironori Sagara, Daiki Sakai, Daiju Sakurai, Wafaa Saleh, Johanna Salimaki, Konstantinos Samitas, Boleslaw Samolinski, Maria Guadalupe Sanchez Coronel, Mario Sanchez-Borges, Jaime Sanchez-Lopez, Melissa Sansonna, Codrut Sarafoleanu, Faradiba Sarquis Serpa, Joaquin Sastre, Eleonora Savi, Agne Savonyte, Bisher Sawaf, Glenis K. Scadding, Sophie Scheire, Peter Schmid-Grendelmeier, Juan Francisco Schuhl, Holger Schunemann, Maria Schvalbova, Jorgen Schwarze, Nicola Scichilone, Gianenrico Senna, Cecilia Sepulveda, Elie Serrano, Sara Shamai, Aziz Sheikh, Mike Shields, Vasil Shishkov, Nikos Siafakas, Alexander Simeonov, Estelle F. E. R. Simons, Juan Carlos Sisul, Brigita Sitkauskiene, Ingelbjorg Skrindo, Tanja Soklic Kosak, Dirceu Sole, Martin Sondermann, Talant Sooronbaev, Manuel Soto-Martinez, Manuel Soto-Quiros, Barnaro Sousa Pinto, Milan Sova, Michael Soyka, Krzysztof Specjalski, Annette Sperl, Otto Spranger, Sofia Stamataki, Lina Stefanaki, Cristiana Stellato, Rafael Stelmach, Timo Strandberg, Petra Stute, Abirami Subramaniam, Charlotte Suppli Ulrik, Michael Sutherland, Silvia Sylvestre, Aikaterini Syrigou, Luis Taborda Barata, Nadejda Takovska, Rachel Tan, Frances Tan, Vincent Tan, Ing Ping Tang, Masami Taniguchi, Line Tannert, Pongsakorn Tantilipikorn, Jessica Tattersall, Filippo Tesi, Uta Thieme, Carel Thijs, Mike Thomas, Teresa To, Ana Maria Todo-Bom, Alkis Togias, Peter-Valentin Tomazic, Vesna Tomic-Spiric, Sanna Toppila-Salmi, Maria-Jose Torres Jaen, Elina Toskala, Massimo Triggiani, Nadja Triller, Katja Triller, Ioanna Tsiligianni, M. Uberti, Ruxandra Ulmeanu, Jure Urbancic, Marilyn Urrutia Pereira, Martina Vachova, Felipe Valdes, Rudolf Valenta, Marylin Valentin Rostan, Antonio Valero, Arunas Valiulis, Mina Vallianatou, Erkka Valovirta, Michiel Van Eerd, Eric Van Ganse, Marianne van Hage, Olivier Vandenplas, Tuula Vasankari, Dafina Vassileva, Cesar Velasco Munoz, Maria Teresa Ventura, Cecilia Vera-Munoz, Frederic Viart, Dilyana Vicheva, Pakit Vichyanond, Petra Vidgren, Giovanni Viegi, Claus Vogelmeier, Leena Von Hertzen, Theodoros Vontetsianos, Dimitris Vourdas, Vu Tran Thien Quan, Martin Wagenmann, Samantha Walker, Dana Wallace, Yun De Wang, Susan Waserman, Katrin Wehner, Magnus Wickman, Sian Williams, Dennis Williams, Nicola Wilson, Gary Wong, Kent Woo, Lucyna Wozniak, John Wright, Piotr Wroczynski, Paraskevi Xepapadaki, Plamen Yakovliev, Masao Yamaguchi, Kwok Yan, Yoke Yeow Yap, Mais Yassin, Barbara Yawn, Panayiotis Yiallouros, Arzu Yorgancioglu, Shigemi Yoshihara, Ian Young, Osman B. Yusuf, Asghar Zaidi, Fares Zaitoun, Petra Zalud, Heather Zar, M. T. Zedda, Mario E. Zernotti, Luo Zhang, Nanshan Zhong, Mihaela Zidarn, Torsten Zuberbier, and Celia Zubrinich. 2020. “Nrf2-Interacting Nutrients and COVID-19 : Time for Research to Develop Adaptation Strategies.” CLINICAL AND TRANSLATIONAL ALLERGY 10 (1). doi:10.1186/s13601-020-00362-7.
Vancouver
1.
Bousquet J, Cristol J-P, Czarlewski W, Anto JM, Martineau A, Haahtela T, et al. Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies. CLINICAL AND TRANSLATIONAL ALLERGY. 2020;10(1).
IEEE
[1]
J. Bousquet et al., “Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies,” CLINICAL AND TRANSLATIONAL ALLERGY, vol. 10, no. 1, 2020.
@article{8690178,
  abstract     = {There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.},
  articleno    = {58},
  author       = {Bousquet, Jean and Cristol, Jean-Paul and Czarlewski, Wienczyslawa and Anto, Josep M. and Martineau, Adrian and Haahtela, Tari and Fonseca, Susana C. and Iaccarino, Guido and Blain, Hubert and Fiocchi, Alessandro and Canonica, G. Walter and Fonseca, Joao A. and Vidal, Alain and Choi, Hak-Jong and Kim, Hyun Ju and Le Moing, Vincent and Reynes, Jacques and Sheikh, Aziz and Akdis, Cezmi A. and Zuberbier, Torsten and Abdul Latiff, Amir Hamzah and Abdullah, Baharudin and Aberer, Werner and Abusada, Nancy and Adcock, Ian and Afani, Alejandro and Agache, Ioana and Aggelidis, Xenofon and Agustin, Jenifer and Akdis, Cezmi A. and Akdis, Mubeccel and Al-Ahmad, Mona and Al-Zahab Bassam, Abou and Alburdan, Hussam and Aldrey-Palacios, Oscar and Alvarez Cuesta, Emilio and Alwan Salman, Hiba and Alzaabi, Ashraf and Amade, Salma and Ambrocio, Gene and Angles, Rosana and Annesi-Maesano, Isabella and Ansotegui, Ignacio J. and Anto, Josep M. and Ara Bardajo, Paula and Arasi, Stefania and Arrais, Margarete and Arshad, Hasan and Artesani, Maria-Cristina and Asayag, Estrella and Avolio, Francesca and Azhari, Khuzama and Bachert, Claus and Bagnasco, Diego and Baiardini, Ilaria and Bajrovic, Nissera and Bakakos, Petros and Bakeyala Mongono, Sergio and Balotro-Torres, Christine and Barba, Sergio and Barbara, Cristina and Barbosa, Elsa and Barreto, Bruno and Bartra, Joan and Basagana, Xavier and Bateman, Eric D. and Battur, Lkhagvaa and Bedbrook, Anna and Bedolla Barajas, Martin and Beghe, Bianca and Bekere, Antra and Bel, Elizabeth and Ben Kheder, Ali and Benson, Mikael and Berghea, Elena-Camelia and Bergmann, Karl-Christian and Bernardini, Roberto and Bernstein, David and Bewick, Mike and Bialek, Slawomir and Bialoszewski, Artur and Bieber, Thomas and Billo, Nils E. and Bilo, Maria-Beatrice and Bindslev-Jensen, Carsten and Bjermer, Leif and Blain, Hubert and Bobolea, Irina and Bochenska Marciniak, Malgorzata and Bond, Christine and Boner, Attilio and Bonini, Matteo and Bonini, Sergio and Bosnic-Anticevich, Sinthia and Bosse, Isabelle and Botskariova, Sofia and Bouchard, Jacques and Boulet, Louis-Philippe and Bourret, Rodolphe and Bousquet, Philippe and Braido, Fulvio and Briggs, Andrew and Brightling, Christopher E. and Brozek, Jan and Brussino, Luisa and Buhl, Roland and Bumbacea, Roxana and Buquicchio, Rosalva and Burguete Cabanas, Maria-Teresa and Bush, Andrew and Busse, William W. and Buters, Jeroen and Caballero-Fonseca, Fernan and Calderon, Moises A. and Calvo, Mario and Camargos, Paulo and Camuzat, Thierry and Canevari, F. R. and Cano, Antonio and Canonica, G. Walter and Capriles-Hulett, Arnaldo and Caraballo, Luis and Cardona, Vicky and Carlsen, Kai-Hakon and Carmona Pirez, Jonas and Caro, Jorge and Carr, Warner and Carreiro-Martins, Pedro and Carreon-Asuncion, Fredelita and Carriazo, Ana-Maria and Carrion y Ribas, Carme and Casale, Thomas and Castor, Mary-Ann and Castro, Elizabeth and Caviglia, A. 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P. and Pali-Scholl, Isabella and Palkonen, Susanna and Palmer, Stephen and Panaitescu Bunu, Carmen and Panzner, Petr and Papadopoulos, Nikos G. and Papanikolaou, Vasilis and Papi, Alberto and Paralchev, Bojidar and Paraskevopoulos, Giannis and Park, Hae-Sim and Passalacqua, Giovanni and Patella, Vincenzo and Pavord, Ian and Pawankar, Ruby and Pedersen, Soren and Peleve, Susete and Pellegino, Simona and Pereira, Ana and Pereira, Mariana and Perez, Tamara and Perna, Andrea and Peroni, Diego and Pfaar, Oliver and Pham-Thi, Nhan and Pigearias, Bernard and Pin, Isabelle and Piskou, Konstantina and Pitsios, Constantinos and Plavec, Davor and Poethig, Dagmar and Pohl, Wolfgang and Poplas Susic, Antonija and Popov, Todor A. and Portejoie, Fabienne and Potter, Paul and Poulsen, Lars and Prados-Torres, Alexandra and Prarros, Fotis and Price, David and Prokopakis, Emmanuel and Puggioni, Francesca and Puig-Domenech, Elisa and Puy, Robert and Rabe, Klaus and Rabotti, Silvia and Raciborski, Filip and Ramos, Josephine and Recalcati, Cristina and Recto, Marysia T. and Reda, Shereen M. and Regateiro, Frederico S. and Reider, Norbert and Reitsma, Sietze and Repka-Ramirez, Susana and Ridolo, Erminia and Rimmer, Janet and Rivero Yeverino, Daniela and Rizzo, Jose Angelo and Robalo-Cordeiro, Carlos and Roberts, Graham and Robles, Karen and Roche, Nicolas and Rodriguez Gonzalez, Monica and Rodriguez Zagal, Erendira and Rolla, Giovanni and Rolland, Christine and Roller-Wirnsberger, Regina and Roman Rodriguez, Miguel and Romano, Antonino and Romantowski, Jan and Rombaux, Philippe and Romualdez, Joel and Rosado-Pinto, Jose and Rosario, Nelson and Rosenwasser, Lanny and Rossi, Oliviero and Rottem, Menachem and Rouadi, Philip W. and Rovina, Nikoleta and Rozman Sinur, Irma and Ruiz, Mauricio and Ruiz Segura, Lucy Tania and Ryan, Dermot and Sagara, Hironori and Sakai, Daiki and Sakurai, Daiju and Saleh, Wafaa and Salimaki, Johanna and Samitas, Konstantinos and Samolinski, Boleslaw and Sanchez Coronel, Maria Guadalupe and Sanchez-Borges, Mario and Sanchez-Lopez, Jaime and Sansonna, Melissa and Sarafoleanu, Codrut and Sarquis Serpa, Faradiba and Sastre, Joaquin and Savi, Eleonora and Savonyte, Agne and Sawaf, Bisher and Scadding, Glenis K. and Scheire, Sophie and Schmid-Grendelmeier, Peter and Schuhl, Juan Francisco and Schunemann, Holger and Schvalbova, Maria and Schwarze, Jorgen and Scichilone, Nicola and Senna, Gianenrico and Sepulveda, Cecilia and Serrano, Elie and Shamai, Sara and Sheikh, Aziz and Shields, Mike and Shishkov, Vasil and Siafakas, Nikos and Simeonov, Alexander and Simons, Estelle F. E. R. and Sisul, Juan Carlos and Sitkauskiene, Brigita and Skrindo, Ingelbjorg and Soklic Kosak, Tanja and Sole, Dirceu and Sondermann, Martin and Sooronbaev, Talant and Soto-Martinez, Manuel and Soto-Quiros, Manuel and Pinto, Barnaro Sousa and Sova, Milan and Soyka, Michael and Specjalski, Krzysztof and Sperl, Annette and Spranger, Otto and Stamataki, Sofia and Stefanaki, Lina and Stellato, Cristiana and Stelmach, Rafael and Strandberg, Timo and Stute, Petra and Subramaniam, Abirami and Suppli Ulrik, Charlotte and Sutherland, Michael and Sylvestre, Silvia and Syrigou, Aikaterini and Taborda Barata, Luis and Takovska, Nadejda and Tan, Rachel and Tan, Frances and Tan, Vincent and Tang, Ing Ping and Taniguchi, Masami and Tannert, Line and Tantilipikorn, Pongsakorn and Tattersall, Jessica and Tesi, Filippo and Thieme, Uta and Thijs, Carel and Thomas, Mike and To, Teresa and Todo-Bom, Ana Maria and Togias, Alkis and Tomazic, Peter-Valentin and Tomic-Spiric, Vesna and Toppila-Salmi, Sanna and Torres Jaen, Maria-Jose and Toskala, Elina and Triggiani, Massimo and Triller, Nadja and Triller, Katja and Tsiligianni, Ioanna and Uberti, M. and Ulmeanu, Ruxandra and Urbancic, Jure and Urrutia Pereira, Marilyn and Vachova, Martina and Valdes, Felipe and Valenta, Rudolf and Valentin Rostan, Marylin and Valero, Antonio and Valiulis, Arunas and Vallianatou, Mina and Valovirta, Erkka and Van Eerd, Michiel and Van Ganse, Eric and van Hage, Marianne and Vandenplas, Olivier and Vasankari, Tuula and Vassileva, Dafina and Velasco Munoz, Cesar and Ventura, Maria Teresa and Vera-Munoz, Cecilia and Viart, Frederic and Vicheva, Dilyana and Vichyanond, Pakit and Vidgren, Petra and Viegi, Giovanni and Vogelmeier, Claus and Von Hertzen, Leena and Vontetsianos, Theodoros and Vourdas, Dimitris and Tran Thien Quan, Vu and Wagenmann, Martin and Walker, Samantha and Wallace, Dana and De Wang, Yun and Waserman, Susan and Wehner, Katrin and Wickman, Magnus and Williams, Sian and Williams, Dennis and Wilson, Nicola and Wong, Gary and Woo, Kent and Wozniak, Lucyna and Wright, John and Wroczynski, Piotr and Xepapadaki, Paraskevi and Yakovliev, Plamen and Yamaguchi, Masao and Yan, Kwok and Yap, Yoke Yeow and Yassin, Mais and Yawn, Barbara and Yiallouros, Panayiotis and Yorgancioglu, Arzu and Yoshihara, Shigemi and Young, Ian and Yusuf, Osman B. and Zaidi, Asghar and Zaitoun, Fares and Zalud, Petra and Zar, Heather and Zedda, M. T. and Zernotti, Mario E. and Zhang, Luo and Zhong, Nanshan and Zidarn, Mihaela and Zuberbier, Torsten and Zubrinich, Celia},
  issn         = {2045-7022},
  journal      = {CLINICAL AND TRANSLATIONAL ALLERGY},
  keywords     = {ENDOPLASMIC-RETICULUM STRESS,NF-KAPPA-B,ACUTE LUNG INJURY,RESPIRATORY,SYNDROME CORONAVIRUS,MUSCLE-CELL PROLIFERATION,OXIDATIVE STRESS,INSULIN-RESISTANCE,SIGNALING PATHWAY,NRF2 ACTIVATORS,SULFORAPHANE,PROTECTS,COVID-19,Nrf2,Foods,Nutrients,Insulin resistance,Obesity,TRPA1},
  language     = {eng},
  number       = {1},
  pages        = {18},
  title        = {Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies},
  url          = {http://dx.doi.org/10.1186/s13601-020-00362-7},
  volume       = {10},
  year         = {2020},
}

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