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Vaginal microbiota and human papillomavirus infection among young Swedish women

Liqin Cheng, Johanna Norenhag, Yue O. O. Hu, Nele Brusselaers (UGent) , Emma Fransson, Andreas Ahrlund-Richter, Unnur Gudnadottir, Pia Angelidou, Yinghua Zha, Marica Hamsten, et al.
(2020) NPJ BIOFILMS AND MICROBIOMES. 6(1).
Author
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Abstract
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.
Keywords
PREVALENCE, STOCKHOLM, CANCER, COMMUNITIES, DIVERSITY, YOUTH, DNA

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MLA
Cheng, Liqin, et al. “Vaginal Microbiota and Human Papillomavirus Infection among Young Swedish Women.” NPJ BIOFILMS AND MICROBIOMES, vol. 6, no. 1, 2020, doi:10.1038/s41522-020-00146-8.
APA
Cheng, L., Norenhag, J., Hu, Y. O. O., Brusselaers, N., Fransson, E., Ahrlund-Richter, A., … Du, J. (2020). Vaginal microbiota and human papillomavirus infection among young Swedish women. NPJ BIOFILMS AND MICROBIOMES, 6(1). https://doi.org/10.1038/s41522-020-00146-8
Chicago author-date
Cheng, Liqin, Johanna Norenhag, Yue O. O. Hu, Nele Brusselaers, Emma Fransson, Andreas Ahrlund-Richter, Unnur Gudnadottir, et al. 2020. “Vaginal Microbiota and Human Papillomavirus Infection among Young Swedish Women.” NPJ BIOFILMS AND MICROBIOMES 6 (1). https://doi.org/10.1038/s41522-020-00146-8.
Chicago author-date (all authors)
Cheng, Liqin, Johanna Norenhag, Yue O. O. Hu, Nele Brusselaers, Emma Fransson, Andreas Ahrlund-Richter, Unnur Gudnadottir, Pia Angelidou, Yinghua Zha, Marica Hamsten, Ina Schuppe-Koistinen, Matts Olovsson, Lars Engstrand, and Juan Du. 2020. “Vaginal Microbiota and Human Papillomavirus Infection among Young Swedish Women.” NPJ BIOFILMS AND MICROBIOMES 6 (1). doi:10.1038/s41522-020-00146-8.
Vancouver
1.
Cheng L, Norenhag J, Hu YOO, Brusselaers N, Fransson E, Ahrlund-Richter A, et al. Vaginal microbiota and human papillomavirus infection among young Swedish women. NPJ BIOFILMS AND MICROBIOMES. 2020;6(1).
IEEE
[1]
L. Cheng et al., “Vaginal microbiota and human papillomavirus infection among young Swedish women,” NPJ BIOFILMS AND MICROBIOMES, vol. 6, no. 1, 2020.
@article{8688793,
  abstract     = {{Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.}},
  articleno    = {{39}},
  author       = {{Cheng, Liqin and Norenhag, Johanna and Hu, Yue O. O. and Brusselaers, Nele and Fransson, Emma and Ahrlund-Richter, Andreas and Gudnadottir, Unnur and Angelidou, Pia and Zha, Yinghua and Hamsten, Marica and Schuppe-Koistinen, Ina and Olovsson, Matts and Engstrand, Lars and Du, Juan}},
  issn         = {{2055-5008}},
  journal      = {{NPJ BIOFILMS AND MICROBIOMES}},
  keywords     = {{PREVALENCE,STOCKHOLM,CANCER,COMMUNITIES,DIVERSITY,YOUTH,DNA}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{10}},
  title        = {{Vaginal microbiota and human papillomavirus infection among young Swedish women}},
  url          = {{http://doi.org/10.1038/s41522-020-00146-8}},
  volume       = {{6}},
  year         = {{2020}},
}
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