Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host's innate immunity
- Author
- Matthias Dierick (UGent) , Daisy Vanrompay (UGent) , Bert Devriendt (UGent) and Eric Cox (UGent)
- Organization
- Abstract
- Lactoferrin is a multi-functional protein found in the secretions of mammals. The antimicrobial activity of lactoferrin was the first to be discovered and was assumed to be solely dependent on its iron-chelating ability. However, lactoferrin has been reported to display proteolytic activity towards bacterial virulence factors and to modulate the host defence by stimulating the immune system and balancing pathogen-induced inflammation. Here, we review the current understandings of the antimicrobial effect, interaction with host cells, and innate immune modulation of lactoferrin, and put forward this moonlighting protein as a possible alternative for antibiotics.
- Keywords
- lactoferrin, antimicrobial, proteolytic activity, immunomodulation, RECOMBINANT HUMAN LACTOFERRIN, COLISTIN-RESISTANCE GENE, HUMAN-MILK LACTOFERRIN, BOVINE LACTOFERRIN, ESCHERICHIA-COLI, PROTEOLYTIC ACTIVITY, DELTA-LACTOFERRIN, PROTEIN, BINDING, EXPRESSION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8688544
- MLA
- Dierick, Matthias, et al. “Lactoferrin, a Versatile Natural Antimicrobial Glycoprotein That Modulates the Host’s Innate Immunity.” BIOCHEMISTRY AND CELL BIOLOGY, vol. 99, no. 1, 2021, pp. 61–65, doi:10.1139/bcb-2020-0080.
- APA
- Dierick, M., Vanrompay, D., Devriendt, B., & Cox, E. (2021). Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host’s innate immunity. BIOCHEMISTRY AND CELL BIOLOGY, 99(1), 61–65. https://doi.org/10.1139/bcb-2020-0080
- Chicago author-date
- Dierick, Matthias, Daisy Vanrompay, Bert Devriendt, and Eric Cox. 2021. “Lactoferrin, a Versatile Natural Antimicrobial Glycoprotein That Modulates the Host’s Innate Immunity.” BIOCHEMISTRY AND CELL BIOLOGY 99 (1): 61–65. https://doi.org/10.1139/bcb-2020-0080.
- Chicago author-date (all authors)
- Dierick, Matthias, Daisy Vanrompay, Bert Devriendt, and Eric Cox. 2021. “Lactoferrin, a Versatile Natural Antimicrobial Glycoprotein That Modulates the Host’s Innate Immunity.” BIOCHEMISTRY AND CELL BIOLOGY 99 (1): 61–65. doi:10.1139/bcb-2020-0080.
- Vancouver
- 1.Dierick M, Vanrompay D, Devriendt B, Cox E. Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host’s innate immunity. BIOCHEMISTRY AND CELL BIOLOGY. 2021;99(1):61–5.
- IEEE
- [1]M. Dierick, D. Vanrompay, B. Devriendt, and E. Cox, “Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host’s innate immunity,” BIOCHEMISTRY AND CELL BIOLOGY, vol. 99, no. 1, pp. 61–65, 2021.
@article{8688544,
abstract = {{Lactoferrin is a multi-functional protein found in the secretions of mammals. The antimicrobial activity of lactoferrin was the first to be discovered and was assumed to be solely dependent on its iron-chelating ability. However, lactoferrin has been reported to display proteolytic activity towards bacterial virulence factors and to modulate the host defence by stimulating the immune system and balancing pathogen-induced inflammation. Here, we review the current understandings of the antimicrobial effect, interaction with host cells, and innate immune modulation of lactoferrin, and put forward this moonlighting protein as a possible alternative for antibiotics.}},
author = {{Dierick, Matthias and Vanrompay, Daisy and Devriendt, Bert and Cox, Eric}},
issn = {{0829-8211}},
journal = {{BIOCHEMISTRY AND CELL BIOLOGY}},
keywords = {{lactoferrin,antimicrobial,proteolytic activity,immunomodulation,RECOMBINANT HUMAN LACTOFERRIN,COLISTIN-RESISTANCE GENE,HUMAN-MILK LACTOFERRIN,BOVINE LACTOFERRIN,ESCHERICHIA-COLI,PROTEOLYTIC ACTIVITY,DELTA-LACTOFERRIN,PROTEIN,BINDING,EXPRESSION}},
language = {{eng}},
location = {{Lima, Peru}},
number = {{1}},
pages = {{61--65}},
title = {{Lactoferrin, a versatile natural antimicrobial glycoprotein that modulates the host's innate immunity}},
url = {{http://doi.org/10.1139/bcb-2020-0080}},
volume = {{99}},
year = {{2021}},
}
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