
Congenital CMV-associated hearing loss : can brain imaging predict hearing outcome?
- Author
- Laura Craeghs, JULIE GODERIS (UGent) , Frederic Acke (UGent) , Annelies Keymeulen (UGent) , Koenraad Smets (UGent) , Helen Van Hoecke (UGent) , Els De Leenheer (UGent) , An Boudewyns, Christian Desloovere, Rudolf Kuhweide, Marie Muylle, Liesbeth Royackers, Isabelle Schatteman and Ingeborg Dhooge (UGent)
- Organization
- Abstract
- Objectives: Congenital cytomegalovirus (cCMV) infection is the leading cause of nonhereditary sensorineural hearing loss in childhood and is also associated with CNS abnormalities. The main objective is to investigate the prognostic value of neonatal cranial ultrasound (cUS) and cranial magnetic resonance imaging (cMRI) in predicting long-term hearing outcome in a large cohort of cCMV-infected symptomatic and asymptomatic patients. Design: Data were prospectively collected from a multicentre Flemish registry of children with cCMV infection born between 2007 and 2016. Neonatal cUS and cMRI scans were examined for lesions related to cCMV infection. Audiometric results at different time points were analyzed. The imaging and audiometric results were linked and diagnostic values of cUS and cMRI were calculated for the different hearing outcomes. Results: We were able to include 411 cCMV patients, of whom 40% was considered symptomatic at birth. Cranial ultrasound abnormalities associated with cCMV infection were found in 76 children (22.2% of the cUS scans), whereas cMRI revealed abnormalities in 74 patients (26.9% of the cMRI scans). A significant relation could be found between the presence of cUS or cMRI abnormalities and hearing loss at baseline and last follow-up. Cranial ultrasound and cMRI findings were not significantly correlated with the development of delayed-onset hearing loss. Specificity and sensitivity of an abnormal cUS to predict hearing loss at final follow-up were 84% and 43%, respectively compared with 78% and 39% for cMRI. Normal cUS and cMRI findings have a negative predictive value of 91% and 92%, respectively, for the development of delayed-onset hearing loss. Conclusions: Neuroimaging evidence of CNS involvement in the neonatal period is associated with the presence of hearing loss in children with a cCMV infection. Imaging abnormalities are not predictive for the development of delayed-onset hearing loss.
- Keywords
- Speech and Hearing, Otorhinolaryngology, Brain imaging, Congenital cytomegalovirus infection, Hearing loss, Magnetic resonance imaging, Ultrasound
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8688302
- MLA
- Craeghs, Laura, et al. “Congenital CMV-Associated Hearing Loss : Can Brain Imaging Predict Hearing Outcome?” EAR AND HEARING, vol. 42, no. 2, 2021, pp. 373–80, doi:10.1097/aud.0000000000000927.
- APA
- Craeghs, L., GODERIS, J., Acke, F., Keymeulen, A., Smets, K., Van Hoecke, H., … Dhooge, I. (2021). Congenital CMV-associated hearing loss : can brain imaging predict hearing outcome? EAR AND HEARING, 42(2), 373–380. https://doi.org/10.1097/aud.0000000000000927
- Chicago author-date
- Craeghs, Laura, JULIE GODERIS, Frederic Acke, Annelies Keymeulen, Koenraad Smets, Helen Van Hoecke, Els De Leenheer, et al. 2021. “Congenital CMV-Associated Hearing Loss : Can Brain Imaging Predict Hearing Outcome?” EAR AND HEARING 42 (2): 373–80. https://doi.org/10.1097/aud.0000000000000927.
- Chicago author-date (all authors)
- Craeghs, Laura, JULIE GODERIS, Frederic Acke, Annelies Keymeulen, Koenraad Smets, Helen Van Hoecke, Els De Leenheer, An Boudewyns, Christian Desloovere, Rudolf Kuhweide, Marie Muylle, Liesbeth Royackers, Isabelle Schatteman, and Ingeborg Dhooge. 2021. “Congenital CMV-Associated Hearing Loss : Can Brain Imaging Predict Hearing Outcome?” EAR AND HEARING 42 (2): 373–380. doi:10.1097/aud.0000000000000927.
- Vancouver
- 1.Craeghs L, GODERIS J, Acke F, Keymeulen A, Smets K, Van Hoecke H, et al. Congenital CMV-associated hearing loss : can brain imaging predict hearing outcome? EAR AND HEARING. 2021;42(2):373–80.
- IEEE
- [1]L. Craeghs et al., “Congenital CMV-associated hearing loss : can brain imaging predict hearing outcome?,” EAR AND HEARING, vol. 42, no. 2, pp. 373–380, 2021.
@article{8688302, abstract = {{Objectives: Congenital cytomegalovirus (cCMV) infection is the leading cause of nonhereditary sensorineural hearing loss in childhood and is also associated with CNS abnormalities. The main objective is to investigate the prognostic value of neonatal cranial ultrasound (cUS) and cranial magnetic resonance imaging (cMRI) in predicting long-term hearing outcome in a large cohort of cCMV-infected symptomatic and asymptomatic patients. Design: Data were prospectively collected from a multicentre Flemish registry of children with cCMV infection born between 2007 and 2016. Neonatal cUS and cMRI scans were examined for lesions related to cCMV infection. Audiometric results at different time points were analyzed. The imaging and audiometric results were linked and diagnostic values of cUS and cMRI were calculated for the different hearing outcomes. Results: We were able to include 411 cCMV patients, of whom 40% was considered symptomatic at birth. Cranial ultrasound abnormalities associated with cCMV infection were found in 76 children (22.2% of the cUS scans), whereas cMRI revealed abnormalities in 74 patients (26.9% of the cMRI scans). A significant relation could be found between the presence of cUS or cMRI abnormalities and hearing loss at baseline and last follow-up. Cranial ultrasound and cMRI findings were not significantly correlated with the development of delayed-onset hearing loss. Specificity and sensitivity of an abnormal cUS to predict hearing loss at final follow-up were 84% and 43%, respectively compared with 78% and 39% for cMRI. Normal cUS and cMRI findings have a negative predictive value of 91% and 92%, respectively, for the development of delayed-onset hearing loss. Conclusions: Neuroimaging evidence of CNS involvement in the neonatal period is associated with the presence of hearing loss in children with a cCMV infection. Imaging abnormalities are not predictive for the development of delayed-onset hearing loss.}}, author = {{Craeghs, Laura and GODERIS, JULIE and Acke, Frederic and Keymeulen, Annelies and Smets, Koenraad and Van Hoecke, Helen and De Leenheer, Els and Boudewyns, An and Desloovere, Christian and Kuhweide, Rudolf and Muylle, Marie and Royackers, Liesbeth and Schatteman, Isabelle and Dhooge, Ingeborg}}, issn = {{0196-0202}}, journal = {{EAR AND HEARING}}, keywords = {{Speech and Hearing,Otorhinolaryngology,Brain imaging,Congenital cytomegalovirus infection,Hearing loss,Magnetic resonance imaging,Ultrasound}}, language = {{eng}}, number = {{2}}, pages = {{373--380}}, title = {{Congenital CMV-associated hearing loss : can brain imaging predict hearing outcome?}}, url = {{http://doi.org/10.1097/aud.0000000000000927}}, volume = {{42}}, year = {{2021}}, }
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