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Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer

(2021) ISCIENCE. 24(1).
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Abstract
M2-tumor-associated macrophages (M2-TAMs) in the tumor microenvironment represent a prognostic indicator for poor outcome in triple-negative breast cancer (TNBC). Here we show that Prune-1 overexpression in human TNBC patients has positive correlation to lung metastasis and infiltrating M2-TAMs. Thus, we demonstrate that Prune-1 promotes lung metastasis in a genetically engineered mouse model of metastatic TNBC augmenting M2-polarization of TAMs within the tumor microenvironment. Thus, this occurs through TGF-beta enhancement, IL-17F secretion, and extracellular vesicle protein content modulation. We also find murine inactivating gene variants in human TNBC patient cohorts that are involved in activation of the innate immune response, cell adhesion, apoptotic pathways, and DNA repair. Altogether, we indicate that the overexpression of Prune-1, IL-10, COL4A1, ILR1, and PDGFB, together with inactivating mutations of PDE9A, CD244, Sirpblb, SV140, lqcal, and PIP5K1B genes, might represent a route of metastatic lung dissemination that need future prognostic validations.
Keywords
NF-KAPPA-B, H-PRUNE, GENE-EXPRESSION, MESENCHYMAL TRANSITION, SIGNAL-TRANSDUCTION, CELL-MIGRATION, PROTEIN-KINASE, TGF-BETA, ACTIVATION, SURVIVAL

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MLA
Ferrucci, V., et al. “Prune-1 Drives Polarization of Tumor-Associated Macrophages (TAMs) within the Lung Metastatic Niche in Triple-Negative Breast Cancer.” ISCIENCE, vol. 24, no. 1, 2021, doi:10.1016/j.isci.2020.101938.
APA
Ferrucci, V., Asadzadeh, F., Collina, F., Siciliano, R., Boccia, A., Marrone, L., … Zollo, M. (2021). Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer. ISCIENCE, 24(1). https://doi.org/10.1016/j.isci.2020.101938
Chicago author-date
Ferrucci, V, F Asadzadeh, F Collina, R Siciliano, A Boccia, L Marrone, D Spano, et al. 2021. “Prune-1 Drives Polarization of Tumor-Associated Macrophages (TAMs) within the Lung Metastatic Niche in Triple-Negative Breast Cancer.” ISCIENCE 24 (1). https://doi.org/10.1016/j.isci.2020.101938.
Chicago author-date (all authors)
Ferrucci, V, F Asadzadeh, F Collina, R Siciliano, A Boccia, L Marrone, D Spano, M Carotenuto, CM Chiarolla, D De Martino, G De Vita, A Macrì, L Dassi, Jonathan Vandenbussche, N Marino, M Cantile, G Paolella, F D’Andrea, M di Bonito, Kris Gevaert, and M Zollo. 2021. “Prune-1 Drives Polarization of Tumor-Associated Macrophages (TAMs) within the Lung Metastatic Niche in Triple-Negative Breast Cancer.” ISCIENCE 24 (1). doi:10.1016/j.isci.2020.101938.
Vancouver
1.
Ferrucci V, Asadzadeh F, Collina F, Siciliano R, Boccia A, Marrone L, et al. Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer. ISCIENCE. 2021;24(1).
IEEE
[1]
V. Ferrucci et al., “Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer,” ISCIENCE, vol. 24, no. 1, 2021.
@article{8688148,
  abstract     = {{M2-tumor-associated macrophages (M2-TAMs) in the tumor microenvironment represent a prognostic indicator for poor outcome in triple-negative breast cancer (TNBC).

Here we show that Prune-1 overexpression in human TNBC patients has positive correlation to lung metastasis and infiltrating M2-TAMs. Thus, we demonstrate that Prune-1 promotes lung metastasis in a genetically engineered mouse model of metastatic TNBC augmenting M2-polarization of TAMs within the tumor microenvironment. Thus, this occurs through TGF-beta enhancement, IL-17F secretion, and extracellular vesicle protein content modulation.

We also find murine inactivating gene variants in human TNBC patient cohorts that are involved in activation of the innate immune response, cell adhesion, apoptotic pathways, and DNA repair. Altogether, we indicate that the overexpression of Prune-1, IL-10, COL4A1, ILR1, and PDGFB, together with inactivating mutations of PDE9A, CD244, Sirpblb, SV140, lqcal, and PIP5K1B genes, might represent a route of metastatic lung dissemination that need future prognostic validations.}},
  articleno    = {{101938}},
  author       = {{Ferrucci, V and Asadzadeh, F and Collina, F and Siciliano, R and Boccia, A and Marrone, L and Spano, D and Carotenuto, M and Chiarolla, CM and De Martino, D and De Vita, G and Macrì, A and Dassi, L and Vandenbussche, Jonathan and Marino, N and Cantile, M and Paolella, G and D'Andrea, F and di Bonito, M and Gevaert, Kris and Zollo, M}},
  issn         = {{2589-0042}},
  journal      = {{ISCIENCE}},
  keywords     = {{NF-KAPPA-B,H-PRUNE,GENE-EXPRESSION,MESENCHYMAL TRANSITION,SIGNAL-TRANSDUCTION,CELL-MIGRATION,PROTEIN-KINASE,TGF-BETA,ACTIVATION,SURVIVAL}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{44}},
  title        = {{Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer}},
  url          = {{http://dx.doi.org/10.1016/j.isci.2020.101938}},
  volume       = {{24}},
  year         = {{2021}},
}

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