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Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts

Sébastien Guillet (UGent) , Vladislav Voloshkin (UGent) , Marina Saab (UGent) , Marek Beliš (UGent) , Kristof Van Hecke (UGent) , Fady Nahra (UGent) and Steven Nolan (UGent)
(2020) CHEMICAL COMMUNICATIONS. 56(44). p.5953-5956
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Abstract
The reaction mechanism leading to the formation of cross-coupling palladium pre-catalysts of the PEPPSI family was investigated. Two intermediates were isolated and proved to be both suitable synthons to the pre-catalysts, with one permitting the design of a novel and greener user-friendly synthetic route. In light of this mechanistic understanding, the traditional one-pot method was shown to be possible using stoichiometric amounts of throw-away ligand, which represents a considerable synthetic improvement over the wasteful "in pyridine" approach.
Keywords
N-HETEROCYCLIC CARBENE, CROSS-COUPLING REACTION, COMPLEXES SYNTHESIS, ARYL HALIDES, AMINATION, PD-PEPPSI-IPENT(CL), PRECATALYST, IPENT

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MLA
Guillet, Sébastien, et al. “Understanding Existing and Designing Novel Synthetic Routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 Pre-Catalysts.” CHEMICAL COMMUNICATIONS, vol. 56, no. 44, Royal Soc Chemistry, 2020, pp. 5953–56, doi:10.1039/d0cc02262d.
APA
Guillet, S., Voloshkin, V., Saab, M., Beliš, M., Van Hecke, K., Nahra, F., & Nolan, S. (2020). Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts. CHEMICAL COMMUNICATIONS, 56(44), 5953–5956. https://doi.org/10.1039/d0cc02262d
Chicago author-date
Guillet, Sébastien, Vladislav Voloshkin, Marina Saab, Marek Beliš, Kristof Van Hecke, Fady Nahra, and Steven Nolan. 2020. “Understanding Existing and Designing Novel Synthetic Routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 Pre-Catalysts.” CHEMICAL COMMUNICATIONS 56 (44): 5953–56. https://doi.org/10.1039/d0cc02262d.
Chicago author-date (all authors)
Guillet, Sébastien, Vladislav Voloshkin, Marina Saab, Marek Beliš, Kristof Van Hecke, Fady Nahra, and Steven Nolan. 2020. “Understanding Existing and Designing Novel Synthetic Routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 Pre-Catalysts.” CHEMICAL COMMUNICATIONS 56 (44): 5953–5956. doi:10.1039/d0cc02262d.
Vancouver
1.
Guillet S, Voloshkin V, Saab M, Beliš M, Van Hecke K, Nahra F, et al. Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts. CHEMICAL COMMUNICATIONS. 2020;56(44):5953–6.
IEEE
[1]
S. Guillet et al., “Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts,” CHEMICAL COMMUNICATIONS, vol. 56, no. 44, pp. 5953–5956, 2020.
@article{8688115,
  abstract     = {{The reaction mechanism leading to the formation of cross-coupling palladium pre-catalysts of the PEPPSI family was investigated. Two intermediates were isolated and proved to be both suitable synthons to the pre-catalysts, with one permitting the design of a novel and greener user-friendly synthetic route. In light of this mechanistic understanding, the traditional one-pot method was shown to be possible using stoichiometric amounts of throw-away ligand, which represents a considerable synthetic improvement over the wasteful "in pyridine" approach.}},
  author       = {{Guillet, Sébastien and Voloshkin, Vladislav and Saab, Marina and Beliš, Marek and Van Hecke, Kristof and Nahra, Fady and Nolan, Steven}},
  issn         = {{1359-7345}},
  journal      = {{CHEMICAL COMMUNICATIONS}},
  keywords     = {{N-HETEROCYCLIC CARBENE,CROSS-COUPLING REACTION,COMPLEXES SYNTHESIS,ARYL HALIDES,AMINATION,PD-PEPPSI-IPENT(CL),PRECATALYST,IPENT}},
  language     = {{eng}},
  number       = {{44}},
  pages        = {{5953--5956}},
  publisher    = {{Royal Soc Chemistry}},
  title        = {{Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts}},
  url          = {{http://dx.doi.org/10.1039/d0cc02262d}},
  volume       = {{56}},
  year         = {{2020}},
}

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