Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts
- Author
- Sébastien Guillet (UGent) , Vladislav Voloshkin (UGent) , Marina Saab (UGent) , Marek Beliš (UGent) , Kristof Van Hecke (UGent) , Fady Nahra (UGent) and Steven Nolan (UGent)
- Organization
- Abstract
- The reaction mechanism leading to the formation of cross-coupling palladium pre-catalysts of the PEPPSI family was investigated. Two intermediates were isolated and proved to be both suitable synthons to the pre-catalysts, with one permitting the design of a novel and greener user-friendly synthetic route. In light of this mechanistic understanding, the traditional one-pot method was shown to be possible using stoichiometric amounts of throw-away ligand, which represents a considerable synthetic improvement over the wasteful "in pyridine" approach.
- Keywords
- N-HETEROCYCLIC CARBENE, CROSS-COUPLING REACTION, COMPLEXES SYNTHESIS, ARYL HALIDES, AMINATION, PD-PEPPSI-IPENT(CL), PRECATALYST, IPENT
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8688115
- MLA
- Guillet, Sébastien, et al. “Understanding Existing and Designing Novel Synthetic Routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 Pre-Catalysts.” CHEMICAL COMMUNICATIONS, vol. 56, no. 44, Royal Soc Chemistry, 2020, pp. 5953–56, doi:10.1039/d0cc02262d.
- APA
- Guillet, S., Voloshkin, V., Saab, M., Beliš, M., Van Hecke, K., Nahra, F., & Nolan, S. (2020). Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts. CHEMICAL COMMUNICATIONS, 56(44), 5953–5956. https://doi.org/10.1039/d0cc02262d
- Chicago author-date
- Guillet, Sébastien, Vladislav Voloshkin, Marina Saab, Marek Beliš, Kristof Van Hecke, Fady Nahra, and Steven Nolan. 2020. “Understanding Existing and Designing Novel Synthetic Routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 Pre-Catalysts.” CHEMICAL COMMUNICATIONS 56 (44): 5953–56. https://doi.org/10.1039/d0cc02262d.
- Chicago author-date (all authors)
- Guillet, Sébastien, Vladislav Voloshkin, Marina Saab, Marek Beliš, Kristof Van Hecke, Fady Nahra, and Steven Nolan. 2020. “Understanding Existing and Designing Novel Synthetic Routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 Pre-Catalysts.” CHEMICAL COMMUNICATIONS 56 (44): 5953–5956. doi:10.1039/d0cc02262d.
- Vancouver
- 1.Guillet S, Voloshkin V, Saab M, Beliš M, Van Hecke K, Nahra F, et al. Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts. CHEMICAL COMMUNICATIONS. 2020;56(44):5953–6.
- IEEE
- [1]S. Guillet et al., “Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts,” CHEMICAL COMMUNICATIONS, vol. 56, no. 44, pp. 5953–5956, 2020.
@article{8688115,
abstract = {The reaction mechanism leading to the formation of cross-coupling palladium pre-catalysts of the PEPPSI family was investigated. Two intermediates were isolated and proved to be both suitable synthons to the pre-catalysts, with one permitting the design of a novel and greener user-friendly synthetic route. In light of this mechanistic understanding, the traditional one-pot method was shown to be possible using stoichiometric amounts of throw-away ligand, which represents a considerable synthetic improvement over the wasteful "in pyridine" approach.},
author = {Guillet, Sébastien and Voloshkin, Vladislav and Saab, Marina and Beliš, Marek and Van Hecke, Kristof and Nahra, Fady and Nolan, Steven},
issn = {1359-7345},
journal = {CHEMICAL COMMUNICATIONS},
keywords = {N-HETEROCYCLIC CARBENE,CROSS-COUPLING REACTION,COMPLEXES SYNTHESIS,ARYL HALIDES,AMINATION,PD-PEPPSI-IPENT(CL),PRECATALYST,IPENT},
language = {eng},
number = {44},
pages = {5953--5956},
publisher = {Royal Soc Chemistry},
title = {Understanding existing and designing novel synthetic routes to Pd-PEPPSI-NHC and Pd-PEPPSI-PR3 pre-catalysts},
url = {http://dx.doi.org/10.1039/d0cc02262d},
volume = {56},
year = {2020},
}
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