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Influence of multiple animal scanning on image quality for the Sedecal SuperArgus2R preclinical PET scanner

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Abstract
Background: Increased throughput in small animal preclinical studies using positron emission tomography leads to reduced costs and improved efficiency of experimental design, however the presence of multiple off-centre subjects, as opposed to a single centered one, may affect image quality in several ways. Methods: We evaluated the count rate performance using a NEMA scatter phantom. A Monte Carlo simulation of the system was validated against this dataset and used to simulate the count rate performance for dual scatter phantoms. NEMA NU4 image quality phantoms were then scanned in the central and offset positions, as well as in the offset position next to a uniform activity phantom. Uniformity, recovery coefficients and spillover ratios were then compared, as were two time frames for acquisition. Results: Count rate performance assessed with a single NEMA scatter phantom was in line with previous literature, with simulated data in good agreement. Simulation of dual scatter phantoms showed an increase in scatter fraction. For the NEMA Image Quality phantom, uniformity and Recovery coefficients were degraded in the offset, and dual phantom cases, while spillover ratios were increased, notably when the chamber was placed nearest the gantry. Image quality metrics were comparable between the 20- and 10 min timeframes. Conclusion: Dual animal scanning results in some loss of image quality on the Sedecal Argus PET scanner; however, this degradation is within acceptable limits.
Keywords
preclinical PET CT, dual phantom scanning, multiple animal scanning, Monte Carlo simulation, image quality, NEMA NU4, Sedecal Argus 2R, MICE, VALIDATION, SIMULATION

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MLA
Efthimiou, Nikos, et al. “Influence of Multiple Animal Scanning on Image Quality for the Sedecal SuperArgus2R Preclinical PET Scanner.” FRONTIERS IN PHYSICS, vol. 8, 2021, doi:10.3389/fphy.2020.531662.
APA
Efthimiou, N., Wright, J. D., Clayton, L., Renard, I., Zagni, F., De Vasconcelos Caribé, P. R. R., … Cawthorne, C. J. (2021). Influence of multiple animal scanning on image quality for the Sedecal SuperArgus2R preclinical PET scanner. FRONTIERS IN PHYSICS, 8. https://doi.org/10.3389/fphy.2020.531662
Chicago author-date
Efthimiou, Nikos, John D. Wright, Luke Clayton, Isaline Renard, Federico Zagni, Paulo Rauli Rafeson De Vasconcelos Caribé, Stephen J. Archibald, and Christopher J. Cawthorne. 2021. “Influence of Multiple Animal Scanning on Image Quality for the Sedecal SuperArgus2R Preclinical PET Scanner.” FRONTIERS IN PHYSICS 8. https://doi.org/10.3389/fphy.2020.531662.
Chicago author-date (all authors)
Efthimiou, Nikos, John D. Wright, Luke Clayton, Isaline Renard, Federico Zagni, Paulo Rauli Rafeson De Vasconcelos Caribé, Stephen J. Archibald, and Christopher J. Cawthorne. 2021. “Influence of Multiple Animal Scanning on Image Quality for the Sedecal SuperArgus2R Preclinical PET Scanner.” FRONTIERS IN PHYSICS 8. doi:10.3389/fphy.2020.531662.
Vancouver
1.
Efthimiou N, Wright JD, Clayton L, Renard I, Zagni F, De Vasconcelos Caribé PRR, et al. Influence of multiple animal scanning on image quality for the Sedecal SuperArgus2R preclinical PET scanner. FRONTIERS IN PHYSICS. 2021;8.
IEEE
[1]
N. Efthimiou et al., “Influence of multiple animal scanning on image quality for the Sedecal SuperArgus2R preclinical PET scanner,” FRONTIERS IN PHYSICS, vol. 8, 2021.
@article{8686815,
  abstract     = {{Background: Increased throughput in small animal preclinical studies using positron emission tomography leads to reduced costs and improved efficiency of experimental design, however the presence of multiple off-centre subjects, as opposed to a single centered one, may affect image quality in several ways.

Methods: We evaluated the count rate performance using a NEMA scatter phantom. A Monte Carlo simulation of the system was validated against this dataset and used to simulate the count rate performance for dual scatter phantoms. NEMA NU4 image quality phantoms were then scanned in the central and offset positions, as well as in the offset position next to a uniform activity phantom. Uniformity, recovery coefficients and spillover ratios were then compared, as were two time frames for acquisition.

Results: Count rate performance assessed with a single NEMA scatter phantom was in line with previous literature, with simulated data in good agreement. Simulation of dual scatter phantoms showed an increase in scatter fraction. For the NEMA Image Quality phantom, uniformity and Recovery coefficients were degraded in the offset, and dual phantom cases, while spillover ratios were increased, notably when the chamber was placed nearest the gantry. Image quality metrics were comparable between the 20- and 10 min timeframes.

Conclusion: Dual animal scanning results in some loss of image quality on the Sedecal Argus PET scanner; however, this degradation is within acceptable limits.}},
  articleno    = {{531662}},
  author       = {{Efthimiou, Nikos and Wright, John D. and Clayton, Luke and Renard, Isaline and Zagni, Federico and De Vasconcelos Caribé, Paulo Rauli Rafeson and Archibald, Stephen J. and Cawthorne, Christopher J.}},
  issn         = {{2296-424X}},
  journal      = {{FRONTIERS IN PHYSICS}},
  keywords     = {{preclinical PET CT,dual phantom scanning,multiple animal scanning,Monte Carlo simulation,image quality,NEMA NU4,Sedecal Argus 2R,MICE,VALIDATION,SIMULATION}},
  language     = {{eng}},
  pages        = {{11}},
  title        = {{Influence of multiple animal scanning on image quality for the Sedecal SuperArgus2R preclinical PET scanner}},
  url          = {{http://dx.doi.org/10.3389/fphy.2020.531662}},
  volume       = {{8}},
  year         = {{2021}},
}

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