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Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis

(2019) NEONATOLOGY. 115(2). p.127-133
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Abstract
Background: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. Objectives: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. Methods: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1-42.6 weeks and birth weight 2,280-5,240 g) with proven sepsis (n = 14) and probable sepsis (n = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. Results: Sepsis was caused mostly by group B streptococci (n = 17), other Gram-positive bacteria (n = 5), and Candida albicans (n = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. Conclusion: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants. (c) 2018 The Author(s) Published by S. Karger AG, Basel
Keywords
Developmental Biology, Pediatrics, Perinatology, and Child Health, Early-onset sepsis, Perinatal asphyxia, Therapeutic hypothermia, Cerebral palsy, Neurodevelopmental impairment, Group B streptococcus, WHOLE-BODY HYPOTHERMIA, C-REACTIVE PROTEIN, NEONATAL ENCEPHALOPATHY, SYSTEMIC HYPOTHERMIA, INFECTION, TERM

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MLA
Hakobyan, Mariam, et al. “Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis.” NEONATOLOGY, vol. 115, no. 2, 2019, pp. 127–33, doi:10.1159/000493358.
APA
Hakobyan, M., Dijkman, K. P., Laroche, S., Naulaers, G., Rijken, M., Steiner, K., … Groenendaal, F. (2019). Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis. NEONATOLOGY, 115(2), 127–133. https://doi.org/10.1159/000493358
Chicago author-date
Hakobyan, Mariam, Koen P. Dijkman, Sabrina Laroche, Gunnar Naulaers, Monique Rijken, Katerina Steiner, Henrica L.M. van Straaten, et al. 2019. “Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis.” NEONATOLOGY 115 (2): 127–33. https://doi.org/10.1159/000493358.
Chicago author-date (all authors)
Hakobyan, Mariam, Koen P. Dijkman, Sabrina Laroche, Gunnar Naulaers, Monique Rijken, Katerina Steiner, Henrica L.M. van Straaten, Renate M.C. Swarte, Hendrik J. ter Horst, Aleksandra Zecic, Inge A. Zonnenberg, and Floris Groenendaal. 2019. “Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis.” NEONATOLOGY 115 (2): 127–133. doi:10.1159/000493358.
Vancouver
1.
Hakobyan M, Dijkman KP, Laroche S, Naulaers G, Rijken M, Steiner K, et al. Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis. NEONATOLOGY. 2019;115(2):127–33.
IEEE
[1]
M. Hakobyan et al., “Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis,” NEONATOLOGY, vol. 115, no. 2, pp. 127–133, 2019.
@article{8683566,
  abstract     = {{Background: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. Objectives: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. Methods: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1-42.6 weeks and birth weight 2,280-5,240 g) with proven sepsis (n = 14) and probable sepsis (n = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. Results: Sepsis was caused mostly by group B streptococci (n = 17), other Gram-positive bacteria (n = 5), and Candida albicans (n = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. Conclusion: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants. (c) 2018 The Author(s) Published by S. Karger AG, Basel}},
  author       = {{Hakobyan, Mariam and Dijkman, Koen P. and Laroche, Sabrina and Naulaers, Gunnar and Rijken, Monique and Steiner, Katerina and van Straaten, Henrica L.M. and Swarte, Renate M.C. and ter Horst, Hendrik J. and Zecic, Aleksandra and Zonnenberg, Inge A. and Groenendaal, Floris}},
  issn         = {{1661-7800}},
  journal      = {{NEONATOLOGY}},
  keywords     = {{Developmental Biology,Pediatrics,Perinatology,and Child Health,Early-onset sepsis,Perinatal asphyxia,Therapeutic hypothermia,Cerebral palsy,Neurodevelopmental impairment,Group B streptococcus,WHOLE-BODY HYPOTHERMIA,C-REACTIVE PROTEIN,NEONATAL ENCEPHALOPATHY,SYSTEMIC HYPOTHERMIA,INFECTION,TERM}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{127--133}},
  title        = {{Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis}},
  url          = {{http://dx.doi.org/10.1159/000493358}},
  volume       = {{115}},
  year         = {{2019}},
}

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