@article{8683426,
  abstract     = {{Postpartum dysgalactia syndrome (PPDS) is a major economic problem in modern sow farms. General treatment of PPDS consists of the use of oxytocin to promote milk ejection and non-steroidal anti-inflammatory drugs (NSAIDs) to alleviate inflammatory processes. So far, studies investigated the use of a single administration of NSAIDs after parturition in healthy and non-healthy sows. The current study investigated whether administration of meloxicam or paracetamol in sows prior to parturition improves sow and piglet health as well as performance in a farm with PPDS problems in sows. Sixty sows and 978 piglets from a Belgian farrow-to-finish farm were enrolled. Sows were randomly divided into three groups: a non-treated control group, a meloxicam-treated group and a paracetamol-treated group. Treatment was administered orally for 7 days from gestation day 113 onwards. Performance and health parameters investigated in sows were gestation length, farrowing duration, litter characteristics, colostrum yield and quality (Immunoglobulin G), litter weight gain, weaning-to-estrus interval, pregnancy rate, rectal temperature, acute phase proteins and inflammatory markers serum amyloid A, haptoglobin, interferon γ, interleukin 1β and 6 backfat, constipation and feed refusal. Performance and health parameters in piglets were birthweight, average daily weight gain, colostrum intake and mortality. Paracetamol-treated sows showed a significantly (P = 0.04) lower rectal temperature (mean ± SD: 38.09 ± 0.18°C) than the meloxicam-treated sows (38.24 ± 0.18°C), but not than the control group (38.22 ± 0.18°C). Sows of the paracetamol-treated group had a significantly (P = 0.001) longer gestation length (116.3 ± 0.9 days) than sows of the control group (115.3 ± 0.6 days), but not than meloxicam-treated sows (115.9 ± 0.9 days). No significant differences between the three groups were found for all the other parameters. In conclusion, the prophylactic oral administration of either meloxicam or paracetamol for 7 days starting 2 days prior to farrowing did not show beneficial effects on both health and performance parameters of sows and piglets.}},
  articleno    = {{603719}},
  author       = {{Schoos, Alexandra and Chantziaras, Ilias and Vandenabeele, Jordy and Biebaut, Evelien and Meyer, Evelyne and Cools, An and Devreese, Mathias and Maes, Dominiek}},
  issn         = {{2297-1769}},
  journal      = {{FRONTIERS IN VETERINARY SCIENCE}},
  keywords     = {{NSAID,acetaminophen,sow,inflammation,fever,PPDS,prophylaxis,piglet,ACUTE-PHASE PROTEINS,COLOSTRUM YIELD,METRITIS-AGALACTIA,PIGLET MORTALITY,SERUM CORTISOL,RISK-FACTORS,PERFORMANCE,KETOPROFEN,MASTITIS,IMPACT}},
  language     = {{eng}},
  pages        = {{14}},
  title        = {{Prophylactic use of meloxicam and paracetamol in peripartal sows suffering from postpartum dysgalactia syndrome}},
  url          = {{http://doi.org/10.3389/fvets.2020.603719}},
  volume       = {{7}},
  year         = {{2020}},
}

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