Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 2.24 MB
Add to list
  1. Search results
  2. Intrinsic balance between ZEB family ...

Intrinsic balance between ZEB family members is important for melanocyte homeostasis and melanoma progression

Kenneth Bruneel (UGent) , Jeroen Verstappe (UGent) , Niels Vandamme (UGent) and Geert Berx (UGent)
(2020) CANCERS. 12(8).
Author
Organization
Abstract
It has become clear that cellular plasticity is a main driver of cancer therapy resistance. Consequently, there is a need to mechanistically identify the factors driving this process. The transcription factors of the zinc-finger E-box-binding homeobox family, consisting of ZEB1 and ZEB2, are notorious for their roles in epithelial-to-mesenchymal transition (EMT). However, in melanoma, an intrinsic balance between ZEB1 and ZEB2 seems to determine the cellular state by modulating the expression of the master regulator of melanocyte homeostasis, microphthalmia-associated transcription factor (MITF). ZEB2 drives MITF expression and is associated with a differentiated/proliferative melanoma cell state. On the other hand, ZEB1 is correlated with low MITF expression and a more invasive, stem cell-like and therapy-resistant cell state. This intrinsic balance between ZEB1 and ZEB2 could prove to be a promising therapeutic target for melanoma patients. In this review, we will summarise what is known on the functional mechanisms of these transcription factors. Moreover, we will look specifically at their roles during melanocyte-lineage development and homeostasis. Finally, we will overview the current literature on ZEB1 and ZEB2 in the melanoma context and link this to the 'phenotype-switching' model of melanoma cellular plasticity.
Keywords
SMAD-INTERACTING PROTEIN-1, REGULATES E-CADHERIN, EPITHELIAL-MESENCHYMAL, TRANSITION, HOMEODOMAIN TRANSCRIPTION FACTOR, GROWTH-FACTOR-BETA, ZINC-FINGER, GENE-EXPRESSION, STEM-CELLS, PHENOTYPIC PLASTICITY, BINDING-PROTEIN, ZEB transcription factors, melanoma, melanocyte development and, homeostasis, phenotype switching, tumour heterogeneity, cellular, plasticity

Downloads

  • Download
    4400 20Bruneel.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 2.24 MB

Citation

Please use this url to cite or link to this publication:

MLA
Bruneel, Kenneth, et al. “Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression.” CANCERS, vol. 12, no. 8, Mdpi, 2020, doi:10.3390/cancers12082248.
APA
Bruneel, K., Verstappe, J., Vandamme, N., & Berx, G. (2020). Intrinsic balance between ZEB family members is important for melanocyte homeostasis and melanoma progression. CANCERS, 12(8). https://doi.org/10.3390/cancers12082248
Chicago author-date
Bruneel, Kenneth, Jeroen Verstappe, Niels Vandamme, and Geert Berx. 2020. “Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression.” CANCERS 12 (8). https://doi.org/10.3390/cancers12082248.
Chicago author-date (all authors)
Bruneel, Kenneth, Jeroen Verstappe, Niels Vandamme, and Geert Berx. 2020. “Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression.” CANCERS 12 (8). doi:10.3390/cancers12082248.
Vancouver
1.
Bruneel K, Verstappe J, Vandamme N, Berx G. Intrinsic balance between ZEB family members is important for melanocyte homeostasis and melanoma progression. CANCERS. 2020;12(8).
IEEE
[1]
K. Bruneel, J. Verstappe, N. Vandamme, and G. Berx, “Intrinsic balance between ZEB family members is important for melanocyte homeostasis and melanoma progression,” CANCERS, vol. 12, no. 8, 2020.
@article{8683120,
  abstract     = {{It has become clear that cellular plasticity is a main driver of cancer therapy resistance. Consequently, there is a need to mechanistically identify the factors driving this process. The transcription factors of the zinc-finger E-box-binding homeobox family, consisting of ZEB1 and ZEB2, are notorious for their roles in epithelial-to-mesenchymal transition (EMT). However, in melanoma, an intrinsic balance between ZEB1 and ZEB2 seems to determine the cellular state by modulating the expression of the master regulator of melanocyte homeostasis, microphthalmia-associated transcription factor (MITF). ZEB2 drives MITF expression and is associated with a differentiated/proliferative melanoma cell state. On the other hand, ZEB1 is correlated with low MITF expression and a more invasive, stem cell-like and therapy-resistant cell state. This intrinsic balance between ZEB1 and ZEB2 could prove to be a promising therapeutic target for melanoma patients. In this review, we will summarise what is known on the functional mechanisms of these transcription factors. Moreover, we will look specifically at their roles during melanocyte-lineage development and homeostasis. Finally, we will overview the current literature on ZEB1 and ZEB2 in the melanoma context and link this to the 'phenotype-switching' model of melanoma cellular plasticity.}},
  articleno    = {{2248}},
  author       = {{Bruneel, Kenneth and Verstappe, Jeroen and Vandamme, Niels and Berx, Geert}},
  issn         = {{2072-6694}},
  journal      = {{CANCERS}},
  keywords     = {{SMAD-INTERACTING PROTEIN-1,REGULATES E-CADHERIN,EPITHELIAL-MESENCHYMAL,TRANSITION,HOMEODOMAIN TRANSCRIPTION FACTOR,GROWTH-FACTOR-BETA,ZINC-FINGER,GENE-EXPRESSION,STEM-CELLS,PHENOTYPIC PLASTICITY,BINDING-PROTEIN,ZEB transcription factors,melanoma,melanocyte development and,homeostasis,phenotype switching,tumour heterogeneity,cellular,plasticity}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{25}},
  publisher    = {{Mdpi}},
  title        = {{Intrinsic balance between ZEB family members is important for melanocyte homeostasis and melanoma progression}},
  url          = {{http://dx.doi.org/10.3390/cancers12082248}},
  volume       = {{12}},
  year         = {{2020}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: