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Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism

Maria Mar Marquès-Bueno, Laia Armengot, Lise C. Noack, Joseph Bareille, Lesia Rodriguez, Matthieu Pierre Platre, Vincent Bayle, Mengying Liu, Davy Opdenacker (UGent) , Steffen Vanneste (UGent) , et al.
(2021) CURRENT BIOLOGY. 31(1). p.228-237.e10
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Abstract
Plants are able to orient their growth according to gravity, which ultimately controls both shoot and root architecture.1 Gravitropism is a dynamic process whereby gravistimulation induces the asymmetric distribution of the plant hormone auxin, leading to asymmetric growth, organ bending, and subsequent reset of auxin distribution back to the original pre-gravistimulation situation.1-3 Differential auxin accumulation during the gravitropic response depends on the activity of polarly localized PIN-FORMED (PIN) auxin-efflux carriers.1-4 In particular, the timing of this dynamic response is regulated by PIN2,5,6 but the underlying molecular mechanisms are poorly understood. Here, we show that MEMBRANE ASSOCIATED KINASE REGULATOR2 (MAKR2) controls the pace of the root gravitropic response. We found that MAKR2 is required for the PIN2 asymmetry during gravitropism by acting as a negative regulator of the cell-surface signaling mediated by the receptor-like kinase TRANSMEMBRANE KINASE1 (TMK1).2,7-10 Furthermore, we show that the MAKR2 inhibitory effect on TMK1 signaling is antagonized by auxin itself, which triggers rapid MAKR2 membrane dissociation in a TMK1-dependent manner. Our findings suggest that the timing of the root gravitropic response is orchestrated by the reversible inhibition of the TMK1 signaling pathway at the cell surface.
Keywords
MAKR, ROP6, TMK, anionic lipids, auxin, brassinosteroid, gravitropism, receptor-like kinase, root, RECEPTOR-LIKE KINASES, INTRACELLULAR TRAFFICKING, CELL-SURFACE, ARABIDOPSIS, PROTEIN, ENDOCYTOSIS, EFFLUX, ABP1, RHO, EXPRESSION

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MLA
Marquès-Bueno, Maria Mar, et al. “Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism.” CURRENT BIOLOGY, vol. 31, no. 1, 2021, pp. 228-237.e10, doi:10.1016/j.cub.2020.10.011.
APA
Marquès-Bueno, M. M., Armengot, L., Noack, L. C., Bareille, J., Rodriguez, L., Platre, M. P., … Jaillais, Y. (2021). Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism. CURRENT BIOLOGY, 31(1), 228-237.e10. https://doi.org/10.1016/j.cub.2020.10.011
Chicago author-date
Marquès-Bueno, Maria Mar, Laia Armengot, Lise C. Noack, Joseph Bareille, Lesia Rodriguez, Matthieu Pierre Platre, Vincent Bayle, et al. 2021. “Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism.” CURRENT BIOLOGY 31 (1): 228-237.e10. https://doi.org/10.1016/j.cub.2020.10.011.
Chicago author-date (all authors)
Marquès-Bueno, Maria Mar, Laia Armengot, Lise C. Noack, Joseph Bareille, Lesia Rodriguez, Matthieu Pierre Platre, Vincent Bayle, Mengying Liu, Davy Opdenacker, Steffen Vanneste, Barbara Möller, Zachary L. Nimchuk, Tom Beeckman, Ana I. Caño-Delgado, Jiří Friml, and Yvon Jaillais. 2021. “Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism.” CURRENT BIOLOGY 31 (1): 228-237.e10. doi:10.1016/j.cub.2020.10.011.
Vancouver
1.
Marquès-Bueno MM, Armengot L, Noack LC, Bareille J, Rodriguez L, Platre MP, et al. Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism. CURRENT BIOLOGY. 2021;31(1):228-237.e10.
IEEE
[1]
M. M. Marquès-Bueno et al., “Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism,” CURRENT BIOLOGY, vol. 31, no. 1, pp. 228-237.e10, 2021.
@article{8682258,
  abstract     = {{Plants are able to orient their growth according to gravity, which ultimately controls both shoot and root architecture.1 Gravitropism is a dynamic process whereby gravistimulation induces the asymmetric distribution of the plant hormone auxin, leading to asymmetric growth, organ bending, and subsequent reset of auxin distribution back to the original pre-gravistimulation situation.1-3 Differential auxin accumulation during the gravitropic response depends on the activity of polarly localized PIN-FORMED (PIN) auxin-efflux carriers.1-4 In particular, the timing of this dynamic response is regulated by PIN2,5,6 but the underlying molecular mechanisms are poorly understood. Here, we show that MEMBRANE ASSOCIATED KINASE REGULATOR2 (MAKR2) controls the pace of the root gravitropic response. We found that MAKR2 is required for the PIN2 asymmetry during gravitropism by acting as a negative regulator of the cell-surface signaling mediated by the receptor-like kinase TRANSMEMBRANE KINASE1 (TMK1).2,7-10 Furthermore, we show that the MAKR2 inhibitory effect on TMK1 signaling is antagonized by auxin itself, which triggers rapid MAKR2 membrane dissociation in a TMK1-dependent manner. Our findings suggest that the timing of the root gravitropic response is orchestrated by the reversible inhibition of the TMK1 signaling pathway at the cell surface.}},
  author       = {{Marquès-Bueno, Maria Mar and Armengot, Laia and Noack, Lise C. and Bareille, Joseph and Rodriguez, Lesia and Platre, Matthieu Pierre and Bayle, Vincent and Liu, Mengying and Opdenacker, Davy and Vanneste, Steffen and Möller, Barbara and Nimchuk, Zachary L. and Beeckman, Tom and Caño-Delgado, Ana I. and Friml, Jiří and Jaillais, Yvon}},
  issn         = {{0960-9822}},
  journal      = {{CURRENT BIOLOGY}},
  keywords     = {{MAKR,ROP6,TMK,anionic lipids,auxin,brassinosteroid,gravitropism,receptor-like kinase,root,RECEPTOR-LIKE KINASES,INTRACELLULAR TRAFFICKING,CELL-SURFACE,ARABIDOPSIS,PROTEIN,ENDOCYTOSIS,EFFLUX,ABP1,RHO,EXPRESSION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{228--237.e10}},
  title        = {{Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism}},
  url          = {{http://doi.org/10.1016/j.cub.2020.10.011}},
  volume       = {{31}},
  year         = {{2021}},
}
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