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Bioenergetics of the VO2 slow component between exercise intensity domains

Alessandro Colosio (UGent) , Kevin Caen (UGent) , Jan Bourgois (UGent) , Jan Boone (UGent) and Silvia Pogliaghi
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Abstract
During heavy and severe constant-load exercise, VO(2)displays a slow component (VO2sc) typically interpreted as a loss of efficiency of locomotion. In the ongoing debate on the underpinnings of the VO2sc, recent studies suggested that VO(2sc)could be attributed to a prolonged shift in energetic sources rather than loss of efficiency. We tested the hypothesis that the total cost of cycling, accounting for aerobic and anaerobic energy sources, is affected by time during metabolic transitions in different intensity domains. Eight active men performed 3 constant load trials of 3, 6, and 9 min in the moderate, heavy, and severe domains (i.e., respectively below, between, and above the two ventilatory thresholds). VO2, VO(2)of ventilation and lactate accumulation ([La-]) were quantified to calculate the adjusted oxygen cost of exercise (AdjO(2Eq), i.e., measured VO2 - VO(2)of ventilation + VO(2)equivalent of [La-]) for the 0-3, 3-6, and 6-9 time segments at each intensity, and compared by a two-way RM-ANOVA (time x intensity). After the transient phase, AdjO(2Eq)was unaffected by time in moderate (ml*3 min(-1)at 0-3, 0-6, 0-9 min: 2126 +/- 939 < 2687 +/- 1036, 2731 +/- 1035) and heavy (4278 +/- 1074 < 5121 +/- 1268, 5225 +/- 1123) while a significant effect of time was detected in the severe only (5863 +/- 1413 < 7061 +/- 1516 < 7372 +/- 1443). The emergence of the VO(2sc)was explained by a prolonged shift between aerobic and anaerobic energy sources in heavy (VO2 - VO(2)of ventilation: ml*3 min(-1)at 0-3, 0-6, 0-9 min: 3769 +/- 1128 < 4938 +/- 1256, 5091 +/- 1123, [La-]: 452 +/- 254 < 128 +/- 169, 79 +/- 135), while a prolonged metabolic shift and a true loss of efficiency explained the emergence of the VO(2sc)in severe.
Keywords
Oxidative metabolism, VO2 kinetics, Exercise physiology, Oxygen consumption, Excess VO2, Loss of efficiency, SLOW COMPONENT, OXYGEN-UPTAKE, UPTAKE KINETICS, RECRUITMENT, METABOLISM, OLDER, WORK

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MLA
Colosio, Alessandro, et al. “Bioenergetics of the VO2 Slow Component between Exercise Intensity Domains.” PFLUGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY, vol. 472, no. 10, 2020, pp. 1447–56, doi:10.1007/s00424-020-02437-7.
APA
Colosio, A., Caen, K., Bourgois, J., Boone, J., & Pogliaghi, S. (2020). Bioenergetics of the VO2 slow component between exercise intensity domains. PFLUGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY, 472(10), 1447–1456. https://doi.org/10.1007/s00424-020-02437-7
Chicago author-date
Colosio, Alessandro, Kevin Caen, Jan Bourgois, Jan Boone, and Silvia Pogliaghi. 2020. “Bioenergetics of the VO2 Slow Component between Exercise Intensity Domains.” PFLUGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY 472 (10): 1447–56. https://doi.org/10.1007/s00424-020-02437-7.
Chicago author-date (all authors)
Colosio, Alessandro, Kevin Caen, Jan Bourgois, Jan Boone, and Silvia Pogliaghi. 2020. “Bioenergetics of the VO2 Slow Component between Exercise Intensity Domains.” PFLUGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY 472 (10): 1447–1456. doi:10.1007/s00424-020-02437-7.
Vancouver
1.
Colosio A, Caen K, Bourgois J, Boone J, Pogliaghi S. Bioenergetics of the VO2 slow component between exercise intensity domains. PFLUGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY. 2020;472(10):1447–56.
IEEE
[1]
A. Colosio, K. Caen, J. Bourgois, J. Boone, and S. Pogliaghi, “Bioenergetics of the VO2 slow component between exercise intensity domains,” PFLUGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY, vol. 472, no. 10, pp. 1447–1456, 2020.
@article{8681183,
  abstract     = {{During heavy and severe constant-load exercise, VO(2)displays a slow component (VO2sc) typically interpreted as a loss of efficiency of locomotion. In the ongoing debate on the underpinnings of the VO2sc, recent studies suggested that VO(2sc)could be attributed to a prolonged shift in energetic sources rather than loss of efficiency. We tested the hypothesis that the total cost of cycling, accounting for aerobic and anaerobic energy sources, is affected by time during metabolic transitions in different intensity domains. Eight active men performed 3 constant load trials of 3, 6, and 9 min in the moderate, heavy, and severe domains (i.e., respectively below, between, and above the two ventilatory thresholds). VO2, VO(2)of ventilation and lactate accumulation ([La-]) were quantified to calculate the adjusted oxygen cost of exercise (AdjO(2Eq), i.e., measured VO2 - VO(2)of ventilation + VO(2)equivalent of [La-]) for the 0-3, 3-6, and 6-9 time segments at each intensity, and compared by a two-way RM-ANOVA (time x intensity). After the transient phase, AdjO(2Eq)was unaffected by time in moderate (ml*3 min(-1)at 0-3, 0-6, 0-9 min: 2126 +/- 939 < 2687 +/- 1036, 2731 +/- 1035) and heavy (4278 +/- 1074 < 5121 +/- 1268, 5225 +/- 1123) while a significant effect of time was detected in the severe only (5863 +/- 1413 < 7061 +/- 1516 < 7372 +/- 1443). The emergence of the VO(2sc)was explained by a prolonged shift between aerobic and anaerobic energy sources in heavy (VO2 - VO(2)of ventilation: ml*3 min(-1)at 0-3, 0-6, 0-9 min: 3769 +/- 1128 < 4938 +/- 1256, 5091 +/- 1123, [La-]: 452 +/- 254 < 128 +/- 169, 79 +/- 135), while a prolonged metabolic shift and a true loss of efficiency explained the emergence of the VO(2sc)in severe.}},
  author       = {{Colosio, Alessandro and Caen, Kevin and Bourgois, Jan and Boone, Jan and Pogliaghi, Silvia}},
  issn         = {{0031-6768}},
  journal      = {{PFLUGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY}},
  keywords     = {{Oxidative metabolism,VO2 kinetics,Exercise physiology,Oxygen consumption,Excess VO2,Loss of efficiency,SLOW COMPONENT,OXYGEN-UPTAKE,UPTAKE KINETICS,RECRUITMENT,METABOLISM,OLDER,WORK}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1447--1456}},
  title        = {{Bioenergetics of the VO2 slow component between exercise intensity domains}},
  url          = {{http://dx.doi.org/10.1007/s00424-020-02437-7}},
  volume       = {{472}},
  year         = {{2020}},
}

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