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Association between lipoprotein lipase gene polymorphisms and cardiovascular disease risk factors in European adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence study

(2020) PEDIATRIC DIABETES. 21(5). p.747-757
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Abstract
Objectives To examine the association of lipoprotein lipase (LPL) polymorphisms with cardiovascular disease (CVD) risk factors in European adolescents, along with the influence of physical activity on these associations. Methods A total of 13 LPL polymorphisms were genotyped in 1.057 European adolescents (12-18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. Serum lipids, glucose, insulin, and leptin (LEP) levels were measured and a CVD risk score was computed. We also measured body weight and height, waist and hip circumferences, and triceps and subscapular skinfold thickness. Physical activity was objectively measured by accelerometry for 7 days. Results The rs1534649, rs258, rs320, and rs328 polymorphisms were associated with several CVD risk factors (ie, body mass index, triglycerides [TG], LEP, and cholesterol/high-density lipoprotein [HDL], low-density lipoprotein [LDL]/HDL, TG/HDL ratios). TG and TG/HDL were associated with haplotype blocks 3 (rs282, rs285 polymorphisms) and 4 (rs3126, rs320, rs328, rs10099160 polymorphisms), being the latter also associated with the CVD risk score. Physical activity modulated the association of adiposity with rs1534649 and rs258 polymorphisms. Conclusions Polymorphisms rs1534649, rs258, rs320 and rs328, and two haplotypes of LPL were significantly associated with CVD risk factors in European adolescents. Higher levels of moderate to vigorous physical activity may attenuate the effects of rs1534649 and rs258 polymorphisms on adiposity.
Keywords
Pediatrics, Perinatology, and Child Health, Internal Medicine, Endocrinology, Diabetes and Metabolism, adolescents, cardiovascular disease, genetic susceptibility, LPL, physical activity, PHYSICAL-ACTIVITY, CARDIORESPIRATORY FITNESS, STROKE, LPL, POPULATION, OVERWEIGHT, HAPLOTYPE, CHILDREN, OBESITY, POWER

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MLA
Salazar‐Tortosa, Diego F., et al. “Association between Lipoprotein Lipase Gene Polymorphisms and Cardiovascular Disease Risk Factors in European Adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence Study.” PEDIATRIC DIABETES, vol. 21, no. 5, 2020, pp. 747–57, doi:10.1111/pedi.13035.
APA
Salazar‐Tortosa, D. F., Pascual‐Gamarra, J. M., Labayen, I., Rupérez, A. I., Censi, L., Béghin, L., … Ruiz, J. R. (2020). Association between lipoprotein lipase gene polymorphisms and cardiovascular disease risk factors in European adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence study. PEDIATRIC DIABETES, 21(5), 747–757. https://doi.org/10.1111/pedi.13035
Chicago author-date
Salazar‐Tortosa, Diego F., Jose M. Pascual‐Gamarra, Idoia Labayen, Azahara I. Rupérez, Laura Censi, Laurent Béghin, Nathalie Michels, et al. 2020. “Association between Lipoprotein Lipase Gene Polymorphisms and Cardiovascular Disease Risk Factors in European Adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence Study.” PEDIATRIC DIABETES 21 (5): 747–57. https://doi.org/10.1111/pedi.13035.
Chicago author-date (all authors)
Salazar‐Tortosa, Diego F., Jose M. Pascual‐Gamarra, Idoia Labayen, Azahara I. Rupérez, Laura Censi, Laurent Béghin, Nathalie Michels, Marcela Gonzalez‐Gross, Yannis Manios, Christina‐Paulina Lambrinou, Ascension Marcos, Luis A. Moreno, Aline Meirhaeghe, Manuel J. Castillo, and Jonatan R. Ruiz. 2020. “Association between Lipoprotein Lipase Gene Polymorphisms and Cardiovascular Disease Risk Factors in European Adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence Study.” PEDIATRIC DIABETES 21 (5): 747–757. doi:10.1111/pedi.13035.
Vancouver
1.
Salazar‐Tortosa DF, Pascual‐Gamarra JM, Labayen I, Rupérez AI, Censi L, Béghin L, et al. Association between lipoprotein lipase gene polymorphisms and cardiovascular disease risk factors in European adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence study. PEDIATRIC DIABETES. 2020;21(5):747–57.
IEEE
[1]
D. F. Salazar‐Tortosa et al., “Association between lipoprotein lipase gene polymorphisms and cardiovascular disease risk factors in European adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence study,” PEDIATRIC DIABETES, vol. 21, no. 5, pp. 747–757, 2020.
@article{8680884,
  abstract     = {Objectives To examine the association of lipoprotein lipase (LPL) polymorphisms with cardiovascular disease (CVD) risk factors in European adolescents, along with the influence of physical activity on these associations.

Methods A total of 13 LPL polymorphisms were genotyped in 1.057 European adolescents (12-18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. Serum lipids, glucose, insulin, and leptin (LEP) levels were measured and a CVD risk score was computed. We also measured body weight and height, waist and hip circumferences, and triceps and subscapular skinfold thickness. Physical activity was objectively measured by accelerometry for 7 days.

Results The rs1534649, rs258, rs320, and rs328 polymorphisms were associated with several CVD risk factors (ie, body mass index, triglycerides [TG], LEP, and cholesterol/high-density lipoprotein [HDL], low-density lipoprotein [LDL]/HDL, TG/HDL ratios). TG and TG/HDL were associated with haplotype blocks 3 (rs282, rs285 polymorphisms) and 4 (rs3126, rs320, rs328, rs10099160 polymorphisms), being the latter also associated with the CVD risk score. Physical activity modulated the association of adiposity with rs1534649 and rs258 polymorphisms.

Conclusions Polymorphisms rs1534649, rs258, rs320 and rs328, and two haplotypes of LPL were significantly associated with CVD risk factors in European adolescents. Higher levels of moderate to vigorous physical activity may attenuate the effects of rs1534649 and rs258 polymorphisms on adiposity.},
  author       = {Salazar‐Tortosa, Diego F. and Pascual‐Gamarra, Jose M. and Labayen, Idoia and Rupérez, Azahara I. and Censi, Laura and Béghin, Laurent and Michels, Nathalie and Gonzalez‐Gross, Marcela and Manios, Yannis and Lambrinou, Christina‐Paulina and Marcos, Ascension and Moreno, Luis A. and Meirhaeghe, Aline and Castillo, Manuel J. and Ruiz, Jonatan R.},
  issn         = {1399-543X},
  journal      = {PEDIATRIC DIABETES},
  keywords     = {Pediatrics,Perinatology,and Child Health,Internal Medicine,Endocrinology,Diabetes and Metabolism,adolescents,cardiovascular disease,genetic susceptibility,LPL,physical activity,PHYSICAL-ACTIVITY,CARDIORESPIRATORY FITNESS,STROKE,LPL,POPULATION,OVERWEIGHT,HAPLOTYPE,CHILDREN,OBESITY,POWER},
  language     = {eng},
  number       = {5},
  pages        = {747--757},
  title        = {Association between lipoprotein lipase gene polymorphisms and cardiovascular disease risk factors in European adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence study},
  url          = {http://dx.doi.org/10.1111/pedi.13035},
  volume       = {21},
  year         = {2020},
}

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