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Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents : the Healthy Lifestyle in Europe by Nutrition in Adolescence study

Diego F. Salazar-Tortosa, Jose M. Pascual-Gamarra, Idoia Labayen, Azahara I. Rupérez, Laura Censi, Laurent Béghin, Nathalie Michels (UGent) , Marcela González-Gross, Yannis Manios, Christina-Paulina Lambrinou, et al.
(2020) JOURNAL OF HYPERTENSION. 38(10). p.1971-1979
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Abstract
Objectives: Cardiovascular diseases (CVDs) are responsible of 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. Aims of present research are to examine the association of ADIPOQ gene polymorphisms with cardiovascular disease risk factors in European adolescents. Methods: A total of 14 polymorphisms in the ADIPOQ gene were genotyped in 1057 European adolescents (12-18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. We measured serum lipids and a CVD risk score, along with weight, height, triceps, and subscapular skinfold thickness, leptin, insulin and other markers of glucose regulation. Results: The rs822393, rs822395 and rs7649121 polymorphisms of ADIPOQ gene were significantly associated with several CVD risk factors [i.e. high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1, SBP and CVD risk score] in European adolescents. We also found an association of the TGAAGT ADIPOQ haplotype (rs822393, rs16861210, rs822395, rs822396, rs12495941 and rs7649121) with HDL-C and ApoA1 levels. Conclusion: Several individual polymorphisms (rs822393, rs822395 and rs7649121) and a haplotype of ADIPOQ gene were significantly associated with cardiovascular disease risk factors in European adolescents.
Keywords
Internal Medicine, Physiology, Cardiology and Cardiovascular Medicine, ADIPOQ, adolescents, cardiovascular disease, genetic susceptibility, single nucleotide polymorphism, INSULIN-RESISTANCE, ADIPONECTIN, MULTICENTER, FITNESS

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MLA
Salazar-Tortosa, Diego F., et al. “Single Nucleotide Polymorphisms of ADIPOQ Gene Associated with Cardiovascular Disease Risk Factors in European Adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence Study.” JOURNAL OF HYPERTENSION, vol. 38, no. 10, 2020, pp. 1971–79, doi:10.1097/hjh.0000000000002502.
APA
Salazar-Tortosa, D. F., Pascual-Gamarra, J. M., Labayen, I., Rupérez, A. I., Censi, L., Béghin, L., … Ruiz, J. R. (2020). Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents : the Healthy Lifestyle in Europe by Nutrition in Adolescence study. JOURNAL OF HYPERTENSION, 38(10), 1971–1979. https://doi.org/10.1097/hjh.0000000000002502
Chicago author-date
Salazar-Tortosa, Diego F., Jose M. Pascual-Gamarra, Idoia Labayen, Azahara I. Rupérez, Laura Censi, Laurent Béghin, Nathalie Michels, et al. 2020. “Single Nucleotide Polymorphisms of ADIPOQ Gene Associated with Cardiovascular Disease Risk Factors in European Adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence Study.” JOURNAL OF HYPERTENSION 38 (10): 1971–79. https://doi.org/10.1097/hjh.0000000000002502.
Chicago author-date (all authors)
Salazar-Tortosa, Diego F., Jose M. Pascual-Gamarra, Idoia Labayen, Azahara I. Rupérez, Laura Censi, Laurent Béghin, Nathalie Michels, Marcela González-Gross, Yannis Manios, Christina-Paulina Lambrinou, Luis A. Moreno, Aline Meirhaeghe, Manuel J. Castillo, and Jonatan R. Ruiz. 2020. “Single Nucleotide Polymorphisms of ADIPOQ Gene Associated with Cardiovascular Disease Risk Factors in European Adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence Study.” JOURNAL OF HYPERTENSION 38 (10): 1971–1979. doi:10.1097/hjh.0000000000002502.
Vancouver
1.
Salazar-Tortosa DF, Pascual-Gamarra JM, Labayen I, Rupérez AI, Censi L, Béghin L, et al. Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents : the Healthy Lifestyle in Europe by Nutrition in Adolescence study. JOURNAL OF HYPERTENSION. 2020;38(10):1971–9.
IEEE
[1]
D. F. Salazar-Tortosa et al., “Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents : the Healthy Lifestyle in Europe by Nutrition in Adolescence study,” JOURNAL OF HYPERTENSION, vol. 38, no. 10, pp. 1971–1979, 2020.
@article{8680882,
  abstract     = {{Objectives: Cardiovascular diseases (CVDs) are responsible of 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. Aims of present research are to examine the association of ADIPOQ gene polymorphisms with cardiovascular disease risk factors in European adolescents. Methods: A total of 14 polymorphisms in the ADIPOQ gene were genotyped in 1057 European adolescents (12-18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. We measured serum lipids and a CVD risk score, along with weight, height, triceps, and subscapular skinfold thickness, leptin, insulin and other markers of glucose regulation. Results: The rs822393, rs822395 and rs7649121 polymorphisms of ADIPOQ gene were significantly associated with several CVD risk factors [i.e. high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1, SBP and CVD risk score] in European adolescents. We also found an association of the TGAAGT ADIPOQ haplotype (rs822393, rs16861210, rs822395, rs822396, rs12495941 and rs7649121) with HDL-C and ApoA1 levels. Conclusion: Several individual polymorphisms (rs822393, rs822395 and rs7649121) and a haplotype of ADIPOQ gene were significantly associated with cardiovascular disease risk factors in European adolescents.}},
  author       = {{Salazar-Tortosa, Diego F. and Pascual-Gamarra, Jose M. and Labayen, Idoia and Rupérez, Azahara I. and Censi, Laura and Béghin, Laurent and Michels, Nathalie and González-Gross, Marcela and Manios, Yannis and Lambrinou, Christina-Paulina and Moreno, Luis A. and Meirhaeghe, Aline and Castillo, Manuel J. and Ruiz, Jonatan R.}},
  issn         = {{0263-6352}},
  journal      = {{JOURNAL OF HYPERTENSION}},
  keywords     = {{Internal Medicine,Physiology,Cardiology and Cardiovascular Medicine,ADIPOQ,adolescents,cardiovascular disease,genetic susceptibility,single nucleotide polymorphism,INSULIN-RESISTANCE,ADIPONECTIN,MULTICENTER,FITNESS}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1971--1979}},
  title        = {{Single nucleotide polymorphisms of ADIPOQ gene associated with cardiovascular disease risk factors in European adolescents : the Healthy Lifestyle in Europe by Nutrition in Adolescence study}},
  url          = {{http://doi.org/10.1097/hjh.0000000000002502}},
  volume       = {{38}},
  year         = {{2020}},
}
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