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Chronic inflammation towards cancer incidence : a systematic review and meta-analysis of epidemiological studies

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Abstract
This systematic review and meta-analysis provides epidemiological data on the relationship between chronic inflammation, as measured by inflammatory blood parameters, and cancer incidence. Two independent researchers searched PubMed, Web Of Science and Embase databases until October 2020. In vitro studies, animal studies, studies with chronically-ill subjects or cross-sectional studies were excluded. Quality was assessed with the Newcastle-Ottawa scale. The 59 nested case-control, 6 nested case-cohort and 42 prospective cohort studies considered 119 different inflammatory markers (top three: CRP, fibrinogen and IL6) and 26 cancer types (top five: colorectal, lung, breast, overall and prostate cancer). Nineteen meta-analyses resulted in ten significant positive associations: CRP-breast (OR = 1.23[1.05-1.43];HR = 1.14[1.01-1.28)), CRP-colorectal (OR = 1.34 [1.11-1.60]), CRP-lung (HR = 2.03[1.59-2.60]), fibrinogen-lung (OR = 2.56[1.86-3.54]), IL6-lung (OR = 1.41 [1.12-1.78]), CRP-ovarian (OR = 1.41[1.10-1.80]), CRP-prostate (HR = 1.09[1.03-1.15]), CRP-overall (HR = 1.35[1.16-1.57]) and fibrinogen-overall (OR = 1.22[1.07-1.39]). Study quality improvements can be done by better verification of inflammatory status (more than one baseline measurement of one parameter), adjusting for important confounders and ensuring long-term follow-up.
Keywords
Oncology, Geriatrics and Gerontology, Hematology, General Medicine, Cancer, Cytokines, Inflammatory markers, Observational studies, Systematic review, C-REACTIVE PROTEIN, PREDIAGNOSTIC SERUM-LEVELS, OBESITY-RELATED CANCERS, NON-HODGKIN-LYMPHOMA, COLORECTAL-CANCER, OVARIAN-CANCER, BREAST-CANCER, PROSTATE-CANCER, PANCREATIC-CANCER, GASTRIC-CANCER

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MLA
Michels, Nathalie, et al. “Chronic Inflammation towards Cancer Incidence : A Systematic Review and Meta-Analysis of Epidemiological Studies.” CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, vol. 157, 2021, doi:10.1016/j.critrevonc.2020.103177.
APA
Michels, N., van Aart, C., Morisse, J., Mullee, A., & Huybrechts, I. (2021). Chronic inflammation towards cancer incidence : a systematic review and meta-analysis of epidemiological studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 157. https://doi.org/10.1016/j.critrevonc.2020.103177
Chicago author-date
Michels, Nathalie, Carola van Aart, Jens Morisse, Amy Mullee, and Inge Huybrechts. 2021. “Chronic Inflammation towards Cancer Incidence : A Systematic Review and Meta-Analysis of Epidemiological Studies.” CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 157. https://doi.org/10.1016/j.critrevonc.2020.103177.
Chicago author-date (all authors)
Michels, Nathalie, Carola van Aart, Jens Morisse, Amy Mullee, and Inge Huybrechts. 2021. “Chronic Inflammation towards Cancer Incidence : A Systematic Review and Meta-Analysis of Epidemiological Studies.” CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 157. doi:10.1016/j.critrevonc.2020.103177.
Vancouver
1.
Michels N, van Aart C, Morisse J, Mullee A, Huybrechts I. Chronic inflammation towards cancer incidence : a systematic review and meta-analysis of epidemiological studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2021;157.
IEEE
[1]
N. Michels, C. van Aart, J. Morisse, A. Mullee, and I. Huybrechts, “Chronic inflammation towards cancer incidence : a systematic review and meta-analysis of epidemiological studies,” CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, vol. 157, 2021.
@article{8680870,
  abstract     = {{This systematic review and meta-analysis provides epidemiological data on the relationship between chronic inflammation, as measured by inflammatory blood parameters, and cancer incidence. Two independent researchers searched PubMed, Web Of Science and Embase databases until October 2020. In vitro studies, animal studies, studies with chronically-ill subjects or cross-sectional studies were excluded. Quality was assessed with the Newcastle-Ottawa scale. The 59 nested case-control, 6 nested case-cohort and 42 prospective cohort studies considered 119 different inflammatory markers (top three: CRP, fibrinogen and IL6) and 26 cancer types (top five: colorectal, lung, breast, overall and prostate cancer). Nineteen meta-analyses resulted in ten significant positive associations: CRP-breast (OR = 1.23[1.05-1.43];HR = 1.14[1.01-1.28)), CRP-colorectal (OR = 1.34 [1.11-1.60]), CRP-lung (HR = 2.03[1.59-2.60]), fibrinogen-lung (OR = 2.56[1.86-3.54]), IL6-lung (OR = 1.41 [1.12-1.78]), CRP-ovarian (OR = 1.41[1.10-1.80]), CRP-prostate (HR = 1.09[1.03-1.15]), CRP-overall (HR = 1.35[1.16-1.57]) and fibrinogen-overall (OR = 1.22[1.07-1.39]). Study quality improvements can be done by better verification of inflammatory status (more than one baseline measurement of one parameter), adjusting for important confounders and ensuring long-term follow-up.}},
  articleno    = {{103177}},
  author       = {{Michels, Nathalie and van Aart, Carola and Morisse, Jens and Mullee, Amy and Huybrechts, Inge}},
  issn         = {{1040-8428}},
  journal      = {{CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY}},
  keywords     = {{Oncology,Geriatrics and Gerontology,Hematology,General Medicine,Cancer,Cytokines,Inflammatory markers,Observational studies,Systematic review,C-REACTIVE PROTEIN,PREDIAGNOSTIC SERUM-LEVELS,OBESITY-RELATED CANCERS,NON-HODGKIN-LYMPHOMA,COLORECTAL-CANCER,OVARIAN-CANCER,BREAST-CANCER,PROSTATE-CANCER,PANCREATIC-CANCER,GASTRIC-CANCER}},
  language     = {{eng}},
  pages        = {{36}},
  title        = {{Chronic inflammation towards cancer incidence : a systematic review and meta-analysis of epidemiological studies}},
  url          = {{http://dx.doi.org/10.1016/j.critrevonc.2020.103177}},
  volume       = {{157}},
  year         = {{2021}},
}

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