Prevalence of cytoplasmic actin mutations in diffuse large B-cell lymphoma and multiple myeloma : a functional assessment based on actin three-dimensional structures
- Author
- Laura Witjes, Marleen Van Troys (UGent) , Bruno Verhasselt (UGent) and Christophe Ampe (UGent)
- Organization
- Abstract
- Mutations in actins have been linked to several developmental diseases. Their occurrence across different cancers has, however, not been investigated. Using the cBioPortal database we show that human actins are infrequently mutated in patient samples of various cancers types. Nevertheless, ranking these studies by mutational frequency suggest that some have a higher percentage of patients with ACTB and ACTG1 mutations. Within studies on hematological cancers, mutations in ACTB and ACTG1 are associated with lymphoid cancers since none have currently been reported in myeloid cancers. Within the different types of lymphoid cancers ACTB mutations are most frequent in diffuse large B-cell lymphoma (DLBCL) and ACTG1 mutations in multiple myeloma. We mapped the ACTB and ACTG1 mutations found in these two cancer types on the 3D-structure of actin showing they are in regions important for actin polymer formation or binding to myosin. The potential effects of the mutations on actin properties imply that mutations in cytoplasmic actins deserve dedicated research in DLBCL and multiple myeloma.
- Keywords
- ACTB, ACTG1, cBioPortal, F-actin, plasma cell myeloma, lymphoid cancer, actin mutations, meta-analysis of patient data, myosin, patient cancer data, BETA-ACTIN, SOMATIC MUTATIONS, MUTANT ACTINS, F-ACTIN, ACTG1, DEAFNESS, EXPRESSION, DFNA20/26, DRIVERS, GENES
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8680773
- MLA
- Witjes, Laura, et al. “Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma : A Functional Assessment Based on Actin Three-Dimensional Structures.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 9, 2020, doi:10.3390/ijms21093093.
- APA
- Witjes, L., Van Troys, M., Verhasselt, B., & Ampe, C. (2020). Prevalence of cytoplasmic actin mutations in diffuse large B-cell lymphoma and multiple myeloma : a functional assessment based on actin three-dimensional structures. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(9). https://doi.org/10.3390/ijms21093093
- Chicago author-date
- Witjes, Laura, Marleen Van Troys, Bruno Verhasselt, and Christophe Ampe. 2020. “Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma : A Functional Assessment Based on Actin Three-Dimensional Structures.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 (9). https://doi.org/10.3390/ijms21093093.
- Chicago author-date (all authors)
- Witjes, Laura, Marleen Van Troys, Bruno Verhasselt, and Christophe Ampe. 2020. “Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma : A Functional Assessment Based on Actin Three-Dimensional Structures.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21 (9). doi:10.3390/ijms21093093.
- Vancouver
- 1.Witjes L, Van Troys M, Verhasselt B, Ampe C. Prevalence of cytoplasmic actin mutations in diffuse large B-cell lymphoma and multiple myeloma : a functional assessment based on actin three-dimensional structures. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(9).
- IEEE
- [1]L. Witjes, M. Van Troys, B. Verhasselt, and C. Ampe, “Prevalence of cytoplasmic actin mutations in diffuse large B-cell lymphoma and multiple myeloma : a functional assessment based on actin three-dimensional structures,” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 9, 2020.
@article{8680773,
abstract = {{Mutations in actins have been linked to several developmental diseases. Their occurrence across different cancers has, however, not been investigated. Using the cBioPortal database we show that human actins are infrequently mutated in patient samples of various cancers types. Nevertheless, ranking these studies by mutational frequency suggest that some have a higher percentage of patients with ACTB and ACTG1 mutations. Within studies on hematological cancers, mutations in ACTB and ACTG1 are associated with lymphoid cancers since none have currently been reported in myeloid cancers. Within the different types of lymphoid cancers ACTB mutations are most frequent in diffuse large B-cell lymphoma (DLBCL) and ACTG1 mutations in multiple myeloma. We mapped the ACTB and ACTG1 mutations found in these two cancer types on the 3D-structure of actin showing they are in regions important for actin polymer formation or binding to myosin. The potential effects of the mutations on actin properties imply that mutations in cytoplasmic actins deserve dedicated research in DLBCL and multiple myeloma.}},
articleno = {{3093}},
author = {{Witjes, Laura and Van Troys, Marleen and Verhasselt, Bruno and Ampe, Christophe}},
issn = {{1422-0067}},
journal = {{INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}},
keywords = {{ACTB,ACTG1,cBioPortal,F-actin,plasma cell myeloma,lymphoid cancer,actin mutations,meta-analysis of patient data,myosin,patient cancer data,BETA-ACTIN,SOMATIC MUTATIONS,MUTANT ACTINS,F-ACTIN,ACTG1,DEAFNESS,EXPRESSION,DFNA20/26,DRIVERS,GENES}},
language = {{eng}},
number = {{9}},
pages = {{16}},
title = {{Prevalence of cytoplasmic actin mutations in diffuse large B-cell lymphoma and multiple myeloma : a functional assessment based on actin three-dimensional structures}},
url = {{http://doi.org/10.3390/ijms21093093}},
volume = {{21}},
year = {{2020}},
}
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