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Synbiotic effect of Bifidobacterium lactis CNCM I-3446 and bovine milk-derived oligosaccharides on infant gut microbiota

(2020) NUTRIENTS. 12(8).
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Abstract
Background: This study evaluated the impact ofBifidobacterium animalisssp.lactisCNCM I-3446, Bovine Milk-derived OligoSaccharides (BMOS) and their combination on infant gut microbiota in vitro. In addition, a novel strategy consisting of preculturingB. lactiswith BMOS to further enhance their potential synbiotic effects was assessed. Method: Short-term fecal batch fermentations (48 h) were used to assess the microbial composition and activity modulated by BMOS alone,B. lactisgrown on BMOS or dextrose alone, or their combinations on different three-month-old infant microbiota. Results: BMOS alone significantly induced acetate and lactate production (leading to pH decrease) and stimulated bifidobacterial growth in 10 donors. A further in-depth study on two different donors provedB. lactisability to colonize the infant microbiota, regardless of the competitiveness of the environment. BMOS further enhanced this engraftment, suggesting a strong synbiotic effect. This was also observed at the microbiota activity level, especially in a donor containing low initial levels of bifidobacteria. In this donor, preculturingB. lactiswith BMOS strengthened further the early modulation of microbiota activity observed after 6 h. Conclusion: This study demonstrated the strong synbiotic effect of BMOS andB. lactison the infant gut microbiota, and suggests a strategy to improve its effectiveness in an otherwise low-Bifidobacteriummicrobiota.
Keywords
infant gut microbiota, Bifidobacterium animalisssp, lactis, BMOS, in vitro fermentation, probiotic, prebiotic, dysbiosis, preculturing, synbiotic, oligosaccharides, INTERNATIONAL SCIENTIFIC ASSOCIATION, CHAIN FATTY-ACIDS, BIFIDOBACTERIUM-LACTIS, CONSENSUS STATEMENT, PREBIOTICS, PROBIOTICS, FORMULA, HEALTH, FERMENTATION, IMPACT

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Citation

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MLA
Marsaux, Benoit, et al. “Synbiotic Effect of Bifidobacterium Lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota.” NUTRIENTS, vol. 12, no. 8, 2020, doi:10.3390/nu12082268.
APA
Marsaux, B., Van den Abbeele, P., Ghyselinck, J., Prioult, G., Marzorati, M., & Bogicevic, B. (2020). Synbiotic effect of Bifidobacterium lactis CNCM I-3446 and bovine milk-derived oligosaccharides on infant gut microbiota. NUTRIENTS, 12(8). https://doi.org/10.3390/nu12082268
Chicago author-date
Marsaux, Benoit, Pieter Van den Abbeele, Jonas Ghyselinck, Guenolee Prioult, Massimo Marzorati, and Biljana Bogicevic. 2020. “Synbiotic Effect of Bifidobacterium Lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota.” NUTRIENTS 12 (8). https://doi.org/10.3390/nu12082268.
Chicago author-date (all authors)
Marsaux, Benoit, Pieter Van den Abbeele, Jonas Ghyselinck, Guenolee Prioult, Massimo Marzorati, and Biljana Bogicevic. 2020. “Synbiotic Effect of Bifidobacterium Lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota.” NUTRIENTS 12 (8). doi:10.3390/nu12082268.
Vancouver
1.
Marsaux B, Van den Abbeele P, Ghyselinck J, Prioult G, Marzorati M, Bogicevic B. Synbiotic effect of Bifidobacterium lactis CNCM I-3446 and bovine milk-derived oligosaccharides on infant gut microbiota. NUTRIENTS. 2020;12(8).
IEEE
[1]
B. Marsaux, P. Van den Abbeele, J. Ghyselinck, G. Prioult, M. Marzorati, and B. Bogicevic, “Synbiotic effect of Bifidobacterium lactis CNCM I-3446 and bovine milk-derived oligosaccharides on infant gut microbiota,” NUTRIENTS, vol. 12, no. 8, 2020.
@article{8680566,
  abstract     = {{Background: This study evaluated the impact ofBifidobacterium animalisssp.lactisCNCM I-3446, Bovine Milk-derived OligoSaccharides (BMOS) and their combination on infant gut microbiota in vitro. In addition, a novel strategy consisting of preculturingB. lactiswith BMOS to further enhance their potential synbiotic effects was assessed. Method: Short-term fecal batch fermentations (48 h) were used to assess the microbial composition and activity modulated by BMOS alone,B. lactisgrown on BMOS or dextrose alone, or their combinations on different three-month-old infant microbiota. Results: BMOS alone significantly induced acetate and lactate production (leading to pH decrease) and stimulated bifidobacterial growth in 10 donors. A further in-depth study on two different donors provedB. lactisability to colonize the infant microbiota, regardless of the competitiveness of the environment. BMOS further enhanced this engraftment, suggesting a strong synbiotic effect. This was also observed at the microbiota activity level, especially in a donor containing low initial levels of bifidobacteria. In this donor, preculturingB. lactiswith BMOS strengthened further the early modulation of microbiota activity observed after 6 h. Conclusion: This study demonstrated the strong synbiotic effect of BMOS andB. lactison the infant gut microbiota, and suggests a strategy to improve its effectiveness in an otherwise low-Bifidobacteriummicrobiota.}},
  articleno    = {{2268}},
  author       = {{Marsaux, Benoit and Van den Abbeele, Pieter and Ghyselinck, Jonas and Prioult, Guenolee and Marzorati, Massimo and Bogicevic, Biljana}},
  issn         = {{2072-6643}},
  journal      = {{NUTRIENTS}},
  keywords     = {{infant gut microbiota,Bifidobacterium animalisssp,lactis,BMOS,in vitro fermentation,probiotic,prebiotic,dysbiosis,preculturing,synbiotic,oligosaccharides,INTERNATIONAL SCIENTIFIC ASSOCIATION,CHAIN FATTY-ACIDS,BIFIDOBACTERIUM-LACTIS,CONSENSUS STATEMENT,PREBIOTICS,PROBIOTICS,FORMULA,HEALTH,FERMENTATION,IMPACT}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{21}},
  title        = {{Synbiotic effect of Bifidobacterium lactis CNCM I-3446 and bovine milk-derived oligosaccharides on infant gut microbiota}},
  url          = {{http://dx.doi.org/10.3390/nu12082268}},
  volume       = {{12}},
  year         = {{2020}},
}

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