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Recent developments in electrochemical detection of illicit drugs in diverse matrices

Esther De Rycke (UGent) , Christophe Stove (UGent) , Peter Dubruel (UGent) , Sarah De Saeger (UGent) and Natalia Beloglazova (UGent)
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Organization
Project
  • microMole (Sewage monitoring system for tracking synthetic drug laboratories)
Abstract
Drug abuse is a global problem, requiring an interdisciplinary approach. Discovery, production, trafficking, and consumption of illicit drugs have been constantly growing, leading to heavy consequences for environment, human health, and society in general. Therefore, an urgent need for rapid, sensitive, portable and easy-to-operate detection methods for numerous drugs of interest in diverse matrices, from police samples, biological fluids and hair to sewage water has risen. Electrochemical sensors are promising alternatives to chromatography and spectrometry. Last decades, electrochemical sensing of illegal drugs has experienced a very significant growth, driven by improved transducers and signal amplifiers helping to improve the sensitivity and selectivity. The present review summarizes recent advances (last 10 years) in electrochemical detection of the most prevailing illicit drugs (such as cocaine, heroin, and (meth)amphetamine), their precursors and derivatives in different matrices. Various electrochemical sensors making use of different transducers with their (dis)advantages were discussed, and their sensitivity and applicability were critically compared. In those cases where natural or synthetic recognition elements were included in the sensing system to increase specificity, selected recognition elements, their immobilization, working conditions, and analytical performance were discussed. Finally, an outlook is presented with suggestions and recommendations for future developments.
Keywords
Biotechnology, Biophysics, Electrochemistry, Biomedical Engineering, General Medicine, Illicit drugs, Electrochemical sensors, Recognition elements, FLOW-INJECTION ANALYSIS, LABEL-FREE DETECTION, VOLTAMMETRIC DETERMINATION, AMPEROMETRIC DETECTION, STREET SAMPLES, CAPACITIVE BIOSENSOR, CARBON ELECTRODES, COCAINE USERS, IMMOBILIZATION, METHAMPHETAMINE

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Citation

Please use this url to cite or link to this publication:

MLA
De Rycke, Esther, et al. “Recent Developments in Electrochemical Detection of Illicit Drugs in Diverse Matrices.” BIOSENSORS & BIOELECTRONICS, vol. 169, 2020, doi:10.1016/j.bios.2020.112579.
APA
De Rycke, E., Stove, C., Dubruel, P., De Saeger, S., & Beloglazova, N. (2020). Recent developments in electrochemical detection of illicit drugs in diverse matrices. BIOSENSORS & BIOELECTRONICS, 169. https://doi.org/10.1016/j.bios.2020.112579
Chicago author-date
De Rycke, Esther, Christophe Stove, Peter Dubruel, Sarah De Saeger, and Natalia Beloglazova. 2020. “Recent Developments in Electrochemical Detection of Illicit Drugs in Diverse Matrices.” BIOSENSORS & BIOELECTRONICS 169. https://doi.org/10.1016/j.bios.2020.112579.
Chicago author-date (all authors)
De Rycke, Esther, Christophe Stove, Peter Dubruel, Sarah De Saeger, and Natalia Beloglazova. 2020. “Recent Developments in Electrochemical Detection of Illicit Drugs in Diverse Matrices.” BIOSENSORS & BIOELECTRONICS 169. doi:10.1016/j.bios.2020.112579.
Vancouver
1.
De Rycke E, Stove C, Dubruel P, De Saeger S, Beloglazova N. Recent developments in electrochemical detection of illicit drugs in diverse matrices. BIOSENSORS & BIOELECTRONICS. 2020;169.
IEEE
[1]
E. De Rycke, C. Stove, P. Dubruel, S. De Saeger, and N. Beloglazova, “Recent developments in electrochemical detection of illicit drugs in diverse matrices,” BIOSENSORS & BIOELECTRONICS, vol. 169, 2020.
@article{8680153,
  abstract     = {{Drug abuse is a global problem, requiring an interdisciplinary approach. Discovery, production, trafficking, and consumption of illicit drugs have been constantly growing, leading to heavy consequences for environment, human health, and society in general. Therefore, an urgent need for rapid, sensitive, portable and easy-to-operate detection methods for numerous drugs of interest in diverse matrices, from police samples, biological fluids and hair to sewage water has risen. Electrochemical sensors are promising alternatives to chromatography and spectrometry. Last decades, electrochemical sensing of illegal drugs has experienced a very significant growth, driven by improved transducers and signal amplifiers helping to improve the sensitivity and selectivity. The present review summarizes recent advances (last 10 years) in electrochemical detection of the most prevailing illicit drugs (such as cocaine, heroin, and (meth)amphetamine), their precursors and derivatives in different matrices. Various electrochemical sensors making use of different transducers with their (dis)advantages were discussed, and their sensitivity and applicability were critically compared. In those cases where natural or synthetic recognition elements were included in the sensing system to increase specificity, selected recognition elements, their immobilization, working conditions, and analytical performance were discussed. Finally, an outlook is presented with suggestions and recommendations for future developments.}},
  articleno    = {{112579}},
  author       = {{De Rycke, Esther and Stove, Christophe and Dubruel, Peter and De Saeger, Sarah and Beloglazova, Natalia}},
  issn         = {{0956-5663}},
  journal      = {{BIOSENSORS & BIOELECTRONICS}},
  keywords     = {{Biotechnology,Biophysics,Electrochemistry,Biomedical Engineering,General Medicine,Illicit drugs,Electrochemical sensors,Recognition elements,FLOW-INJECTION ANALYSIS,LABEL-FREE DETECTION,VOLTAMMETRIC DETERMINATION,AMPEROMETRIC DETECTION,STREET SAMPLES,CAPACITIVE BIOSENSOR,CARBON ELECTRODES,COCAINE USERS,IMMOBILIZATION,METHAMPHETAMINE}},
  language     = {{eng}},
  pages        = {{13}},
  title        = {{Recent developments in electrochemical detection of illicit drugs in diverse matrices}},
  url          = {{http://dx.doi.org/10.1016/j.bios.2020.112579}},
  volume       = {{169}},
  year         = {{2020}},
}

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