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Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic : perspective from a European country

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Abstract
Starting from historic reflections, the current SARS-CoV-2 induced COVID-19 pandemic is examined from various perspectives, in terms of what it implies for the implementation of non-pharmaceutical interventions, the modeling and monitoring of the epidemic, the development of early-warning systems, the study of mortality, prevalence estimation, diagnostic and serological testing, vaccine development, and ultimately clinical trials. Emphasis is placed on how the pandemic had led to unprecedented speed in methodological and clinical development, the pitfalls thereof, but also the opportunities that it engenders for national and international collaboration, and how it has simplified and sped up procedures. We also study the impact of the pandemic on clinical trials in other indications. We note that it has placed biostatistics, epidemiology, virology, infectiology, and vaccinology, and related fields in the spotlight in an unprecedented way, implying great opportunities, but also the need to communicate effectively, often amidst controversy.
Keywords
SARS-CoV-2, Antiviral therapy, Diagnostic testing, Infection fatality rate, Mortality, Non-pharmaceutical intervention, Nowcasting, Prevalence, Mathematical epidemiology, Mathematical modeling, Vaccine development, Pragmatic trials, Factorial designs, Platform trials, Data sharing, REGRESSION-MODELS, CORONAVIRUS, IMPACT, TRANSMISSION, PREVALENCE, INFLUENZA, IMMUNITY, ERRORS

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MLA
Molenberghs, Geert, et al. “Infectious Diseases Epidemiology, Quantitative Methodology, and Clinical Research in the Midst of the COVID-19 Pandemic : Perspective from a European Country.” CONTEMPORARY CLINICAL TRIALS, vol. 99, 2020, doi:10.1016/j.cct.2020.106189.
APA
Molenberghs, G., Buyse, M., Abrams, S., Hens, N., Beutels, P., Faes, C., … Hulstaert, F. (2020). Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic : perspective from a European country. CONTEMPORARY CLINICAL TRIALS, 99. https://doi.org/10.1016/j.cct.2020.106189
Chicago author-date
Molenberghs, Geert, Marc Buyse, Steven Abrams, Niel Hens, Philippe Beutels, Christel Faes, Geert Verbeke, et al. 2020. “Infectious Diseases Epidemiology, Quantitative Methodology, and Clinical Research in the Midst of the COVID-19 Pandemic : Perspective from a European Country.” CONTEMPORARY CLINICAL TRIALS 99. https://doi.org/10.1016/j.cct.2020.106189.
Chicago author-date (all authors)
Molenberghs, Geert, Marc Buyse, Steven Abrams, Niel Hens, Philippe Beutels, Christel Faes, Geert Verbeke, Pierre Van Damme, Herman Goossens, Thomas Neyens, Sereina Herzog, Heidi Theeten, Koen Pepermans, Ariel Alonso Abad, Ingrid Van Keilegom, Niko Speybroeck, Catherine Legrand, Stefanie De Buyser, and Frank Hulstaert. 2020. “Infectious Diseases Epidemiology, Quantitative Methodology, and Clinical Research in the Midst of the COVID-19 Pandemic : Perspective from a European Country.” CONTEMPORARY CLINICAL TRIALS 99. doi:10.1016/j.cct.2020.106189.
Vancouver
1.
Molenberghs G, Buyse M, Abrams S, Hens N, Beutels P, Faes C, et al. Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic : perspective from a European country. CONTEMPORARY CLINICAL TRIALS. 2020;99.
IEEE
[1]
G. Molenberghs et al., “Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic : perspective from a European country,” CONTEMPORARY CLINICAL TRIALS, vol. 99, 2020.
@article{8679189,
  abstract     = {Starting from historic reflections, the current SARS-CoV-2 induced COVID-19 pandemic is examined from various perspectives, in terms of what it implies for the implementation of non-pharmaceutical interventions, the modeling and monitoring of the epidemic, the development of early-warning systems, the study of mortality, prevalence estimation, diagnostic and serological testing, vaccine development, and ultimately clinical trials. Emphasis is placed on how the pandemic had led to unprecedented speed in methodological and clinical development, the pitfalls thereof, but also the opportunities that it engenders for national and international collaboration, and how it has simplified and sped up procedures. We also study the impact of the pandemic on clinical trials in other indications. We note that it has placed biostatistics, epidemiology, virology, infectiology, and vaccinology, and related fields in the spotlight in an unprecedented way, implying great opportunities, but also the need to communicate effectively, often amidst controversy.},
  articleno    = {106189},
  author       = {Molenberghs, Geert and Buyse, Marc and Abrams, Steven and Hens, Niel and Beutels, Philippe and Faes, Christel and Verbeke, Geert and Van Damme, Pierre and Goossens, Herman and Neyens, Thomas and Herzog, Sereina and Theeten, Heidi and Pepermans, Koen and Abad, Ariel Alonso and Van Keilegom, Ingrid and Speybroeck, Niko and Legrand, Catherine and De Buyser, Stefanie and Hulstaert, Frank},
  issn         = {1551-7144},
  journal      = {CONTEMPORARY CLINICAL TRIALS},
  keywords     = {SARS-CoV-2,Antiviral therapy,Diagnostic testing,Infection fatality rate,Mortality,Non-pharmaceutical intervention,Nowcasting,Prevalence,Mathematical epidemiology,Mathematical modeling,Vaccine development,Pragmatic trials,Factorial designs,Platform trials,Data sharing,REGRESSION-MODELS,CORONAVIRUS,IMPACT,TRANSMISSION,PREVALENCE,INFLUENZA,IMMUNITY,ERRORS},
  language     = {eng},
  pages        = {17},
  title        = {Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic : perspective from a European country},
  url          = {http://dx.doi.org/10.1016/j.cct.2020.106189},
  volume       = {99},
  year         = {2020},
}

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