@article{8678753,
  abstract     = {{The link between quorum sensing in Vibrio campbellii and its virulence towards tiger grouper (Epinephelus fuscoguttatus) was investigated using V. campbellii wild type and quorum-sensing mutants with inactive quorum sensing or constitutively maximal quorum-sensing activity, and signal molecule synthase mutants. The results showed that wild-type V. campbellii is pathogenic to grouper larvae, causing more than 50% mortality after 4 days of challenge. Furthermore, the mortality of larvae challenged with the mutant with maximally active quorum sensing was significantly higher than that of larvae challenged with the wild type, whereas a higher survival was observed in the larvae challenged to the mutant with a completely inactive quorum-sensing system. Grouper larvae challenged with either the signal molecule synthase triple mutant, the harveyi autoinducer-1 (HAI-1) synthase mutant and the autoinducer-2 (AI-2) synthase mutant showed higher survival than larvae challenged with the wild type. In contrast, larvae challenged with the cholerae autoinducer-1 (CAI-1) synthase mutant showed high mortality. This indicates that HAI-1 and AI-2, but not CAI-1, are required for full virulence of V. campbellii towards grouper larvae. Our data suggest that quorum-sensing inhibition could be an effective strategy to control V. campbellii infections in tiger grouper.}},
  author       = {{Noor, Noorashikin Md. and Defoirdt, Tom and Alipiah, Norfarrah and Karim, Murni and Daud, Hassan and Natrah, Ikhsan}},
  issn         = {{0140-7775}},
  journal      = {{JOURNAL OF FISH DISEASES}},
  keywords     = {{quorum sensing,signalling,vibriosis,virulence,HARVEYI,SYSTEMS,SHRIMP,ANGUILLARUM,INFECTION,DISEASE,IDENTIFICATION,AQUACULTURE,PROTECTION,REGULATOR}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{489--495}},
  title        = {{Quorum sensing is required for full virulence of Vibrio campbellii towards tiger grouper (Epinephelus fuscoguttatus) larvae}},
  url          = {{http://doi.org/10.1111/jfd.12946}},
  volume       = {{42}},
  year         = {{2019}},
}

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