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Ethanol:propionate ratio drives product selectivity in odd-chain elongation with Clostridium kluyveri and mixed communities

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Abstract
Microbial production of valerate, a five-carbon carboxylate, can occur from propionate and ethanol through a process called odd-chain elongation. The generation of even-chain compounds in this process lowers product selectivity, forming a key challenge. This study investigated factors determining product selectivity during odd-chain elongation in an odd-chain elongating mixed community and the pure culture Clostridium kluyveri DSM555. Incubations at different ratios of ethanol:propionate showed that increasing ratios (from 0.5 to 7) lowered product specificity, as evidenced by a decrease in the odd:even product ratio from 5.5 to 1.5 for C. kluyveri and from 15 to 0.8 for the mixed community. The consistency of these observations with literature data suggests that control of ethanol:propionate ratio offers a robust tool for process control in odd-chain elongation, while the flexible metabolism can also have implications for efficient use of ethanol during even-chain elongation processes.
Keywords
Renewable Energy, Sustainability and the Environment, Environmental Engineering, Waste Management and Disposal, Bioengineering, General Medicine, Bioproduction, Chain elongation, Valerate, Clostridium kluyveri, CAPROIC ACID

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MLA
Candry, Pieter, et al. “Ethanol:Propionate Ratio Drives Product Selectivity in Odd-Chain Elongation with Clostridium Kluyveri and Mixed Communities.” BIORESOURCE TECHNOLOGY, vol. 313, 2020, doi:10.1016/j.biortech.2020.123651.
APA
Candry, P., Ulčar, B., Petrognani, C., Rabaey, K., & Ganigué, R. (2020). Ethanol:propionate ratio drives product selectivity in odd-chain elongation with Clostridium kluyveri and mixed communities. BIORESOURCE TECHNOLOGY, 313. https://doi.org/10.1016/j.biortech.2020.123651
Chicago author-date
Candry, Pieter, Barbara Ulčar, Camille Petrognani, Korneel Rabaey, and Ramon Ganigué. 2020. “Ethanol:Propionate Ratio Drives Product Selectivity in Odd-Chain Elongation with Clostridium Kluyveri and Mixed Communities.” BIORESOURCE TECHNOLOGY 313. https://doi.org/10.1016/j.biortech.2020.123651.
Chicago author-date (all authors)
Candry, Pieter, Barbara Ulčar, Camille Petrognani, Korneel Rabaey, and Ramon Ganigué. 2020. “Ethanol:Propionate Ratio Drives Product Selectivity in Odd-Chain Elongation with Clostridium Kluyveri and Mixed Communities.” BIORESOURCE TECHNOLOGY 313. doi:10.1016/j.biortech.2020.123651.
Vancouver
1.
Candry P, Ulčar B, Petrognani C, Rabaey K, Ganigué R. Ethanol:propionate ratio drives product selectivity in odd-chain elongation with Clostridium kluyveri and mixed communities. BIORESOURCE TECHNOLOGY. 2020;313.
IEEE
[1]
P. Candry, B. Ulčar, C. Petrognani, K. Rabaey, and R. Ganigué, “Ethanol:propionate ratio drives product selectivity in odd-chain elongation with Clostridium kluyveri and mixed communities,” BIORESOURCE TECHNOLOGY, vol. 313, 2020.
@article{8678612,
  abstract     = {{Microbial production of valerate, a five-carbon carboxylate, can occur from propionate and ethanol through a process called odd-chain elongation. The generation of even-chain compounds in this process lowers product selectivity, forming a key challenge. This study investigated factors determining product selectivity during odd-chain elongation in an odd-chain elongating mixed community and the pure culture Clostridium kluyveri DSM555. Incubations at different ratios of ethanol:propionate showed that increasing ratios (from 0.5 to 7) lowered product specificity, as evidenced by a decrease in the odd:even product ratio from 5.5 to 1.5 for C. kluyveri and from 15 to 0.8 for the mixed community. The consistency of these observations with literature data suggests that control of ethanol:propionate ratio offers a robust tool for process control in odd-chain elongation, while the flexible metabolism can also have implications for efficient use of ethanol during even-chain elongation processes.}},
  articleno    = {{123651}},
  author       = {{Candry, Pieter and Ulčar, Barbara and Petrognani, Camille and Rabaey, Korneel and Ganigué, Ramon}},
  issn         = {{0960-8524}},
  journal      = {{BIORESOURCE TECHNOLOGY}},
  keywords     = {{Renewable Energy,Sustainability and the Environment,Environmental Engineering,Waste Management and Disposal,Bioengineering,General Medicine,Bioproduction,Chain elongation,Valerate,Clostridium kluyveri,CAPROIC ACID}},
  language     = {{eng}},
  pages        = {{5}},
  title        = {{Ethanol:propionate ratio drives product selectivity in odd-chain elongation with Clostridium kluyveri and mixed communities}},
  url          = {{http://dx.doi.org/10.1016/j.biortech.2020.123651}},
  volume       = {{313}},
  year         = {{2020}},
}

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