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Assessment of insecticidal effects and selectivity ofCAPA-PKpeptide analogues against the peach-potato aphid and four beneficial insects following topical exposure

(2020) PEST MANAGEMENT SCIENCE. 76(10). p.3451-3458
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Abstract
BACKGROUND Insect Capability neuropeptides (CAP2b/CAPA-PKs) play a critical role in modulating different physiologies and behavior in insects. In a previous proof-of-concept study, the CAP2b analogues 1895 (2Abf-Suc-FGPRLamide) and 2129 (2Abf-Suc-ATPRIamide) were reported to reduce aphid fitness when administered by injection. In the current study, the insecticidal efficacy of 1895 and 2129 on the peach potato aphidMyzus persicaewas analyzed by topical application, simulating a spray application scenario in the field. Additionally, the selectivity of the tested analogues was evaluated against a selection of beneficial insects, namely three natural enemies (Adalia bipunctata,Chrysoperla carneaandNasonia vitripennis) and a pollinator (Bombus terrestris). RESULTS Within 3-5 days post topical exposure of aphids to 1895, higher mortality (33%) was observed, as was the case for the treatment with 2129 (17%) and the mixture of 1895 + 2129 (47%) compared to the control (3%). 1895 and the mix 1895 + 2129 showed the strongest and comparable insecticidal effects. Additionally, surviving aphids treated with 1895 showed a reduction in total lifetime reproduction (GRR) of 30%, 19% with 2129 and 39% with the mix 1895 + 2129. Of interest from a biosafety perspective is that by using the same delivery method and dose, no significant effects on survival, weight increase and food intake was observed for the representative natural enemies and the pollinator. CONCLUSION This study highlights the potential of exploiting CAP2b analogues such as 1895 (core structure FGPRL) as aphicides. Additionally, the CAP2b analogues used in this study were selective as they showed no effects when applied on four representative beneficial insects.
Keywords
RED FLOUR BEETLE, TRIBOLIUM-CASTANEUM, DROSOPHILA, NEUROPEPTIDES, DESICCATION, RECEPTORS, AGONISTS, CAP(2B), aphicide, CAPA, topical application, pest control, biosafety

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MLA
Gui, Shunhua, et al. “Assessment of Insecticidal Effects and Selectivity OfCAPA-PKpeptide Analogues against the Peach-Potato Aphid and Four Beneficial Insects Following Topical Exposure.” PEST MANAGEMENT SCIENCE, vol. 76, no. 10, 2020, pp. 3451–58, doi:10.1002/ps.5971.
APA
Gui, S., Taning, N. T. C., De Schutter, K., Yang, Q., Chen, P., Hamshou, M., … Smagghe, G. (2020). Assessment of insecticidal effects and selectivity ofCAPA-PKpeptide analogues against the peach-potato aphid and four beneficial insects following topical exposure. PEST MANAGEMENT SCIENCE, 76(10), 3451–3458. https://doi.org/10.1002/ps.5971
Chicago author-date
Gui, Shunhua, Nji Tizi Clauvis Taning, Kristof De Schutter, Qun Yang, Pengyu Chen, Mohamad Hamshou, Ronald J. Nachman, et al. 2020. “Assessment of Insecticidal Effects and Selectivity OfCAPA-PKpeptide Analogues against the Peach-Potato Aphid and Four Beneficial Insects Following Topical Exposure.” PEST MANAGEMENT SCIENCE 76 (10): 3451–58. https://doi.org/10.1002/ps.5971.
Chicago author-date (all authors)
Gui, Shunhua, Nji Tizi Clauvis Taning, Kristof De Schutter, Qun Yang, Pengyu Chen, Mohamad Hamshou, Ronald J. Nachman, Aniruddha A. Pandit, Julian A. T. Dow, Shireen Davies, and Guy Smagghe. 2020. “Assessment of Insecticidal Effects and Selectivity OfCAPA-PKpeptide Analogues against the Peach-Potato Aphid and Four Beneficial Insects Following Topical Exposure.” PEST MANAGEMENT SCIENCE 76 (10): 3451–3458. doi:10.1002/ps.5971.
Vancouver
1.
Gui S, Taning NTC, De Schutter K, Yang Q, Chen P, Hamshou M, et al. Assessment of insecticidal effects and selectivity ofCAPA-PKpeptide analogues against the peach-potato aphid and four beneficial insects following topical exposure. PEST MANAGEMENT SCIENCE. 2020;76(10):3451–8.
IEEE
[1]
S. Gui et al., “Assessment of insecticidal effects and selectivity ofCAPA-PKpeptide analogues against the peach-potato aphid and four beneficial insects following topical exposure,” PEST MANAGEMENT SCIENCE, vol. 76, no. 10, pp. 3451–3458, 2020.
@article{8678538,
  abstract     = {{BACKGROUND Insect Capability neuropeptides (CAP2b/CAPA-PKs) play a critical role in modulating different physiologies and behavior in insects. In a previous proof-of-concept study, the CAP2b analogues 1895 (2Abf-Suc-FGPRLamide) and 2129 (2Abf-Suc-ATPRIamide) were reported to reduce aphid fitness when administered by injection. In the current study, the insecticidal efficacy of 1895 and 2129 on the peach potato aphidMyzus persicaewas analyzed by topical application, simulating a spray application scenario in the field. Additionally, the selectivity of the tested analogues was evaluated against a selection of beneficial insects, namely three natural enemies (Adalia bipunctata,Chrysoperla carneaandNasonia vitripennis) and a pollinator (Bombus terrestris). RESULTS Within 3-5 days post topical exposure of aphids to 1895, higher mortality (33%) was observed, as was the case for the treatment with 2129 (17%) and the mixture of 1895 + 2129 (47%) compared to the control (3%). 1895 and the mix 1895 + 2129 showed the strongest and comparable insecticidal effects. Additionally, surviving aphids treated with 1895 showed a reduction in total lifetime reproduction (GRR) of 30%, 19% with 2129 and 39% with the mix 1895 + 2129. Of interest from a biosafety perspective is that by using the same delivery method and dose, no significant effects on survival, weight increase and food intake was observed for the representative natural enemies and the pollinator. CONCLUSION This study highlights the potential of exploiting CAP2b analogues such as 1895 (core structure FGPRL) as aphicides. Additionally, the CAP2b analogues used in this study were selective as they showed no effects when applied on four representative beneficial insects.}},
  author       = {{Gui, Shunhua and Taning, Nji Tizi Clauvis and De Schutter, Kristof and Yang, Qun and Chen, Pengyu and Hamshou, Mohamad and Nachman, Ronald J. and Pandit, Aniruddha A. and Dow, Julian A. T. and Davies, Shireen and Smagghe, Guy}},
  issn         = {{1526-498X}},
  journal      = {{PEST MANAGEMENT SCIENCE}},
  keywords     = {{RED FLOUR BEETLE,TRIBOLIUM-CASTANEUM,DROSOPHILA,NEUROPEPTIDES,DESICCATION,RECEPTORS,AGONISTS,CAP(2B),aphicide,CAPA,topical application,pest control,biosafety}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{3451--3458}},
  title        = {{Assessment of insecticidal effects and selectivity ofCAPA-PKpeptide analogues against the peach-potato aphid and four beneficial insects following topical exposure}},
  url          = {{http://dx.doi.org/10.1002/ps.5971}},
  volume       = {{76}},
  year         = {{2020}},
}

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