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Splenic hematopoietic and stromal cells in cancer progression

Jonas Steenbrugge (UGent) , Emiel De Jaeghere (UGent) , Evelyne Meyer (UGent) , Hannelore Denys (UGent) and Olivier De Wever (UGent)
(2020) CANCER RESEARCH. 81(1). p.27-34
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Abstract
Tumor-derived secretory factors orchestrate splenic hematopoietic and stromal cells to fuel metastasis. The spleen acts as a reservoir site for hematopoietic stem and progenitor cells, which are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid cells. Splenic erythroid progenitor cells and mesenchymal stromal cells contribute directly and indirectly to both tumor immune escape and the metastatic cascade. Animal models provide valuable mechanistic insights, but their translation to a clinical setting highlights specific challenges and open issues. In this review, we envision the exploitation of the spleen as a source for novel biomarkers and therapeutic approaches.
Keywords
Cancer Research, Oncology, REGULATORY T-CELLS, SUPPRESSOR-CELLS, BREAST-CANCER, EXTRAMEDULLARY HEMATOPOIESIS, SEVERE LYMPHOPENIA, POOR-PROGNOSIS, BONE-MARROW, SPLEEN, RADIATION, IMMUNITY

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MLA
Steenbrugge, Jonas, et al. “Splenic Hematopoietic and Stromal Cells in Cancer Progression.” CANCER RESEARCH, vol. 81, no. 1, 2020, pp. 27–34, doi:10.1158/0008-5472.can-20-2339.
APA
Steenbrugge, J., De Jaeghere, E., Meyer, E., Denys, H., & De Wever, O. (2020). Splenic hematopoietic and stromal cells in cancer progression. CANCER RESEARCH, 81(1), 27–34. https://doi.org/10.1158/0008-5472.can-20-2339
Chicago author-date
Steenbrugge, Jonas, Emiel De Jaeghere, Evelyne Meyer, Hannelore Denys, and Olivier De Wever. 2020. “Splenic Hematopoietic and Stromal Cells in Cancer Progression.” CANCER RESEARCH 81 (1): 27–34. https://doi.org/10.1158/0008-5472.can-20-2339.
Chicago author-date (all authors)
Steenbrugge, Jonas, Emiel De Jaeghere, Evelyne Meyer, Hannelore Denys, and Olivier De Wever. 2020. “Splenic Hematopoietic and Stromal Cells in Cancer Progression.” CANCER RESEARCH 81 (1): 27–34. doi:10.1158/0008-5472.can-20-2339.
Vancouver
1.
Steenbrugge J, De Jaeghere E, Meyer E, Denys H, De Wever O. Splenic hematopoietic and stromal cells in cancer progression. CANCER RESEARCH. 2020;81(1):27–34.
IEEE
[1]
J. Steenbrugge, E. De Jaeghere, E. Meyer, H. Denys, and O. De Wever, “Splenic hematopoietic and stromal cells in cancer progression,” CANCER RESEARCH, vol. 81, no. 1, pp. 27–34, 2020.
@article{8677982,
  abstract     = {{Tumor-derived secretory factors orchestrate splenic hematopoietic and stromal cells to fuel metastasis. The spleen acts as a reservoir site for hematopoietic stem and progenitor cells, which are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid cells. Splenic erythroid progenitor cells and mesenchymal stromal cells contribute directly and indirectly to both tumor immune escape and the metastatic cascade. Animal models provide valuable mechanistic insights, but their translation to a clinical setting highlights specific challenges and open issues. In this review, we envision the exploitation of the spleen as a source for novel biomarkers and therapeutic approaches.}},
  author       = {{Steenbrugge, Jonas and De Jaeghere, Emiel and Meyer, Evelyne and Denys, Hannelore and De Wever, Olivier}},
  issn         = {{0008-5472}},
  journal      = {{CANCER RESEARCH}},
  keywords     = {{Cancer Research,Oncology,REGULATORY T-CELLS,SUPPRESSOR-CELLS,BREAST-CANCER,EXTRAMEDULLARY HEMATOPOIESIS,SEVERE LYMPHOPENIA,POOR-PROGNOSIS,BONE-MARROW,SPLEEN,RADIATION,IMMUNITY}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{27--34}},
  title        = {{Splenic hematopoietic and stromal cells in cancer progression}},
  url          = {{http://dx.doi.org/10.1158/0008-5472.can-20-2339}},
  volume       = {{81}},
  year         = {{2020}},
}

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