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Dynamic causal modelling of the reduced habituation to painful stimuli in migraine : an EEG study

Iege Bassez, Frederik Van de Steen (UGent) , Katia Ricci, Eleonora Vecchio, Eleonora Gentile, Daniele Marinazzo (UGent) and Marina de Tommaso
(2020) BRAIN SCIENCES. 10(10).
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Abstract
A consistent finding in migraine is reduced cortical habituation to repetitive sensory stimuli. This study investigated brain dynamics underlying the atypical habituation to painful stimuli in interictal migraine. We investigated modulations in effective connectivity between the sources of laser evoked potentials (LEPs) from a first to final block of trigeminal LEPs using dynamic causal modelling (DCM) in a group of 23 migraine patients and 20 controls. Additionally, we looked whether the strength of dynamical connections in the migrainous brain is initially different. The examined network consisted of the secondary somatosensory areas (lS2, rS2), insulae (lIns, rIns), anterior cingulate cortex (ACC), contralateral primary somatosensory cortex (lS1), and a hidden source assumed to represent the thalamus. Results suggest that migraine patients show initially heightened communication between lS1 and the thalamus, in both directions. After repetitive stimulations, connection strengths from the thalamus to all somatosensory areas habituated in controls whereas this was not apparent in migraine. Together with further abnormalities in initial connectivity strengths and modulations between the thalamus and the insulae, these results are in line with altered thalamo-cortical network dynamics in migraine. Group differences in connectivity from and to the insulae including interhemispheric connections, suggests an important role of the insulae.
Keywords
computational neuroscience, migraine, EEG, LEP, habituation, pain, DCM, connectivity, CONNECTIVITY, HEADACHE, INSIGHTS, INSULA, CORTEX

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MLA
Bassez, Iege, et al. “Dynamic Causal Modelling of the Reduced Habituation to Painful Stimuli in Migraine : An EEG Study.” BRAIN SCIENCES, vol. 10, no. 10, 2020, doi:10.3390/brainsci10100712.
APA
Bassez, I., Van de Steen, F., Ricci, K., Vecchio, E., Gentile, E., Marinazzo, D., & de Tommaso, M. (2020). Dynamic causal modelling of the reduced habituation to painful stimuli in migraine : an EEG study. BRAIN SCIENCES, 10(10). https://doi.org/10.3390/brainsci10100712
Chicago author-date
Bassez, Iege, Frederik Van de Steen, Katia Ricci, Eleonora Vecchio, Eleonora Gentile, Daniele Marinazzo, and Marina de Tommaso. 2020. “Dynamic Causal Modelling of the Reduced Habituation to Painful Stimuli in Migraine : An EEG Study.” BRAIN SCIENCES 10 (10). https://doi.org/10.3390/brainsci10100712.
Chicago author-date (all authors)
Bassez, Iege, Frederik Van de Steen, Katia Ricci, Eleonora Vecchio, Eleonora Gentile, Daniele Marinazzo, and Marina de Tommaso. 2020. “Dynamic Causal Modelling of the Reduced Habituation to Painful Stimuli in Migraine : An EEG Study.” BRAIN SCIENCES 10 (10). doi:10.3390/brainsci10100712.
Vancouver
1.
Bassez I, Van de Steen F, Ricci K, Vecchio E, Gentile E, Marinazzo D, et al. Dynamic causal modelling of the reduced habituation to painful stimuli in migraine : an EEG study. BRAIN SCIENCES. 2020;10(10).
IEEE
[1]
I. Bassez et al., “Dynamic causal modelling of the reduced habituation to painful stimuli in migraine : an EEG study,” BRAIN SCIENCES, vol. 10, no. 10, 2020.
@article{8677128,
  abstract     = {{A consistent finding in migraine is reduced cortical habituation to repetitive sensory stimuli. This study investigated brain dynamics underlying the atypical habituation to painful stimuli in interictal migraine. We investigated modulations in effective connectivity between the sources of laser evoked potentials (LEPs) from a first to final block of trigeminal LEPs using dynamic causal modelling (DCM) in a group of 23 migraine patients and 20 controls. Additionally, we looked whether the strength of dynamical connections in the migrainous brain is initially different. The examined network consisted of the secondary somatosensory areas (lS2, rS2), insulae (lIns, rIns), anterior cingulate cortex (ACC), contralateral primary somatosensory cortex (lS1), and a hidden source assumed to represent the thalamus. Results suggest that migraine patients show initially heightened communication between lS1 and the thalamus, in both directions. After repetitive stimulations, connection strengths from the thalamus to all somatosensory areas habituated in controls whereas this was not apparent in migraine. Together with further abnormalities in initial connectivity strengths and modulations between the thalamus and the insulae, these results are in line with altered thalamo-cortical network dynamics in migraine. Group differences in connectivity from and to the insulae including interhemispheric connections, suggests an important role of the insulae.}},
  articleno    = {{712}},
  author       = {{Bassez, Iege and Van de Steen, Frederik and Ricci, Katia and Vecchio, Eleonora and Gentile, Eleonora and Marinazzo, Daniele and de Tommaso, Marina}},
  issn         = {{2076-3425}},
  journal      = {{BRAIN SCIENCES}},
  keywords     = {{computational neuroscience,migraine,EEG,LEP,habituation,pain,DCM,connectivity,CONNECTIVITY,HEADACHE,INSIGHTS,INSULA,CORTEX}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{11}},
  title        = {{Dynamic causal modelling of the reduced habituation to painful stimuli in migraine : an EEG study}},
  url          = {{http://doi.org/10.3390/brainsci10100712}},
  volume       = {{10}},
  year         = {{2020}},
}
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