A role for Interleukin-1 in the invivo actions of tumor necrosis factor
- Author
- Peter Brouckaert (UGent) , Claude Libert (UGent) , Bart Everaerdt, Nozomi Takahashi (UGent) and Walter Fiers
- Organization
- Abstract
- We have observed a marked species specificity in the in vivo antitumor, shock-inducing and Interleukin-6 (IL-6)-inducing activities of human recombinant TNF (hrTNF) versus murine rTNF (mrTNF) in mouse models. We also have observed that this species specificity can be abolished when synergistic factors are co-administered. We now present data showing that the profiles of induced IL-6 and TNF after lethal and non-lethal doses of endotoxin are different. These results are discussed in the context of a model of dual signalling for the induction of the major post-endotoxin phenomena that takes into consideration the involvement of Interleukin-1 (IL-1) in the in vivo actions of TNF.
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8676294
- MLA
- Brouckaert, Peter, et al. “A Role for Interleukin-1 in the Invivo Actions of Tumor Necrosis Factor.” LYMPHOKINE RESEARCH, vol. 8, no. 3, 1989, pp. 269–74.
- APA
- Brouckaert, P., Libert, C., Everaerdt, B., Takahashi, N., & Fiers, W. (1989). A role for Interleukin-1 in the invivo actions of tumor necrosis factor. LYMPHOKINE RESEARCH, 8(3), 269–274.
- Chicago author-date
- Brouckaert, Peter, Claude Libert, Bart Everaerdt, Nozomi Takahashi, and Walter Fiers. 1989. “A Role for Interleukin-1 in the Invivo Actions of Tumor Necrosis Factor.” LYMPHOKINE RESEARCH 8 (3): 269–74.
- Chicago author-date (all authors)
- Brouckaert, Peter, Claude Libert, Bart Everaerdt, Nozomi Takahashi, and Walter Fiers. 1989. “A Role for Interleukin-1 in the Invivo Actions of Tumor Necrosis Factor.” LYMPHOKINE RESEARCH 8 (3): 269–274.
- Vancouver
- 1.Brouckaert P, Libert C, Everaerdt B, Takahashi N, Fiers W. A role for Interleukin-1 in the invivo actions of tumor necrosis factor. LYMPHOKINE RESEARCH. 1989;8(3):269–74.
- IEEE
- [1]P. Brouckaert, C. Libert, B. Everaerdt, N. Takahashi, and W. Fiers, “A role for Interleukin-1 in the invivo actions of tumor necrosis factor,” LYMPHOKINE RESEARCH, vol. 8, no. 3, pp. 269–274, 1989.
@article{8676294,
abstract = {{We have observed a marked species specificity in the in vivo antitumor, shock-inducing and Interleukin-6 (IL-6)-inducing activities of human recombinant TNF (hrTNF) versus murine rTNF (mrTNF) in mouse models. We also have observed that this species specificity can be abolished when synergistic factors are co-administered. We now present data showing that the profiles of induced IL-6 and TNF after lethal and non-lethal doses of endotoxin are different. These results are discussed in the context of a model of dual signalling for the induction of the major post-endotoxin phenomena that takes into consideration the involvement of Interleukin-1 (IL-1) in the in vivo actions of TNF.}},
author = {{Brouckaert, Peter and Libert, Claude and Everaerdt, Bart and Takahashi, Nozomi and Fiers, Walter}},
issn = {{0277-6766}},
journal = {{LYMPHOKINE RESEARCH}},
language = {{eng}},
number = {{3}},
pages = {{269--274}},
title = {{A role for Interleukin-1 in the invivo actions of tumor necrosis factor}},
volume = {{8}},
year = {{1989}},
}