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Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver

Anneleen Remmerie (UGent) , Liesbet Martens (UGent) , Tinne Thoné (UGent) , Angela Castoldi, Ruth Seurinck (UGent) , Benjamin Pavie (UGent) , Joris Roels (UGent) , Bavo Vanneste (UGent) , Sofie De Prijck (UGent) , Mathias Vanhockerhout (UGent) , et al.
(2020) IMMUNITY. 53(3). p.641-657.e1–e14
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Abstract
Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs), are suggested to play important roles in the pathogenesis of MAFLD through their activation, although the exact roles played by these cells remain unclear. Here, we demonstrated that KCs were reduced in MAFLD being replaced by macrophages originating from the bone marrow. Recruited macrophages existed in two subsets with distinct activation states, either closely resembling homeostatic KCs or lipid-associated macrophages (LAMs) from obese adipose tissue. Hepatic LAMs expressed Osteopontin, a biomarker for patients with NASH, linked with the development of fibrosis. Fitting with this, LAMs were found in regions of the liver with reduced numbers of KCs, characterized by increased Desmin expression. Together, our data highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in MAFLD.
Keywords
STEATOHEPATITIS, FIBROSIS, INFLAMMATION, SIGNATURES, STEATOSIS, NETWORK, DISEASE, MODEL

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MLA
Remmerie, Anneleen, et al. “Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.” IMMUNITY, vol. 53, no. 3, Cell Press, 2020, pp. 641-657.e1–e14, doi:10.1016/j.immuni.2020.08.004.
APA
Remmerie, A., Martens, L., Thoné, T., Castoldi, A., Seurinck, R., Pavie, B., … Scott, C. (2020). Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver. IMMUNITY, 53(3), 641-657.e1–e14. https://doi.org/10.1016/j.immuni.2020.08.004
Chicago author-date
Remmerie, Anneleen, Liesbet Martens, Tinne Thoné, Angela Castoldi, Ruth Seurinck, Benjamin Pavie, Joris Roels, et al. 2020. “Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.” IMMUNITY 53 (3): 641-657.e1–e14. https://doi.org/10.1016/j.immuni.2020.08.004.
Chicago author-date (all authors)
Remmerie, Anneleen, Liesbet Martens, Tinne Thoné, Angela Castoldi, Ruth Seurinck, Benjamin Pavie, Joris Roels, Bavo Vanneste, Sofie De Prijck, Mathias Vanhockerhout, Mushida Binte Abdul Latib, Lindsey Devisscher, Anne Hoorens, Johnny Bonnardel, Niels Vandamme, Anna Kremer, Peter Borghgraef, Hans Van Vlierberghe, Saskia Lippens, Edward Pearce, Yvan Saeys, and Charlotte Scott. 2020. “Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.” IMMUNITY 53 (3): 641-657.e1–e14. doi:10.1016/j.immuni.2020.08.004.
Vancouver
1.
Remmerie A, Martens L, Thoné T, Castoldi A, Seurinck R, Pavie B, et al. Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver. IMMUNITY. 2020;53(3):641-657.e1–e14.
IEEE
[1]
A. Remmerie et al., “Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver,” IMMUNITY, vol. 53, no. 3, pp. 641-657.e1–e14, 2020.
@article{8676252,
  abstract     = {{Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs), are suggested to play important roles in the pathogenesis of MAFLD through their activation, although the exact roles played by these cells remain unclear. Here, we demonstrated that KCs were reduced in MAFLD being replaced by macrophages originating from the bone marrow. Recruited macrophages existed in two subsets with distinct activation states, either closely resembling homeostatic KCs or lipid-associated macrophages (LAMs) from obese adipose tissue. Hepatic LAMs expressed Osteopontin, a biomarker for patients with NASH, linked with the development of fibrosis. Fitting with this, LAMs were found in regions of the liver with reduced numbers of KCs, characterized by increased Desmin expression. Together, our data highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in MAFLD.}},
  author       = {{Remmerie, Anneleen and Martens, Liesbet and Thoné, Tinne and Castoldi, Angela and Seurinck, Ruth and Pavie, Benjamin and Roels, Joris and Vanneste, Bavo and De Prijck, Sofie and Vanhockerhout, Mathias and Binte Abdul Latib, Mushida and Devisscher, Lindsey and Hoorens, Anne and Bonnardel, Johnny and Vandamme, Niels and Kremer, Anna and Borghgraef, Peter and Van Vlierberghe, Hans and Lippens, Saskia and Pearce, Edward and Saeys, Yvan and Scott, Charlotte}},
  issn         = {{1074-7613}},
  journal      = {{IMMUNITY}},
  keywords     = {{STEATOHEPATITIS,FIBROSIS,INFLAMMATION,SIGNATURES,STEATOSIS,NETWORK,DISEASE,MODEL}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{641--657.e1–e14}},
  publisher    = {{Cell Press}},
  title        = {{Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver}},
  url          = {{http://dx.doi.org/10.1016/j.immuni.2020.08.004}},
  volume       = {{53}},
  year         = {{2020}},
}

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