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Design and development of a reinforced tubular electrospun construct for the repair of ruptures of deep flexor tendons

Nele Pien (UGent) , Ian Peeters (UGent) , Liesbet Deconinck (UGent) , Lana Van Damme (UGent) , Lieven De Wilde (UGent) , Ann Martens (UGent) , Sandra Van Vlierberghe (UGent) , Peter Dubruel (UGent) and Arn Mignon (UGent)
(2021) MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 119.
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Abstract
This research aims at developing a more potent solution for deep flexor tendon repair by combining a mechanical and biological approach. A reinforced, multi-layered electrospun tubular construct is developed, composed of three layers: an inner electrospun layer containing an anti-inflammatory component (Naproxen), a middle layer of braided monofilament as reinforcement and an outer electrospun layer containing an anti adhesion component (hyaluronic acid, HA). In a first step, a novel acrylate endcapped urethane-based precursor (AUP) is developed and characterized by measuring molar mass, acrylate content and thermo-stability. The AUP material is benchmarked against commercially available poly(epsilon-caprolactone) (PCL). Next, the materials are processed into multi-layered, tubular constructs with bio-active components (Naproxen and HA) using electrospinning. In vitro assays using human fibroblasts show that incorporation of the bio-active components is successful and not-cytotoxic. Moreover, tensile testing using ex vivo sheep tendons prove that the developed multi-layered constructs fulfill the required strength for tendon repair (i.e. 2.79-3.98 MPa), with an ultimate strength of 8.56 +/- 1.92 MPa and 8.36 +/- 0.57 MPa for PCL and AUP/PCL constructs respectively. In conclusion, by combining a mechanical approach (improved mechanical properties) with the incorporation of bioactive compounds (biological approach), this solution shows its potential for application in deep flexor tendon repair.
Keywords
Deep flexor tendon repair, Tubular construct, Electrospinning, Acrylate endcapped urethane-based poly(ε- caprolactone), Ex vivo sheep tendon, MESENCHYMAL STEM-CELLS, MODIFIED KESSLER, SCAFFOLDS, PREVENTION, DELIVERY, SHEATH

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MLA
Pien, Nele, et al. “Design and Development of a Reinforced Tubular Electrospun Construct for the Repair of Ruptures of Deep Flexor Tendons.” MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 119, 2021, doi:10.1016/j.msec.2020.111504.
APA
Pien, N., Peeters, I., Deconinck, L., Van Damme, L., De Wilde, L., Martens, A., … Mignon, A. (2021). Design and development of a reinforced tubular electrospun construct for the repair of ruptures of deep flexor tendons. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 119. https://doi.org/10.1016/j.msec.2020.111504
Chicago author-date
Pien, Nele, Ian Peeters, Liesbet Deconinck, Lana Van Damme, Lieven De Wilde, Ann Martens, Sandra Van Vlierberghe, Peter Dubruel, and Arn Mignon. 2021. “Design and Development of a Reinforced Tubular Electrospun Construct for the Repair of Ruptures of Deep Flexor Tendons.” MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 119. https://doi.org/10.1016/j.msec.2020.111504.
Chicago author-date (all authors)
Pien, Nele, Ian Peeters, Liesbet Deconinck, Lana Van Damme, Lieven De Wilde, Ann Martens, Sandra Van Vlierberghe, Peter Dubruel, and Arn Mignon. 2021. “Design and Development of a Reinforced Tubular Electrospun Construct for the Repair of Ruptures of Deep Flexor Tendons.” MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 119. doi:10.1016/j.msec.2020.111504.
Vancouver
1.
Pien N, Peeters I, Deconinck L, Van Damme L, De Wilde L, Martens A, et al. Design and development of a reinforced tubular electrospun construct for the repair of ruptures of deep flexor tendons. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 2021;119.
IEEE
[1]
N. Pien et al., “Design and development of a reinforced tubular electrospun construct for the repair of ruptures of deep flexor tendons,” MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 119, 2021.
@article{8676118,
  abstract     = {{This research aims at developing a more potent solution for deep flexor tendon repair by combining a mechanical and biological approach. A reinforced, multi-layered electrospun tubular construct is developed, composed of three layers: an inner electrospun layer containing an anti-inflammatory component (Naproxen), a middle layer of braided monofilament as reinforcement and an outer electrospun layer containing an anti adhesion component (hyaluronic acid, HA). In a first step, a novel acrylate endcapped urethane-based precursor (AUP) is developed and characterized by measuring molar mass, acrylate content and thermo-stability. The AUP material is benchmarked against commercially available poly(epsilon-caprolactone) (PCL). Next, the materials are processed into multi-layered, tubular constructs with bio-active components (Naproxen and HA) using electrospinning. In vitro assays using human fibroblasts show that incorporation of the bio-active components is successful and not-cytotoxic. Moreover, tensile testing using ex vivo sheep tendons prove that the developed multi-layered constructs fulfill the required strength for tendon repair (i.e. 2.79-3.98 MPa), with an ultimate strength of 8.56 +/- 1.92 MPa and 8.36 +/- 0.57 MPa for PCL and AUP/PCL constructs respectively. In conclusion, by combining a mechanical approach (improved mechanical properties) with the incorporation of bioactive compounds (biological approach), this solution shows its potential for application in deep flexor tendon repair.}},
  articleno    = {{111504}},
  author       = {{Pien, Nele and Peeters, Ian and Deconinck, Liesbet and Van Damme, Lana and De Wilde, Lieven and Martens, Ann and Van Vlierberghe, Sandra and Dubruel, Peter and Mignon, Arn}},
  issn         = {{0928-4931}},
  journal      = {{MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS}},
  keywords     = {{Deep flexor tendon repair,Tubular construct,Electrospinning,Acrylate endcapped urethane-based poly(ε- caprolactone),Ex vivo sheep tendon,MESENCHYMAL STEM-CELLS,MODIFIED KESSLER,SCAFFOLDS,PREVENTION,DELIVERY,SHEATH}},
  language     = {{eng}},
  pages        = {{12}},
  title        = {{Design and development of a reinforced tubular electrospun construct for the repair of ruptures of deep flexor tendons}},
  url          = {{http://dx.doi.org/10.1016/j.msec.2020.111504}},
  volume       = {{119}},
  year         = {{2021}},
}
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