@article{8675526,
  abstract     = {{Seizures are common in patients with high-grade gliomas (30–60%) and approximately 15–30% of glioblastoma (GB) patients develop drug-resistant epilepsy. Reliable animal models are needed to develop adequate treatments for glioma-related epilepsy. Therefore, fifteen rats were inoculated with F98 GB cells (GB group) and four rats with vehicle only (control group) in the right entorhinal cortex. MRI was performed to visualize tumor presence. A subset of seven GB and two control rats were implanted with recording electrodes to determine the occurrence of epileptic seizures with video-EEG recording over multiple days. In a subset of rats, tumor size and expression of tumor markers were investigated with histology or mRNA in situ hybridization. Tumors were visible on MRI six days post-inoculation. Time-dependent changes in tumor morphology and size were visible on MRI. Epileptic seizures were detected in all GB rats monitored with video-EEG. Twenty-one days after inoculation, rats were euthanized based on signs of discomfort and pain. This study describes, for the first time, reproducible tumor growth and spontaneous seizures upon inoculation of F98 cells in the rat entorhinal cortex. The development of this new model of GB-related epilepsy may be valuable to design new therapies against tumor growth and associated epileptic seizures.}},
  articleno    = {{6999}},
  author       = {{Bouckaert, Charlotte and Germonpré, Charlotte and Verhoeven, Jeroen and Chong, Seon-Ah and Jacquin, Lucas and Mairet-Coello, Georges and André, Véronique Marie and Leclercq, Karine and Vanhove, Christian and De Vos, Filip and Van den Broecke, Caroline and Goethals, Ingeborg and Descamps, Benedicte and Donche, Sam and Carrette, Evelien and Wadman, Wytse and Boon, Paul and Vonck, Kristl and Raedt, Robrecht}},
  issn         = {{1422-0067}},
  journal      = {{INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}},
  keywords     = {{Physical and Theoretical Chemistry,Inorganic Chemistry,Organic Chemistry,Spectroscopy,Molecular Biology,Catalysis,General Medicine,Computer Science Applications,glioma,seizures,high-grade glioma rat model,glioma-related epilepsy,video-EEG monitoring,TUMOR-ASSOCIATED EPILEPSY,BRAIN-TUMOR,PATHOPHYSIOLOGY,MANAGEMENT,GLUTAMATE,SEIZURES}},
  language     = {{eng}},
  number       = {{19}},
  pages        = {{19}},
  title        = {{Development of a rat model for glioma-related epilepsy}},
  url          = {{http://doi.org/10.3390/ijms21196999}},
  volume       = {{21}},
  year         = {{2020}},
}

Altmetric

View in Altmetric

Web of Science

Times cited: