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The RNA Atlas, a single nucleotide resolution map of the human transcriptome

Author
Organization
Abstract
<jats:title>Abstract</jats:title><jats:p>The human transcriptome consists of various RNA biotypes including multiple types of non-coding RNAs (ncRNAs). Current ncRNA compendia remain incomplete partially because they are almost exclusively derived from the interrogation of small- and polyadenylated RNAs. Here, we present a more comprehensive atlas of the human transcriptome that is derived from matching polyA-, total-, and small-RNA profiles of a heterogeneous collection of nearly 300 human tissues and cell lines. We report on thousands of novel RNA species across all major RNA biotypes, including a hitherto poorly-cataloged class of non-polyadenylated single-exon long non-coding RNAs. In addition, we exploit intron abundance estimates from total RNA-sequencing to test and verify functional regulation by novel non-coding RNAs. Our study represents a substantial expansion of the current catalogue of human ncRNAs and their regulatory interactions. All data, analyses, and results are available in the R2 web portal and serve as a basis to further explore RNA biology and function.</jats:p>

Citation

Please use this url to cite or link to this publication:

MLA
Lorenzi, Lucia, et al. “The RNA Atlas, a Single Nucleotide Resolution Map of the Human Transcriptome.” BioRxiv, 2019, doi:10.1101/807529.
APA
Lorenzi, L., Chiu, H.-S., Avila Cobos, F., Gross, S., Volders, P.-J., Cannoodt, R., … Mestdagh, P. (2019). The RNA Atlas, a single nucleotide resolution map of the human transcriptome. bioRxiv. https://doi.org/10.1101/807529
Chicago author-date
Lorenzi, Lucia, Hua-Sheng Chiu, Francisco Avila Cobos, Stephen Gross, Pieter-Jan Volders, Robrecht Cannoodt, Justine Nuytens, et al. 2019. “The RNA Atlas, a Single Nucleotide Resolution Map of the Human Transcriptome.” BioRxiv. https://doi.org/10.1101/807529.
Chicago author-date (all authors)
Lorenzi, Lucia, Hua-Sheng Chiu, Francisco Avila Cobos, Stephen Gross, Pieter-Jan Volders, Robrecht Cannoodt, Justine Nuytens, Katrien Vanderheyden, Jasper Anckaert, Steve Lefever, Tine Goovaerts, Thomas Birkballe Hansen, Scott Kuersten, Nele Nijs, Tom Taghon, Karim Vermaelen, Ken Bracke, Yvan Saeys, Tim De Meyer, Nandan Deshpande, Govardhan Anande, Ting-Wen Chen, Marc R. Wilkins, Ashwin Unnikrishnan, Katleen De Preter, Jørgen Kjems, Jan Koster, Gary P. Schroth, Jo Vandesompele, Pavel Sumazin, and Pieter Mestdagh. 2019. “The RNA Atlas, a Single Nucleotide Resolution Map of the Human Transcriptome.” BioRxiv. doi:10.1101/807529.
Vancouver
1.
Lorenzi L, Chiu H-S, Avila Cobos F, Gross S, Volders P-J, Cannoodt R, et al. The RNA Atlas, a single nucleotide resolution map of the human transcriptome. bioRxiv. 2019.
IEEE
[1]
L. Lorenzi et al., “The RNA Atlas, a single nucleotide resolution map of the human transcriptome,” bioRxiv. 2019.
@misc{8675222,
  abstract     = {<jats:title>Abstract</jats:title><jats:p>The human transcriptome consists of various RNA biotypes including multiple types of non-coding RNAs (ncRNAs). Current ncRNA compendia remain incomplete partially because they are almost exclusively derived from the interrogation of small- and polyadenylated RNAs. Here, we present a more comprehensive atlas of the human transcriptome that is derived from matching polyA-, total-, and small-RNA profiles of a heterogeneous collection of nearly 300 human tissues and cell lines. We report on thousands of novel RNA species across all major RNA biotypes, including a hitherto poorly-cataloged class of non-polyadenylated single-exon long non-coding RNAs. In addition, we exploit intron abundance estimates from total RNA-sequencing to test and verify functional regulation by novel non-coding RNAs. Our study represents a substantial expansion of the current catalogue of human ncRNAs and their regulatory interactions. All data, analyses, and results are available in the R2 web portal and serve as a basis to further explore RNA biology and function.</jats:p>},
  author       = {Lorenzi, Lucia and Chiu, Hua-Sheng and Avila Cobos, Francisco and Gross, Stephen and Volders, Pieter-Jan and Cannoodt, Robrecht and Nuytens, Justine and Vanderheyden, Katrien and Anckaert, Jasper and Lefever, Steve and Goovaerts, Tine and Hansen, Thomas Birkballe and Kuersten, Scott and Nijs, Nele and Taghon, Tom and Vermaelen, Karim and Bracke, Ken and Saeys, Yvan and De Meyer, Tim and Deshpande, Nandan and Anande, Govardhan and Chen, Ting-Wen and Wilkins, Marc R. and Unnikrishnan, Ashwin and De Preter, Katleen and Kjems, Jørgen and Koster, Jan and Schroth, Gary P. and Vandesompele, Jo and Sumazin, Pavel and Mestdagh, Pieter},
  language     = {und},
  series       = {bioRxiv},
  title        = {The RNA Atlas, a single nucleotide resolution map of the human transcriptome},
  url          = {http://dx.doi.org/10.1101/807529},
  year         = {2019},
}

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