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Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive F-19 MRI contrast agents

Ondrej Sedlacek (UGent) , Daniel Jirak, Martin Vit, Natalia Ziolkowska, Olga Janouskova and Richard Hoogenboom (UGent)
(2020) MACROMOLECULES. 53(15). p.6387-6395
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Abstract
Recently, F-19 magnetic resonance imaging (MRI) emerged as a powerful noninvasive diagnostic tool in modern medicine. Fluorinated polymer materials represent an attractive class of MRI contrast agents (CAs) due to their structural variability and tunable properties. Herein, we describe for the first time the F-19 MRI of CAs based on fluorinated water-soluble poly(2-oxazoline)s (PAOx), a polymer class with increasing popularity in biomedical sciences. A series of fluorinated PAOx with increasing fluorine content were synthesized by controlled side-chain hydrolysis of poly(2- methyl-2-oxazoline) followed by reacylation of its ethylenimine units by difluoroacetic anhydride. As the increasing fluorine content leads to the copolymer hydrophobization, their composition was optimized for maximal F-19 MRI performance while retaining good solubility in water. The magnetic properties of the water-soluble polymers were studied in vitro by F-19 NMR and MRI, revealing their outstanding relaxation properties and imaging sensitivity. All CAs were found to be noncytotoxic for HeLa cells in vitro. Finally, the diagnostic potential of the new CAs was demonstrated by a successful in vivo F-19 MRI visualization of the selected fluorinated polymer in rats.
Keywords
RING-OPENING POLYMERIZATION, MAGNETIC-RESONANCE, IN-VITRO, POLY(2-ETHYL-2-OXAZOLINE), COPOLYMERS, DESIGN, HYDROLYSIS

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MLA
Sedlacek, Ondrej, et al. “Fluorinated Water-Soluble Poly(2-Oxazoline)s as Highly Sensitive F-19 MRI Contrast Agents.” MACROMOLECULES, vol. 53, no. 15, 2020, pp. 6387–95, doi:10.1021/acs.macromol.0c01228.
APA
Sedlacek, O., Jirak, D., Vit, M., Ziolkowska, N., Janouskova, O., & Hoogenboom, R. (2020). Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive F-19 MRI contrast agents. MACROMOLECULES, 53(15), 6387–6395. https://doi.org/10.1021/acs.macromol.0c01228
Chicago author-date
Sedlacek, Ondrej, Daniel Jirak, Martin Vit, Natalia Ziolkowska, Olga Janouskova, and Richard Hoogenboom. 2020. “Fluorinated Water-Soluble Poly(2-Oxazoline)s as Highly Sensitive F-19 MRI Contrast Agents.” MACROMOLECULES 53 (15): 6387–95. https://doi.org/10.1021/acs.macromol.0c01228.
Chicago author-date (all authors)
Sedlacek, Ondrej, Daniel Jirak, Martin Vit, Natalia Ziolkowska, Olga Janouskova, and Richard Hoogenboom. 2020. “Fluorinated Water-Soluble Poly(2-Oxazoline)s as Highly Sensitive F-19 MRI Contrast Agents.” MACROMOLECULES 53 (15): 6387–6395. doi:10.1021/acs.macromol.0c01228.
Vancouver
1.
Sedlacek O, Jirak D, Vit M, Ziolkowska N, Janouskova O, Hoogenboom R. Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive F-19 MRI contrast agents. MACROMOLECULES. 2020;53(15):6387–95.
IEEE
[1]
O. Sedlacek, D. Jirak, M. Vit, N. Ziolkowska, O. Janouskova, and R. Hoogenboom, “Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive F-19 MRI contrast agents,” MACROMOLECULES, vol. 53, no. 15, pp. 6387–6395, 2020.
@article{8674778,
  abstract     = {{Recently, F-19 magnetic resonance imaging (MRI) emerged as a powerful noninvasive diagnostic tool in modern medicine. Fluorinated polymer materials represent an attractive class of MRI contrast agents (CAs) due to their structural variability and tunable properties. Herein, we describe for the first time the F-19 MRI of CAs based on fluorinated water-soluble poly(2-oxazoline)s (PAOx), a polymer class with increasing popularity in biomedical sciences. A series of fluorinated PAOx with increasing fluorine content were synthesized by controlled side-chain hydrolysis of poly(2- methyl-2-oxazoline) followed by reacylation of its ethylenimine units by difluoroacetic anhydride. As the increasing fluorine content leads to the copolymer hydrophobization, their composition was optimized for maximal F-19 MRI performance while retaining good solubility in water. The magnetic properties of the water-soluble polymers were studied in vitro by F-19 NMR and MRI, revealing their outstanding relaxation properties and imaging sensitivity. All CAs were found to be noncytotoxic for HeLa cells in vitro. Finally, the diagnostic potential of the new CAs was demonstrated by a successful in vivo F-19 MRI visualization of the selected fluorinated polymer in rats.}},
  author       = {{Sedlacek, Ondrej and Jirak, Daniel and Vit, Martin and Ziolkowska, Natalia and Janouskova, Olga and Hoogenboom, Richard}},
  issn         = {{0024-9297}},
  journal      = {{MACROMOLECULES}},
  keywords     = {{RING-OPENING POLYMERIZATION,MAGNETIC-RESONANCE,IN-VITRO,POLY(2-ETHYL-2-OXAZOLINE),COPOLYMERS,DESIGN,HYDROLYSIS}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{6387--6395}},
  title        = {{Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive F-19 MRI contrast agents}},
  url          = {{http://doi.org/10.1021/acs.macromol.0c01228}},
  volume       = {{53}},
  year         = {{2020}},
}
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