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International variation in the management of severe COVID-19 patients

Elie Azoulay, Jan De Waele (UGent) , Ricard Ferrer, Thomas Staudinger, Marta Borkowska (UGent) , Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar-Hari, et al.
(2020) CRITICAL CARE. 24(1).
Author
Organization
Abstract
Background There is little evidence to support the management of severe COVID-19 patients. Methods To document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection. Results A total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated. Conclusions There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.
Keywords
Critical Care and Intensive Care Medicine, Coronavirus, Acute respiratory distress syndrome, Viral infection, Remdesivir

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MLA
Azoulay, Elie, et al. “International Variation in the Management of Severe COVID-19 Patients.” CRITICAL CARE, vol. 24, no. 1, 2020, doi:10.1186/s13054-020-03194-w.
APA
Azoulay, E., De Waele, J., Ferrer, R., Staudinger, T., Borkowska, M., Povoa, P., … Cecconi, M. (2020). International variation in the management of severe COVID-19 patients. CRITICAL CARE, 24(1). https://doi.org/10.1186/s13054-020-03194-w
Chicago author-date
Azoulay, Elie, Jan De Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, et al. 2020. “International Variation in the Management of Severe COVID-19 Patients.” CRITICAL CARE 24 (1). https://doi.org/10.1186/s13054-020-03194-w.
Chicago author-date (all authors)
Azoulay, Elie, Jan De Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar-Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu, and Maurizio Cecconi. 2020. “International Variation in the Management of Severe COVID-19 Patients.” CRITICAL CARE 24 (1). doi:10.1186/s13054-020-03194-w.
Vancouver
1.
Azoulay E, De Waele J, Ferrer R, Staudinger T, Borkowska M, Povoa P, et al. International variation in the management of severe COVID-19 patients. CRITICAL CARE. 2020;24(1).
IEEE
[1]
E. Azoulay et al., “International variation in the management of severe COVID-19 patients,” CRITICAL CARE, vol. 24, no. 1, 2020.
@article{8673815,
  abstract     = {{Background There is little evidence to support the management of severe COVID-19 patients. Methods To document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection. Results A total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated. Conclusions There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.}},
  articleno    = {{486}},
  author       = {{Azoulay, Elie and De Waele, Jan and Ferrer, Ricard and Staudinger, Thomas and Borkowska, Marta and Povoa, Pedro and Iliopoulou, Katerina and Artigas, Antonio and Schaller, Stefan J. and Shankar-Hari, Manu and Pellegrini, Mariangela and Darmon, Michael and Kesecioglu, Jozef and Cecconi, Maurizio}},
  issn         = {{1466-609X}},
  journal      = {{CRITICAL CARE}},
  keywords     = {{Critical Care and Intensive Care Medicine,Coronavirus,Acute respiratory distress syndrome,Viral infection,Remdesivir}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{7}},
  title        = {{International variation in the management of severe COVID-19 patients}},
  url          = {{http://dx.doi.org/10.1186/s13054-020-03194-w}},
  volume       = {{24}},
  year         = {{2020}},
}
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