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The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum

Lachlan Dow, Frederike Stock genannt Schroer, Alexandra Peltekis, David Szamosvari, Michaela Prothiwa, Adrien Lapointe, Thomas Boettcher, Benjamin Bailleul, Wim Vyverman (UGent) , Peter G. Kroth, et al.
(2020) CHEMBIOCHEM. 21(8). p.1206-1216
Author
Organization
Abstract
The mechanisms underlying interactions between diatoms and bacteria are crucial to understand diatom behaviour and proliferation, and can result in far-reaching ecological consequences. Recently, 2-alkyl-4-quinolones have been isolated from marine bacteria, both of which (the bacterium and isolated chemical) inhibited growth of microalgae, suggesting these compounds could mediate diatom-bacteria interactions. The effects of several quinolones on three diatom species have been investigated. The growth of all three was inhibited, with half-maximal inhibitory concentrations reaching the sub-micromolar range. By using multiple techniques, dual inhibition mechanisms were uncovered for 2-heptyl-4-quinolone (HHQ) in Phaeodactylum tricornutum. Firstly, photosynthetic electron transport was obstructed, primarily through inhibition of the cytochrome b(6)f complex. Secondly, respiration was inhibited, leading to repression of ATP supply to plastids from mitochondria through organelle energy coupling. These data clearly show how HHQ could modulate diatom proliferation in marine environments.
Keywords
MARINE ALTEROMONAS SP, PHOTOSYSTEM-II, N-OXIDES, PSEUDOMONAS-AERUGINOSA, QUANTUM YIELD, QUINOLONES, cytochromes, diatom-bacteria interactions, photosynthesis, quinolones, reaction mechanisms

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MLA
Dow, Lachlan, et al. “The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum Tricornutum.” CHEMBIOCHEM, vol. 21, no. 8, 2020, pp. 1206–16, doi:10.1002/cbic.201900612.
APA
Dow, L., Stock genannt Schroer, F., Peltekis, A., Szamosvari, D., Prothiwa, M., Lapointe, A., … Lepetit, B. (2020). The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum. CHEMBIOCHEM, 21(8), 1206–1216. https://doi.org/10.1002/cbic.201900612
Chicago author-date
Dow, Lachlan, Frederike Stock genannt Schroer, Alexandra Peltekis, David Szamosvari, Michaela Prothiwa, Adrien Lapointe, Thomas Boettcher, et al. 2020. “The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum Tricornutum.” CHEMBIOCHEM 21 (8): 1206–16. https://doi.org/10.1002/cbic.201900612.
Chicago author-date (all authors)
Dow, Lachlan, Frederike Stock genannt Schroer, Alexandra Peltekis, David Szamosvari, Michaela Prothiwa, Adrien Lapointe, Thomas Boettcher, Benjamin Bailleul, Wim Vyverman, Peter G. Kroth, and Bernard Lepetit. 2020. “The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum Tricornutum.” CHEMBIOCHEM 21 (8): 1206–1216. doi:10.1002/cbic.201900612.
Vancouver
1.
Dow L, Stock genannt Schroer F, Peltekis A, Szamosvari D, Prothiwa M, Lapointe A, et al. The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum. CHEMBIOCHEM. 2020;21(8):1206–16.
IEEE
[1]
L. Dow et al., “The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum,” CHEMBIOCHEM, vol. 21, no. 8, pp. 1206–1216, 2020.
@article{8673729,
  abstract     = {{The mechanisms underlying interactions between diatoms and bacteria are crucial to understand diatom behaviour and proliferation, and can result in far-reaching ecological consequences. Recently, 2-alkyl-4-quinolones have been isolated from marine bacteria, both of which (the bacterium and isolated chemical) inhibited growth of microalgae, suggesting these compounds could mediate diatom-bacteria interactions. The effects of several quinolones on three diatom species have been investigated. The growth of all three was inhibited, with half-maximal inhibitory concentrations reaching the sub-micromolar range. By using multiple techniques, dual inhibition mechanisms were uncovered for 2-heptyl-4-quinolone (HHQ) in Phaeodactylum tricornutum. Firstly, photosynthetic electron transport was obstructed, primarily through inhibition of the cytochrome b(6)f complex. Secondly, respiration was inhibited, leading to repression of ATP supply to plastids from mitochondria through organelle energy coupling. These data clearly show how HHQ could modulate diatom proliferation in marine environments.}},
  author       = {{Dow, Lachlan and Stock genannt Schroer, Frederike and Peltekis, Alexandra and Szamosvari, David and Prothiwa, Michaela and Lapointe, Adrien and Boettcher, Thomas and Bailleul, Benjamin and Vyverman, Wim and Kroth, Peter G. and Lepetit, Bernard}},
  issn         = {{1439-4227}},
  journal      = {{CHEMBIOCHEM}},
  keywords     = {{MARINE ALTEROMONAS SP,PHOTOSYSTEM-II,N-OXIDES,PSEUDOMONAS-AERUGINOSA,QUANTUM YIELD,QUINOLONES,cytochromes,diatom-bacteria interactions,photosynthesis,quinolones,reaction mechanisms}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1206--1216}},
  title        = {{The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum}},
  url          = {{http://doi.org/10.1002/cbic.201900612}},
  volume       = {{21}},
  year         = {{2020}},
}
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