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Nocturia is an independent predictor of abdominal aortic calcification in women : results from the National Health and Nutrition Examination Survey

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Abstract
Nocturia is generally considered a urological condition, but may be an indicator of cardiovascular disease, as prior studies have found associations with cardiovascular risk factors as well as clinical and subclinical markers of coronary artery disease. This study aimed to explore potential associations between nocturia and abdominal aortic calcification (AAC). We analyzed 2013-2014 National Health and Nutrition Examination Survey dual energy x-ray absorptiometry-derived AAC data and concurrent interview data on kidney conditions from respondents aged 40-80 years. AAC was defined as a score >= 1 on the 24-point semi-quantitative AAC scale. Nocturia was defined as an average of >= 2 voids per night. Three incremental multivariate logistic regression models controlling for (1) age, (2) sex, race, and BMI, and (3) hypertension, diabetes mellitus, and smoking history were used to determine whether nocturia predicted AAC. These models were and modified to exclude age and/or sex to perform age- and/or sex-specific sub-analyses, respectively. Complete data were available from 2,945 participants (29.1% AAC, 31.4% nocturia). On univariate analysis, the association between nocturia and AAC was significant in women (OR 1.77 [95% CI 1.37-2.29], p < 0.001), but not in men (1.14 [0.74-1.76], p = 0.531). Multivariate analysis showed nocturia was an independent predictor of AAC in women in Models I-II (ORs 1.49-1.58, p <= 0.032) but not Model III (1.37 [0.90-2.09], p = 0.133). Stratification by age revealed a strong univariate association among women aged 50-59 (3.88 [1.97-7.61], p < 0.001), which persisted across all multivariate models (ORs 4.05-4.41, p <= 0.001). The presence of nocturia is an important clue of AAC in women, especially those middle-aged.
Keywords
Public Health, Environmental and Occupational Health, Health(social science), AAC, Atherosclerosis, Cardiovascular, Nocturia, CORONARY-ARTERY CALCIUM, ENDOTHELIAL DYSFUNCTION, HEART-DISEASE, RISK, AGE, PROGRESSION, STIFFNESS, MORTALITY, QUALITY

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MLA
Khan, Saad Ahmed, et al. “Nocturia Is an Independent Predictor of Abdominal Aortic Calcification in Women : Results from the National Health and Nutrition Examination Survey.” JOURNAL OF COMMUNITY HEALTH, 2020, doi:10.1007/s10900-020-00893-x.
APA
Khan, S. A., Rahman, E. U., Chobufo, M. D., Yasin, A., Monaghan, T., Weiss, J., & Lazar, J. M. (2020). Nocturia is an independent predictor of abdominal aortic calcification in women : results from the National Health and Nutrition Examination Survey. JOURNAL OF COMMUNITY HEALTH. https://doi.org/10.1007/s10900-020-00893-x
Chicago author-date
Khan, Saad Ahmed, Ebad U. Rahman, Muchi Ditah Chobufo, Aneeq Yasin, Thomas Monaghan, Jeffrey Weiss, and Jason M. Lazar. 2020. “Nocturia Is an Independent Predictor of Abdominal Aortic Calcification in Women : Results from the National Health and Nutrition Examination Survey.” JOURNAL OF COMMUNITY HEALTH. https://doi.org/10.1007/s10900-020-00893-x.
Chicago author-date (all authors)
Khan, Saad Ahmed, Ebad U. Rahman, Muchi Ditah Chobufo, Aneeq Yasin, Thomas Monaghan, Jeffrey Weiss, and Jason M. Lazar. 2020. “Nocturia Is an Independent Predictor of Abdominal Aortic Calcification in Women : Results from the National Health and Nutrition Examination Survey.” JOURNAL OF COMMUNITY HEALTH. doi:10.1007/s10900-020-00893-x.
Vancouver
1.
Khan SA, Rahman EU, Chobufo MD, Yasin A, Monaghan T, Weiss J, et al. Nocturia is an independent predictor of abdominal aortic calcification in women : results from the National Health and Nutrition Examination Survey. JOURNAL OF COMMUNITY HEALTH. 2020;
IEEE
[1]
S. A. Khan et al., “Nocturia is an independent predictor of abdominal aortic calcification in women : results from the National Health and Nutrition Examination Survey,” JOURNAL OF COMMUNITY HEALTH, 2020.
@article{8670567,
  abstract     = {Nocturia is generally considered a urological condition, but may be an indicator of cardiovascular disease, as prior studies have found associations with cardiovascular risk factors as well as clinical and subclinical markers of coronary artery disease. This study aimed to explore potential associations between nocturia and abdominal aortic calcification (AAC). We analyzed 2013-2014 National Health and Nutrition Examination Survey dual energy x-ray absorptiometry-derived AAC data and concurrent interview data on kidney conditions from respondents aged 40-80 years. AAC was defined as a score >= 1 on the 24-point semi-quantitative AAC scale. Nocturia was defined as an average of >= 2 voids per night. Three incremental multivariate logistic regression models controlling for (1) age, (2) sex, race, and BMI, and (3) hypertension, diabetes mellitus, and smoking history were used to determine whether nocturia predicted AAC. These models were and modified to exclude age and/or sex to perform age- and/or sex-specific sub-analyses, respectively. Complete data were available from 2,945 participants (29.1% AAC, 31.4% nocturia). On univariate analysis, the association between nocturia and AAC was significant in women (OR 1.77 [95% CI 1.37-2.29], p < 0.001), but not in men (1.14 [0.74-1.76], p = 0.531). Multivariate analysis showed nocturia was an independent predictor of AAC in women in Models I-II (ORs 1.49-1.58, p <= 0.032) but not Model III (1.37 [0.90-2.09], p = 0.133). Stratification by age revealed a strong univariate association among women aged 50-59 (3.88 [1.97-7.61], p < 0.001), which persisted across all multivariate models (ORs 4.05-4.41, p <= 0.001). The presence of nocturia is an important clue of AAC in women, especially those middle-aged.},
  author       = {Khan, Saad Ahmed and Rahman, Ebad U. and Chobufo, Muchi Ditah and Yasin, Aneeq and Monaghan, Thomas and Weiss, Jeffrey and Lazar, Jason M.},
  issn         = {0094-5145},
  journal      = {JOURNAL OF COMMUNITY HEALTH},
  keywords     = {Public Health,Environmental and Occupational Health,Health(social science),AAC,Atherosclerosis,Cardiovascular,Nocturia,CORONARY-ARTERY CALCIUM,ENDOTHELIAL DYSFUNCTION,HEART-DISEASE,RISK,AGE,PROGRESSION,STIFFNESS,MORTALITY,QUALITY},
  language     = {eng},
  pages        = {5},
  title        = {Nocturia is an independent predictor of abdominal aortic calcification in women : results from the National Health and Nutrition Examination Survey},
  url          = {http://dx.doi.org/10.1007/s10900-020-00893-x},
  year         = {2020},
}

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