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Subventricular zone contacting glioblastoma : tumor size, molecular biological factors and patient survival

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Abstract
Background Several studies show that subventricular zone (SVZ) contact of glioblastoma at diagnosis is a negative prognosticator of survival. In this report, we study glioblastoma patient survival, molecular biological and MRI-based volumetric findings according to SVZ contact. Patients and methods We conducted a retrospective study of adult patients diagnosed with supratentorial glioblastoma and uniformly treated with temozolomide-based chemoradiotherapy after surgery. The patient cohort was dichotomized according to tumor contact with the SVZ at diagnosis as determined on preoperative MR imaging. Tumor volume was measured using semi-automated segmentation technique. MGMT-gene promoter methylation and IDH mutation status were determined on stored tumor tissue. Kaplan-Meier survival curves were constructed. Cox regression analysis was used to adjust for known confounding factors of glioblastoma patient survival. Results A total of 214 patients were included in the study of whom 68% belonged to the SVZ(pos)group. Median tumor volume was significantly larger in the SVZ(pos)group (33,8 mL vs 15,6 mL;p < .001). MGMT-unmethylated glioblastoma was more frequent in the SVZ(pos)group (61.4% vs 44.9%;p = .028). The overall survival and progression-free survival were 12.2 months and 5.9 months for the SVZ(pos)patient group but 16.9 months and 10.3 months for the SVZ(neg)group (log-rankp = .016 and .007 respectively). In multivariate Cox survival analysis, SVZ contact proved a negative prognostic parameter, independent from age, KPS, extent of resection, MGMT-methylation and IDH mutation status. Conclusions This study confirms SVZ contact at diagnosis as an independent negative prognostic factor for glioblastoma patient survival. SVZ(pos)glioblastoma had larger tumor size and a larger proportion of unmethylated tumors than SVZ(neg)glioblastoma. Further research is needed to establish whether the observed differences are solely explained by a different molecular profile of SVZ(pos)glioblastoma or by interaction of glioblastoma with the unique SVZ microenvironment.
Keywords
Oncology, Radiology Nuclear Medicine and imaging, Hematology, General Medicine, RADIOTHERAPY, EXTENT

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MLA
Hallaert, Giorgio, et al. “Subventricular Zone Contacting Glioblastoma : Tumor Size, Molecular Biological Factors and Patient Survival.” ACTA ONCOLOGICA, 2020, doi:10.1080/0284186x.2020.1794032.
APA
Hallaert, G., Pinson, H., Van den Broecke, C., Vanhauwaert, D., Van Roost, D., Boterberg, T., & Kalala Okito, J.-P. (2020). Subventricular zone contacting glioblastoma : tumor size, molecular biological factors and patient survival. ACTA ONCOLOGICA. https://doi.org/10.1080/0284186x.2020.1794032
Chicago author-date
Hallaert, Giorgio, Harry Pinson, Caroline Van den Broecke, Dimitri Vanhauwaert, Dirk Van Roost, Tom Boterberg, and Jean-Pierre Kalala Okito. 2020. “Subventricular Zone Contacting Glioblastoma : Tumor Size, Molecular Biological Factors and Patient Survival.” ACTA ONCOLOGICA. https://doi.org/10.1080/0284186x.2020.1794032.
Chicago author-date (all authors)
Hallaert, Giorgio, Harry Pinson, Caroline Van den Broecke, Dimitri Vanhauwaert, Dirk Van Roost, Tom Boterberg, and Jean-Pierre Kalala Okito. 2020. “Subventricular Zone Contacting Glioblastoma : Tumor Size, Molecular Biological Factors and Patient Survival.” ACTA ONCOLOGICA. doi:10.1080/0284186x.2020.1794032.
Vancouver
1.
Hallaert G, Pinson H, Van den Broecke C, Vanhauwaert D, Van Roost D, Boterberg T, et al. Subventricular zone contacting glioblastoma : tumor size, molecular biological factors and patient survival. ACTA ONCOLOGICA. 2020;
IEEE
[1]
G. Hallaert et al., “Subventricular zone contacting glioblastoma : tumor size, molecular biological factors and patient survival,” ACTA ONCOLOGICA, 2020.
@article{8670430,
  abstract     = {Background Several studies show that subventricular zone (SVZ) contact of glioblastoma at diagnosis is a negative prognosticator of survival. In this report, we study glioblastoma patient survival, molecular biological and MRI-based volumetric findings according to SVZ contact. Patients and methods We conducted a retrospective study of adult patients diagnosed with supratentorial glioblastoma and uniformly treated with temozolomide-based chemoradiotherapy after surgery. The patient cohort was dichotomized according to tumor contact with the SVZ at diagnosis as determined on preoperative MR imaging. Tumor volume was measured using semi-automated segmentation technique. MGMT-gene promoter methylation and IDH mutation status were determined on stored tumor tissue. Kaplan-Meier survival curves were constructed. Cox regression analysis was used to adjust for known confounding factors of glioblastoma patient survival. Results A total of 214 patients were included in the study of whom 68% belonged to the SVZ(pos)group. Median tumor volume was significantly larger in the SVZ(pos)group (33,8 mL vs 15,6 mL;p < .001). MGMT-unmethylated glioblastoma was more frequent in the SVZ(pos)group (61.4% vs 44.9%;p = .028). The overall survival and progression-free survival were 12.2 months and 5.9 months for the SVZ(pos)patient group but 16.9 months and 10.3 months for the SVZ(neg)group (log-rankp = .016 and .007 respectively). In multivariate Cox survival analysis, SVZ contact proved a negative prognostic parameter, independent from age, KPS, extent of resection, MGMT-methylation and IDH mutation status. Conclusions This study confirms SVZ contact at diagnosis as an independent negative prognostic factor for glioblastoma patient survival. SVZ(pos)glioblastoma had larger tumor size and a larger proportion of unmethylated tumors than SVZ(neg)glioblastoma. Further research is needed to establish whether the observed differences are solely explained by a different molecular profile of SVZ(pos)glioblastoma or by interaction of glioblastoma with the unique SVZ microenvironment.},
  author       = {Hallaert, Giorgio and Pinson, Harry and Van den Broecke, Caroline and Vanhauwaert, Dimitri and Van Roost, Dirk and Boterberg, Tom and Kalala Okito, Jean-Pierre},
  issn         = {0284-186X},
  journal      = {ACTA ONCOLOGICA},
  keywords     = {Oncology,Radiology Nuclear Medicine and imaging,Hematology,General Medicine,RADIOTHERAPY,EXTENT},
  language     = {eng},
  pages        = {6},
  title        = {Subventricular zone contacting glioblastoma : tumor size, molecular biological factors and patient survival},
  url          = {http://dx.doi.org/10.1080/0284186x.2020.1794032},
  year         = {2020},
}

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