Advanced search
1 file | 1.73 MB Add to list

The role of soluble receptor for advanced glycation end-products (sRAGE) in the general population and patients with diabetes mellitus with a focus on renal function and overall outcome

Mieke Steenbeke (UGent) , Sander De Bruyne (UGent) , Marc De Buyzere (UGent) , Bruno Lapauw (UGent) , Reinhart Speeckaert (UGent) , Mirko Petrovic (UGent) , Joris Delanghe (UGent) and Marijn Speeckaert (UGent)
Author
Organization
Abstract
Isoforms of the receptor for advanced glycation end-product (RAGE) protein, which lack the transmembrane and the signaling (soluble RAGE or sRAGE) domains are hypothesized to counteract the detrimental action of the full-length receptor by acting as a decoy, and they provide a potential tool to treat RAGE-associated diseases. Multiple studies have explored the relationship between sRAGE and endogenous secretory RAGE and its polymorphism and obesity, metabolic syndrome, atherosclerosis, kidney function, and increased mortality in the general population. In addition, sRAGE may be a key player in the pathogenesis of diabetes mellitus and its microvascular (e.g. kidney disease) as well as macrovascular (e.g. cardiovascular disease) complications. In this review, we focus on the role of sRAGE as a biomarker in these specific areas. As there is a lack of an underlying unifying hypothesis about how sRAGE changes according to the disease condition or risk factor, there is a call to incorporate all three players of the AGE-RAGE axis into a new universal biomarker/risk marker: (AGE + RAGE)/sRAGE. However, the measurement of RAGE in humans is not practical as it is a cell-bound receptor for which tissue is required for analysis. A high AGE/sRAGE ratio may be a valuable alternative and practical universal biomarker/risk marker for diseases associated with the AGE-RAGE axis, irrespective of low or high serum sRAGE concentrations.
Keywords
Kidney disease, polymorphism, soluble receptor for advanced glycation endproducts, sRAGE, ENDOGENOUS SECRETORY RECEPTOR, CHRONIC KIDNEY-DISEASE, CARDIOMETABOLIC RISK-FACTORS, SERUM-LEVELS, PLASMA-LEVELS, CAROTID ATHEROSCLEROSIS, CIRCULATING CONCENTRATIONS, CARDIOVASCULAR-DISEASE, RAGE GENE, ENDOTHELIAL DYSFUNCTION

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.73 MB

Citation

Please use this url to cite or link to this publication:

MLA
Steenbeke, Mieke, et al. “The Role of Soluble Receptor for Advanced Glycation End-Products (SRAGE) in the General Population and Patients with Diabetes Mellitus with a Focus on Renal Function and Overall Outcome.” CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2020, doi:10.1080/10408363.2020.1791045.
APA
Steenbeke, M., De Bruyne, S., De Buyzere, M., Lapauw, B., Speeckaert, R., Petrovic, M., … Speeckaert, M. (2020). The role of soluble receptor for advanced glycation end-products (sRAGE) in the general population and patients with diabetes mellitus with a focus on renal function and overall outcome. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. https://doi.org/10.1080/10408363.2020.1791045
Chicago author-date
Steenbeke, Mieke, Sander De Bruyne, Marc De Buyzere, Bruno Lapauw, Reinhart Speeckaert, Mirko Petrovic, Joris Delanghe, and Marijn Speeckaert. 2020. “The Role of Soluble Receptor for Advanced Glycation End-Products (SRAGE) in the General Population and Patients with Diabetes Mellitus with a Focus on Renal Function and Overall Outcome.” CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. https://doi.org/10.1080/10408363.2020.1791045.
Chicago author-date (all authors)
Steenbeke, Mieke, Sander De Bruyne, Marc De Buyzere, Bruno Lapauw, Reinhart Speeckaert, Mirko Petrovic, Joris Delanghe, and Marijn Speeckaert. 2020. “The Role of Soluble Receptor for Advanced Glycation End-Products (SRAGE) in the General Population and Patients with Diabetes Mellitus with a Focus on Renal Function and Overall Outcome.” CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. doi:10.1080/10408363.2020.1791045.
Vancouver
1.
Steenbeke M, De Bruyne S, De Buyzere M, Lapauw B, Speeckaert R, Petrovic M, et al. The role of soluble receptor for advanced glycation end-products (sRAGE) in the general population and patients with diabetes mellitus with a focus on renal function and overall outcome. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. 2020;
IEEE
[1]
M. Steenbeke et al., “The role of soluble receptor for advanced glycation end-products (sRAGE) in the general population and patients with diabetes mellitus with a focus on renal function and overall outcome,” CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2020.
@article{8670273,
  abstract     = {Isoforms of the receptor for advanced glycation end-product (RAGE) protein, which lack the transmembrane and the signaling (soluble RAGE or sRAGE) domains are hypothesized to counteract the detrimental action of the full-length receptor by acting as a decoy, and they provide a potential tool to treat RAGE-associated diseases. Multiple studies have explored the relationship between sRAGE and endogenous secretory RAGE and its polymorphism and obesity, metabolic syndrome, atherosclerosis, kidney function, and increased mortality in the general population. In addition, sRAGE may be a key player in the pathogenesis of diabetes mellitus and its microvascular (e.g. kidney disease) as well as macrovascular (e.g. cardiovascular disease) complications. In this review, we focus on the role of sRAGE as a biomarker in these specific areas. As there is a lack of an underlying unifying hypothesis about how sRAGE changes according to the disease condition or risk factor, there is a call to incorporate all three players of the AGE-RAGE axis into a new universal biomarker/risk marker: (AGE + RAGE)/sRAGE. However, the measurement of RAGE in humans is not practical as it is a cell-bound receptor for which tissue is required for analysis. A high AGE/sRAGE ratio may be a valuable alternative and practical universal biomarker/risk marker for diseases associated with the AGE-RAGE axis, irrespective of low or high serum sRAGE concentrations.},
  author       = {Steenbeke, Mieke and De Bruyne, Sander and De Buyzere, Marc and Lapauw, Bruno and Speeckaert, Reinhart and Petrovic, Mirko and Delanghe, Joris and Speeckaert, Marijn},
  issn         = {1040-8363},
  journal      = {CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES},
  keywords     = {Kidney disease,polymorphism,soluble receptor for advanced glycation endproducts,sRAGE,ENDOGENOUS SECRETORY RECEPTOR,CHRONIC KIDNEY-DISEASE,CARDIOMETABOLIC RISK-FACTORS,SERUM-LEVELS,PLASMA-LEVELS,CAROTID ATHEROSCLEROSIS,CIRCULATING CONCENTRATIONS,CARDIOVASCULAR-DISEASE,RAGE GENE,ENDOTHELIAL DYSFUNCTION},
  language     = {eng},
  pages        = {18},
  title        = {The role of soluble receptor for advanced glycation end-products (sRAGE) in the general population and patients with diabetes mellitus with a focus on renal function and overall outcome},
  url          = {http://dx.doi.org/10.1080/10408363.2020.1791045},
  year         = {2020},
}

Altmetric
View in Altmetric
Web of Science
Times cited: