Advanced search
1 file | 682.56 KB Add to list

Antimicrobial de-escalation in the ICU : from recommendations to level of evidence

(2020) ADVANCES IN THERAPY. 37(7). p.3083-3096
Author
Organization
Abstract
Antimicrobial de-escalation (ADE) is a component of antimicrobial stewardship (AMS) aimed to reduce exposure to broad-spectrum antimicrobials. In the intensive care unit, ADE is a strong recommendation that is moderately applied in clinical practice. Following a systematic review of the literature, we assessed the studies identified on the topic which included one randomized controlled trial and 20 observational studies. The literature shows a low level of evidence, although observational studies suggested that this procedure is safe. The effects of ADE on the level of resistance of ecological systems and especially on the microbiota are unclear. The reviewers recommend de-escalating antimicrobial treatment in patients requiring long-term antibiotic therapy and considering de-escalation in short-term treatments.
Keywords
Pharmacology (medical), General Medicine, Antibiotic, Antimicrobial, Documentation, Infectious disease, Multidrug resistance, Stewardship, VENTILATOR-ASSOCIATED PNEUMONIA, BETA-LACTAM ANTIBIOTICS, CRITICALLY-ILL, SEVERE SEPSIS, THERAPY, CULTURE, METAGENOMICS, EMERGENCE, MORTALITY, IMPACT

Downloads

  • 2020 Lakbar Antimicrobial De-Escalation in the ICU....pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 682.56 KB

Citation

Please use this url to cite or link to this publication:

MLA
Lakbar, Ines, et al. “Antimicrobial De-Escalation in the ICU : From Recommendations to Level of Evidence.” ADVANCES IN THERAPY, vol. 37, no. 7, 2020, pp. 3083–96, doi:10.1007/s12325-020-01390-2.
APA
Lakbar, I., De Waele, J., Tabah, A., Einav, S., Martin-Loeches, I., & Leone, M. (2020). Antimicrobial de-escalation in the ICU : from recommendations to level of evidence. ADVANCES IN THERAPY, 37(7), 3083–3096. https://doi.org/10.1007/s12325-020-01390-2
Chicago author-date
Lakbar, Ines, Jan De Waele, Alexis Tabah, Sharon Einav, Ignacio Martin-Loeches, and Marc Leone. 2020. “Antimicrobial De-Escalation in the ICU : From Recommendations to Level of Evidence.” ADVANCES IN THERAPY 37 (7): 3083–96. https://doi.org/10.1007/s12325-020-01390-2.
Chicago author-date (all authors)
Lakbar, Ines, Jan De Waele, Alexis Tabah, Sharon Einav, Ignacio Martin-Loeches, and Marc Leone. 2020. “Antimicrobial De-Escalation in the ICU : From Recommendations to Level of Evidence.” ADVANCES IN THERAPY 37 (7): 3083–3096. doi:10.1007/s12325-020-01390-2.
Vancouver
1.
Lakbar I, De Waele J, Tabah A, Einav S, Martin-Loeches I, Leone M. Antimicrobial de-escalation in the ICU : from recommendations to level of evidence. ADVANCES IN THERAPY. 2020;37(7):3083–96.
IEEE
[1]
I. Lakbar, J. De Waele, A. Tabah, S. Einav, I. Martin-Loeches, and M. Leone, “Antimicrobial de-escalation in the ICU : from recommendations to level of evidence,” ADVANCES IN THERAPY, vol. 37, no. 7, pp. 3083–3096, 2020.
@article{8669852,
  abstract     = {Antimicrobial de-escalation (ADE) is a component of antimicrobial stewardship (AMS) aimed to reduce exposure to broad-spectrum antimicrobials. In the intensive care unit, ADE is a strong recommendation that is moderately applied in clinical practice. Following a systematic review of the literature, we assessed the studies identified on the topic which included one randomized controlled trial and 20 observational studies. The literature shows a low level of evidence, although observational studies suggested that this procedure is safe. The effects of ADE on the level of resistance of ecological systems and especially on the microbiota are unclear. The reviewers recommend de-escalating antimicrobial treatment in patients requiring long-term antibiotic therapy and considering de-escalation in short-term treatments.},
  author       = {Lakbar, Ines and De Waele, Jan and Tabah, Alexis and Einav, Sharon and Martin-Loeches, Ignacio and Leone, Marc},
  issn         = {0741-238X},
  journal      = {ADVANCES IN THERAPY},
  keywords     = {Pharmacology (medical),General Medicine,Antibiotic,Antimicrobial,Documentation,Infectious disease,Multidrug resistance,Stewardship,VENTILATOR-ASSOCIATED PNEUMONIA,BETA-LACTAM ANTIBIOTICS,CRITICALLY-ILL,SEVERE SEPSIS,THERAPY,CULTURE,METAGENOMICS,EMERGENCE,MORTALITY,IMPACT},
  language     = {eng},
  number       = {7},
  pages        = {3083--3096},
  title        = {Antimicrobial de-escalation in the ICU : from recommendations to level of evidence},
  url          = {http://dx.doi.org/10.1007/s12325-020-01390-2},
  volume       = {37},
  year         = {2020},
}

Altmetric
View in Altmetric
Web of Science
Times cited: