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Abstract
Although an increasing number of beneficial microbiome members are characterized for the human gut and vagina, beneficial microbes are underexplored for the human upper respiratory tract (URT). In this study, we demonstrate that taxa from the beneficial Lactobacillus genus complex are more prevalent in the healthy URT than in patients with chronic rhinosinusitis (CRS). Several URT-specific isolates are cultured, characterized, and further explored for their genetic and functional properties related to adaptation to the URT. Catalase genes are found in the identified lactobacilli, which is a unique feature within this mostly facultative anaerobic genus. Moreover, one of our isolated strains, Lactobacillus casei AMBR2, contains fimbriae that enable strong adherence to URT epithelium, inhibit the growth and virulence of several URT pathogens, and successfully colonize nasal epithelium of healthy volunteers. This study thus demonstrates that specific lactobacilli are adapted to the URT and could have a beneficial keystone function in this habitat.

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MLA
De Boeck, Ilke, et al. “Lactobacilli Have a Niche in the Human Nose.” CELL REPORTS, vol. 31, no. 8, 2020, doi:10.1016/j.celrep.2020.107674.
APA
De Boeck, I., van den Broek, M. F. L., Allonsius, C. N., Spacova, I., Wittouck, S., Martens, K., … Lebeer, S. (2020). Lactobacilli have a niche in the human nose. CELL REPORTS, 31(8). https://doi.org/10.1016/j.celrep.2020.107674
Chicago author-date
De Boeck, Ilke, Marianne F. L. van den Broek, Camille N. Allonsius, Irina Spacova, Stijn Wittouck, Katleen Martens, Sander Wuyts, et al. 2020. “Lactobacilli Have a Niche in the Human Nose.” CELL REPORTS 31 (8). https://doi.org/10.1016/j.celrep.2020.107674.
Chicago author-date (all authors)
De Boeck, Ilke, Marianne F. L. van den Broek, Camille N. Allonsius, Irina Spacova, Stijn Wittouck, Katleen Martens, Sander Wuyts, Eline Cauwenberghs, Katarina Jokicevic, Dieter Vandenheuvel, Tom Eilers, Michelle Lemarcq, Charlotte De Rudder, Sofie Thys, Jean-Pierre Timmermans, Anneclaire V. Vroegop, Alex Verplaetse, Tom Van de Wiele, Filip Kiekens, Peter W. Hellings, Olivier M. Vanderveken, and Sarah Lebeer. 2020. “Lactobacilli Have a Niche in the Human Nose.” CELL REPORTS 31 (8). doi:10.1016/j.celrep.2020.107674.
Vancouver
1.
De Boeck I, van den Broek MFL, Allonsius CN, Spacova I, Wittouck S, Martens K, et al. Lactobacilli have a niche in the human nose. CELL REPORTS. 2020;31(8).
IEEE
[1]
I. De Boeck et al., “Lactobacilli have a niche in the human nose,” CELL REPORTS, vol. 31, no. 8, 2020.
@article{8669723,
  abstract     = {{Although an increasing number of beneficial microbiome members are characterized for the human gut and vagina, beneficial microbes are underexplored for the human upper respiratory tract (URT). In this study, we demonstrate that taxa from the beneficial Lactobacillus genus complex are more prevalent in the healthy URT than in patients with chronic rhinosinusitis (CRS). Several URT-specific isolates are cultured, characterized, and further explored for their genetic and functional properties related to adaptation to the URT. Catalase genes are found in the identified lactobacilli, which is a unique feature within this mostly facultative anaerobic genus. Moreover, one of our isolated strains, Lactobacillus casei AMBR2, contains fimbriae that enable strong adherence to URT epithelium, inhibit the growth and virulence of several URT pathogens, and successfully colonize nasal epithelium of healthy volunteers. This study thus demonstrates that specific lactobacilli are adapted to the URT and could have a beneficial keystone function in this habitat.}},
  articleno    = {{107674}},
  author       = {{De Boeck, Ilke and van den Broek, Marianne F. L. and Allonsius, Camille N. and Spacova, Irina and Wittouck, Stijn and Martens, Katleen and Wuyts, Sander and Cauwenberghs, Eline and Jokicevic, Katarina and Vandenheuvel, Dieter and Eilers, Tom and Lemarcq, Michelle and De Rudder, Charlotte and Thys, Sofie and Timmermans, Jean-Pierre and Vroegop, Anneclaire V. and Verplaetse, Alex and Van de Wiele, Tom and Kiekens, Filip and Hellings, Peter W. and Vanderveken, Olivier M. and Lebeer, Sarah}},
  issn         = {{2211-1247}},
  journal      = {{CELL REPORTS}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{20}},
  title        = {{Lactobacilli have a niche in the human nose}},
  url          = {{http://dx.doi.org/10.1016/j.celrep.2020.107674}},
  volume       = {{31}},
  year         = {{2020}},
}

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