Advanced search
1 file | 461.91 KB Add to list

Toxicokinetics of hydrolyzed fumonisin B1 after single oral or intravenous bolus to broiler chickens fed a control or a fumonisins-contaminated diet

(2020) TOXINS. 12(6).
Author
Organization
Abstract
The toxicokinetics (TK) of hydrolyzed fumonisin B-1(HFB1) were evaluated in 16 broiler chickens after being fed either a control or a fumonisins-contaminated diet (10.8 mg fumonisin B-1, 3.3 mg B(2)and 1.5 mg B-3/kg feed) for two weeks, followed by a single oral (PO) or intravenous (IV) dose of 1.25 mg/kg bodyweight (BW) of HFB1. Fumonisin B-1(FB1), its partially hydrolyzed metabolites pHFB(1a)and pHFB(1b), and fully hydrolyzed metabolite HFB1, were determined in chicken plasma using a validated ultra-performance liquid chromatography-tandem mass spectrometry method. None of the broiler chicken showed clinical symptoms of fumonisins (FBs) or HFB(1)toxicity during the trial, nor was an aberration in body weight observed between the animals fed the FBs-contaminated diet and those fed the control diet. HFB(1)was shown to follow a two-compartmental pharmacokinetic model with first order elimination in broiler chickens after IV administration. Toxicokinetic parameters of HFB(1)demonstrated a total body clearance of 16.39 L/kg center dot h and an intercompartmental flow of 8.34 L/kg center dot h. Low levels of FB(1)and traces of pHFB(1b)were found in plasma of chickens fed the FBs-contaminated diet. Due to plasma concentrations being under the limit of quantification (LOQ) after oral administration of HFB1, no toxicokinetic modelling could be performed in broiler chickens after oral administration of HFB1. Moreover, no phase II metabolites, nor N-acyl-metabolites of HFB(1)could be detected in this study.
Keywords
Toxicology, Health, Toxicology and Mutagenesis, mycotoxins, toxicokinetics, fumonisins metabolites, feeding trial, broiler chicken, MONILIFORME CULTURE MATERIAL, SPHINGOLIPID METABOLISM, FUSARIUM-MYCOTOXINS, CERAMIDE SYNTHASE, IN-VIVO, B-1, TOXICITY, DEOXYNIVALENOL, IDENTIFICATION, B-1-FRUCTOSE

Downloads

  • toxins-12-00413.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 461.91 KB

Citation

Please use this url to cite or link to this publication:

MLA
Antonissen, Gunther, et al. “Toxicokinetics of Hydrolyzed Fumonisin B1 after Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet.” TOXINS, vol. 12, no. 6, 2020, doi:10.3390/toxins12060413.
APA
Antonissen, G., De Baere, S., Novak, B., Schatzmayr, D., den Hollander, D., Devreese, M., & Croubels, S. (2020). Toxicokinetics of hydrolyzed fumonisin B1 after single oral or intravenous bolus to broiler chickens fed a control or a fumonisins-contaminated diet. TOXINS, 12(6). https://doi.org/10.3390/toxins12060413
Chicago author-date
Antonissen, Gunther, Siegrid De Baere, Barbara Novak, Dian Schatzmayr, Danica den Hollander, Mathias Devreese, and Siska Croubels. 2020. “Toxicokinetics of Hydrolyzed Fumonisin B1 after Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet.” TOXINS 12 (6). https://doi.org/10.3390/toxins12060413.
Chicago author-date (all authors)
Antonissen, Gunther, Siegrid De Baere, Barbara Novak, Dian Schatzmayr, Danica den Hollander, Mathias Devreese, and Siska Croubels. 2020. “Toxicokinetics of Hydrolyzed Fumonisin B1 after Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet.” TOXINS 12 (6). doi:10.3390/toxins12060413.
Vancouver
1.
Antonissen G, De Baere S, Novak B, Schatzmayr D, den Hollander D, Devreese M, et al. Toxicokinetics of hydrolyzed fumonisin B1 after single oral or intravenous bolus to broiler chickens fed a control or a fumonisins-contaminated diet. TOXINS. 2020;12(6).
IEEE
[1]
G. Antonissen et al., “Toxicokinetics of hydrolyzed fumonisin B1 after single oral or intravenous bolus to broiler chickens fed a control or a fumonisins-contaminated diet,” TOXINS, vol. 12, no. 6, 2020.
@article{8669159,
  abstract     = {The toxicokinetics (TK) of hydrolyzed fumonisin B-1(HFB1) were evaluated in 16 broiler chickens after being fed either a control or a fumonisins-contaminated diet (10.8 mg fumonisin B-1, 3.3 mg B(2)and 1.5 mg B-3/kg feed) for two weeks, followed by a single oral (PO) or intravenous (IV) dose of 1.25 mg/kg bodyweight (BW) of HFB1. Fumonisin B-1(FB1), its partially hydrolyzed metabolites pHFB(1a)and pHFB(1b), and fully hydrolyzed metabolite HFB1, were determined in chicken plasma using a validated ultra-performance liquid chromatography-tandem mass spectrometry method. None of the broiler chicken showed clinical symptoms of fumonisins (FBs) or HFB(1)toxicity during the trial, nor was an aberration in body weight observed between the animals fed the FBs-contaminated diet and those fed the control diet. HFB(1)was shown to follow a two-compartmental pharmacokinetic model with first order elimination in broiler chickens after IV administration. Toxicokinetic parameters of HFB(1)demonstrated a total body clearance of 16.39 L/kg center dot h and an intercompartmental flow of 8.34 L/kg center dot h. Low levels of FB(1)and traces of pHFB(1b)were found in plasma of chickens fed the FBs-contaminated diet. Due to plasma concentrations being under the limit of quantification (LOQ) after oral administration of HFB1, no toxicokinetic modelling could be performed in broiler chickens after oral administration of HFB1. Moreover, no phase II metabolites, nor N-acyl-metabolites of HFB(1)could be detected in this study.},
  articleno    = {413},
  author       = {Antonissen, Gunther and De Baere, Siegrid and Novak, Barbara and Schatzmayr, Dian and den Hollander, Danica and Devreese, Mathias and Croubels, Siska},
  issn         = {2072-6651},
  journal      = {TOXINS},
  keywords     = {Toxicology,Health,Toxicology and Mutagenesis,mycotoxins,toxicokinetics,fumonisins metabolites,feeding trial,broiler chicken,MONILIFORME CULTURE MATERIAL,SPHINGOLIPID METABOLISM,FUSARIUM-MYCOTOXINS,CERAMIDE SYNTHASE,IN-VIVO,B-1,TOXICITY,DEOXYNIVALENOL,IDENTIFICATION,B-1-FRUCTOSE},
  language     = {eng},
  number       = {6},
  pages        = {13},
  title        = {Toxicokinetics of hydrolyzed fumonisin B1 after single oral or intravenous bolus to broiler chickens fed a control or a fumonisins-contaminated diet},
  url          = {http://dx.doi.org/10.3390/toxins12060413},
  volume       = {12},
  year         = {2020},
}

Altmetric
View in Altmetric
Web of Science
Times cited: