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In-situ X-ray imaging of sublimating spin-frozen solutions

Wannes Goethals (UGent) , Brecht Vanbillemont (UGent) , Joris Lammens (UGent) , Thomas De Beer (UGent) , Chris Vervaet (UGent) and Matthieu Boone (UGent)
(2020) MATERIALS. 13(13).
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Abstract
Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics. In this paper, we describe a methodology to investigate the sublimation front during single unit-dose freeze-drying using 4D in-situ X-ray imaging. Three spin-frozen samples of different solutions were imaged using this methodology and the process characteristics were analysed and reduced to two-dimensional feature maps.
Keywords
X-ray micro-CT, dynamic imaging, in-situ imaging, spin-freezing, freeze-drying, MICRO-CT, HAINES JUMPS, FREEZE, TOMOGRAPHY

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MLA
Goethals, Wannes, et al. “In-Situ X-Ray Imaging of Sublimating Spin-Frozen Solutions.” MATERIALS, vol. 13, no. 13, 2020, doi:10.3390/ma13132953.
APA
Goethals, W., Vanbillemont, B., Lammens, J., De Beer, T., Vervaet, C., & Boone, M. (2020). In-situ X-ray imaging of sublimating spin-frozen solutions. MATERIALS, 13(13). https://doi.org/10.3390/ma13132953
Chicago author-date
Goethals, Wannes, Brecht Vanbillemont, Joris Lammens, Thomas De Beer, Chris Vervaet, and Matthieu Boone. 2020. “In-Situ X-Ray Imaging of Sublimating Spin-Frozen Solutions.” MATERIALS 13 (13). https://doi.org/10.3390/ma13132953.
Chicago author-date (all authors)
Goethals, Wannes, Brecht Vanbillemont, Joris Lammens, Thomas De Beer, Chris Vervaet, and Matthieu Boone. 2020. “In-Situ X-Ray Imaging of Sublimating Spin-Frozen Solutions.” MATERIALS 13 (13). doi:10.3390/ma13132953.
Vancouver
1.
Goethals W, Vanbillemont B, Lammens J, De Beer T, Vervaet C, Boone M. In-situ X-ray imaging of sublimating spin-frozen solutions. MATERIALS. 2020;13(13).
IEEE
[1]
W. Goethals, B. Vanbillemont, J. Lammens, T. De Beer, C. Vervaet, and M. Boone, “In-situ X-ray imaging of sublimating spin-frozen solutions,” MATERIALS, vol. 13, no. 13, 2020.
@article{8668950,
  abstract     = {{Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics. In this paper, we describe a methodology to investigate the sublimation front during single unit-dose freeze-drying using 4D in-situ X-ray imaging. Three spin-frozen samples of different solutions were imaged using this methodology and the process characteristics were analysed and reduced to two-dimensional feature maps.}},
  articleno    = {{2953}},
  author       = {{Goethals, Wannes and Vanbillemont, Brecht and Lammens, Joris and De Beer, Thomas and Vervaet, Chris and Boone, Matthieu}},
  issn         = {{1996-1944}},
  journal      = {{MATERIALS}},
  keywords     = {{X-ray micro-CT,dynamic imaging,in-situ imaging,spin-freezing,freeze-drying,MICRO-CT,HAINES JUMPS,FREEZE,TOMOGRAPHY}},
  language     = {{eng}},
  number       = {{13}},
  pages        = {{16}},
  title        = {{In-situ X-ray imaging of sublimating spin-frozen solutions}},
  url          = {{http://dx.doi.org/10.3390/ma13132953}},
  volume       = {{13}},
  year         = {{2020}},
}

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