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Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women

Selin Bolca UGent, Sam Possemiers UGent, Veerle Maervoet UGent, Inge Huybrechts UGent, Arne Heyerick UGent, Stefaan Vervaecke, Herman Depypere UGent, Denis De Keukeleire UGent, Marc Bracke UGent and Stefaan De Henauw UGent, et al. (2007) BRITISH JOURNAL OF NUTRITION. 98(5). p.950-959
abstract
Hop-derived food supplements and beers contain the prenylflavonoids xanthohumol (X), isoxanthohumol (IX) and the very potent phyto-oestrogen (plant-derived oestrogen mimic) 8-prenylnaringenin (8-PN). The weakly oestrogenic IX can be bioactivated via O-demethylation to 8-PN. Since IX usually predominates over 8-PN, human subjects may be exposed to increased doses of 8-PN. A dietary intervention trial with fifty healthy postmenopausal Caucasian women was under-taken. After a 4 d washout period, participants delivered faeces, blank urine and breath samples. Next, they started a 5 d treatment with hop-based supplements that were administered three times per d and on the last day, a 24 h urine sample was collected. A semi-quantitative FFQ was used to estimate fat, fibre, alcohol, caffeine and theobromine intakes. The recoveries of IX, 8-PN and X in the urine were low and considerable inter-individual variations were observed. A five-fold increase in the dosage of IX without change in 8-PN concentration resulted in a significant lower IX recovery and a higher 8-PN recovery. Classification of the subjects into poor (60 %), moderate (25 %) and strong (15 %) 8-PN producers based on either urinary excretion or microbial bioactivation capacity gave comparable results. Recent antibiotic therapy seemed to affect the 8-PN production negatively. A positive trend between methane excretion and 8-PN production was observed. Strong 8-PN producers consumed less alcohol and had a higher theobromine intake. From this study we conclude that in vivo O-demethylation of IX increases the oestrogenic potency of hop-derived products.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CYP1A2 ACTIVITY, IN-VITRO, METABOLIZING PHENOTYPES, GUT MICROFLORA, PHYTO-ESTROGENS, SOY ISOFLAVONES, POTENT PHYTOESTROGEN, HOPS HUMULUS-LUPULUS, URINARY ISOFLAVONOID EXCRETION, LIVER-MICROSOMES
journal title
BRITISH JOURNAL OF NUTRITION
Br. J. Nutr.
volume
98
issue
5
pages
10 pages
publisher
Cambridge University Press
place of publication
CAMBRIDGE
Web of Science type
Article
Web of Science id
000250752300012
JCR category
NUTRITION & DIETETICS
JCR impact factor
2.339 (2007)
JCR rank
17/56 (2007)
JCR quartile
2 (2007)
ISSN
0007-1145
DOI
10.1017/S0007114507749243
language
English
UGent publication?
yes
classification
A1
id
866863
handle
http://hdl.handle.net/1854/LU-866863
date created
2010-02-18 11:17:03
date last changed
2015-06-17 11:21:50
@article{866863,
  abstract     = {Hop-derived food supplements and beers contain the prenylflavonoids xanthohumol (X), isoxanthohumol (IX) and the very potent phyto-oestrogen (plant-derived oestrogen mimic) 8-prenylnaringenin (8-PN). The weakly oestrogenic IX can be bioactivated via O-demethylation to 8-PN. Since IX usually predominates over 8-PN, human subjects may be exposed to increased doses of 8-PN. A dietary intervention trial with fifty healthy postmenopausal Caucasian women was under-taken. After a 4 d washout period, participants delivered faeces, blank urine and breath samples. Next, they started a 5 d treatment with hop-based supplements that were administered three times per d and on the last day, a 24 h urine sample was collected. A semi-quantitative FFQ was used to estimate fat, fibre, alcohol, caffeine and theobromine intakes. The recoveries of IX, 8-PN and X in the urine were low and considerable inter-individual variations were observed. A five-fold increase in the dosage of IX without change in 8-PN concentration resulted in a significant lower IX recovery and a higher 8-PN recovery. Classification of the subjects into poor (60 \%), moderate (25 \%) and strong (15 \%) 8-PN producers based on either urinary excretion or microbial bioactivation capacity gave comparable results. Recent antibiotic therapy seemed to affect the 8-PN production negatively. A positive trend between methane excretion and 8-PN production was observed. Strong 8-PN producers consumed less alcohol and had a higher theobromine intake. From this study we conclude that in vivo O-demethylation of IX increases the oestrogenic potency of hop-derived products.},
  author       = {Bolca, Selin and Possemiers, Sam and Maervoet, Veerle and Huybrechts, Inge and Heyerick, Arne and Vervaecke, Stefaan and Depypere, Herman and De Keukeleire, Denis and Bracke, Marc and De Henauw, Stefaan and Verstraete, Willy and Van de Wiele, Tom},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keyword      = {CYP1A2 ACTIVITY,IN-VITRO,METABOLIZING PHENOTYPES,GUT MICROFLORA,PHYTO-ESTROGENS,SOY ISOFLAVONES,POTENT PHYTOESTROGEN,HOPS HUMULUS-LUPULUS,URINARY ISOFLAVONOID EXCRETION,LIVER-MICROSOMES},
  language     = {eng},
  number       = {5},
  pages        = {950--959},
  publisher    = {Cambridge University Press},
  title        = {Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women},
  url          = {http://dx.doi.org/10.1017/S0007114507749243},
  volume       = {98},
  year         = {2007},
}

Chicago
Bolca, Selin, Sam Possemiers, Veerle Maervoet, Inge Huybrechts, Arne Heyerick, Stefaan Vervaecke, Herman Depypere, et al. 2007. “Microbial and Dietary Factors Associated with the 8-prenylnaringenin Producer Phenotype: a Dietary Intervention Trial with Fifty Healthy Post-menopausal Caucasian Women.” British Journal of Nutrition 98 (5): 950–959.
APA
Bolca, S., Possemiers, S., Maervoet, V., Huybrechts, I., Heyerick, A., Vervaecke, S., Depypere, H., et al. (2007). Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women. BRITISH JOURNAL OF NUTRITION, 98(5), 950–959.
Vancouver
1.
Bolca S, Possemiers S, Maervoet V, Huybrechts I, Heyerick A, Vervaecke S, et al. Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women. BRITISH JOURNAL OF NUTRITION. CAMBRIDGE: Cambridge University Press; 2007;98(5):950–9.
MLA
Bolca, Selin, Sam Possemiers, Veerle Maervoet, et al. “Microbial and Dietary Factors Associated with the 8-prenylnaringenin Producer Phenotype: a Dietary Intervention Trial with Fifty Healthy Post-menopausal Caucasian Women.” BRITISH JOURNAL OF NUTRITION 98.5 (2007): 950–959. Print.