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Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres

Helene A. Poirel, Marijke Vanspauwen, Gilles Macq, Anke De Geyndt, Johan Maertens, Evelyne Willems, Dominik Selleslag, Xavier Poire, Koen Theunissen, Carlos Graux, et al.
(2019) BONE MARROW TRANSPLANTATION. 54(9). p.1434-1442
Author
Organization
Abstract
While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.
Keywords
BONE-MARROW-TRANSPLANTATION, QUALITY MANAGEMENT-SYSTEM, EUROPEAN-SOCIETY, BLOOD, LEUKEMIA, ECONOMICS, MODELS, CARE, AGE

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MLA
Poirel, Helene A., et al. “Providing Both Autologous and Allogeneic Hematopoietic Stem Cell Transplants (HSCT) May Have a Stronger Impact on the Outcome of Autologous HSCT in Adult Patients than Activity Levels or Implementation of JACIE at Belgian Transplant Centres.” BONE MARROW TRANSPLANTATION, vol. 54, no. 9, Nature Publishing Group, 2019, pp. 1434–42, doi:10.1038/s41409-019-0458-8.
APA
Poirel, H. A., Vanspauwen, M., Macq, G., De Geyndt, A., Maertens, J., Willems, E., … Beguin, Y. (2019). Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. BONE MARROW TRANSPLANTATION, 54(9), 1434–1442. https://doi.org/10.1038/s41409-019-0458-8
Chicago author-date
Poirel, Helene A., Marijke Vanspauwen, Gilles Macq, Anke De Geyndt, Johan Maertens, Evelyne Willems, Dominik Selleslag, et al. 2019. “Providing Both Autologous and Allogeneic Hematopoietic Stem Cell Transplants (HSCT) May Have a Stronger Impact on the Outcome of Autologous HSCT in Adult Patients than Activity Levels or Implementation of JACIE at Belgian Transplant Centres.” BONE MARROW TRANSPLANTATION 54 (9): 1434–42. https://doi.org/10.1038/s41409-019-0458-8.
Chicago author-date (all authors)
Poirel, Helene A., Marijke Vanspauwen, Gilles Macq, Anke De Geyndt, Johan Maertens, Evelyne Willems, Dominik Selleslag, Xavier Poire, Koen Theunissen, Carlos Graux, Tessa Kerre, Pierre Zachee, Nathalie Meuleman, Ann De Becker, Anke Verlinden, Florence Van Obbergh, Christine Schuermans, Virginie De Wilde, Aurelie Jaspers, Delphine Pranger, Dries Deeren, Ivan Van Riet, Evelien Vaes, and Yves Beguin. 2019. “Providing Both Autologous and Allogeneic Hematopoietic Stem Cell Transplants (HSCT) May Have a Stronger Impact on the Outcome of Autologous HSCT in Adult Patients than Activity Levels or Implementation of JACIE at Belgian Transplant Centres.” BONE MARROW TRANSPLANTATION 54 (9): 1434–1442. doi:10.1038/s41409-019-0458-8.
Vancouver
1.
Poirel HA, Vanspauwen M, Macq G, De Geyndt A, Maertens J, Willems E, et al. Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. BONE MARROW TRANSPLANTATION. 2019;54(9):1434–42.
IEEE
[1]
H. A. Poirel et al., “Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres,” BONE MARROW TRANSPLANTATION, vol. 54, no. 9, pp. 1434–1442, 2019.
@article{8668520,
  abstract     = {{While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.}},
  author       = {{Poirel, Helene A. and Vanspauwen, Marijke and Macq, Gilles and De Geyndt, Anke and Maertens, Johan and Willems, Evelyne and Selleslag, Dominik and Poire, Xavier and Theunissen, Koen and Graux, Carlos and Kerre, Tessa and Zachee, Pierre and Meuleman, Nathalie and De Becker, Ann and Verlinden, Anke and Van Obbergh, Florence and Schuermans, Christine and De Wilde, Virginie and Jaspers, Aurelie and Pranger, Delphine and Deeren, Dries and Van Riet, Ivan and Vaes, Evelien and Beguin, Yves}},
  issn         = {{0268-3369}},
  journal      = {{BONE MARROW TRANSPLANTATION}},
  keywords     = {{BONE-MARROW-TRANSPLANTATION,QUALITY MANAGEMENT-SYSTEM,EUROPEAN-SOCIETY,BLOOD,LEUKEMIA,ECONOMICS,MODELS,CARE,AGE}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1434--1442}},
  publisher    = {{Nature Publishing Group}},
  title        = {{Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres}},
  url          = {{http://dx.doi.org/10.1038/s41409-019-0458-8}},
  volume       = {{54}},
  year         = {{2019}},
}
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