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Effects of HF-rTMS over the left and right DLPFC on proactive and reactive cognitive control

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Abstract
Previous research supports the distinction between proactive and reactive control. Although the dorsolateral prefrontal cortex (DLPFC) has been consistently related to these processes, lateralization of proactive and reactive control is still under debate. We manipulated brain activity to investigate the role of the left and right DLPFC in proactive and reactive cognitive control. Using a single-blind, sham-controlled crossover within-subjects design, 25 young healthy females performed the 'AX' Continuous Performance Task after receiving sham vs active high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) to increase left and right DLPFC activity. Reaction times (RTs) and pupillometry were used to assess patterns of proactive and reactive cognitive control and task-related resource allocation, respectively. We observed that, compared to sham, HF-rTMS over the left DLPFC increased proactive control. After right DLPFC HF-rTMS, participants showed slower RTs on AX trials, suggesting more reactive control. However, this latter result was not supported by RTs on BX trials (i.e. the trial that specifically assess reactive control). Pupil measures showed a sustained increase in resource allocation after both active left and right HF-rTMS. Our results with RT data provide evidence on the role of the left DLPFC in proactive control and suggest that the right DLPFC is implicated in reactive control.
Keywords
Experimental and Cognitive Psychology, Cognitive Neuroscience, General Medicine, proactive cognitive control, reactive control, HF-rTMS, neurostimulation, AX-CPT, TRANSCRANIAL MAGNETIC STIMULATION, DORSOLATERAL PREFRONTAL CORTEX, CONTEXT-PROCESSING DEFICITS, GOAL MAINTENANCE, DEPRESSION, TASK, SCHIZOPHRENIA, PERFORMANCE, EXPECTANCY, SESSION

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Citation

Please use this url to cite or link to this publication:

MLA
Pulópulos Tripiana, Matias, et al. “Effects of HF-RTMS over the Left and Right DLPFC on Proactive and Reactive Cognitive Control.” SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, vol. 17, no. 1, 2022, pp. 109–19, doi:10.1093/scan/nsaa082.
APA
Pulópulos Tripiana, M., Allaert, J., Vanderhasselt, M.-A., Sanchez-Lopez, A., De Witte, S., Baeken, C., & De Raedt, R. (2022). Effects of HF-rTMS over the left and right DLPFC on proactive and reactive cognitive control. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 17(1), 109–119. https://doi.org/10.1093/scan/nsaa082
Chicago author-date
Pulópulos Tripiana, Matias, Jens Allaert, Marie-Anne Vanderhasselt, Alvaro Sanchez-Lopez, Sara De Witte, Chris Baeken, and Rudi De Raedt. 2022. “Effects of HF-RTMS over the Left and Right DLPFC on Proactive and Reactive Cognitive Control.” SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 17 (1): 109–19. https://doi.org/10.1093/scan/nsaa082.
Chicago author-date (all authors)
Pulópulos Tripiana, Matias, Jens Allaert, Marie-Anne Vanderhasselt, Alvaro Sanchez-Lopez, Sara De Witte, Chris Baeken, and Rudi De Raedt. 2022. “Effects of HF-RTMS over the Left and Right DLPFC on Proactive and Reactive Cognitive Control.” SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 17 (1): 109–119. doi:10.1093/scan/nsaa082.
Vancouver
1.
Pulópulos Tripiana M, Allaert J, Vanderhasselt M-A, Sanchez-Lopez A, De Witte S, Baeken C, et al. Effects of HF-rTMS over the left and right DLPFC on proactive and reactive cognitive control. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE. 2022;17(1):109–19.
IEEE
[1]
M. Pulópulos Tripiana et al., “Effects of HF-rTMS over the left and right DLPFC on proactive and reactive cognitive control,” SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, vol. 17, no. 1, pp. 109–119, 2022.
@article{8668208,
  abstract     = {{Previous research supports the distinction between proactive and reactive control. Although the dorsolateral prefrontal cortex (DLPFC) has been consistently related to these processes, lateralization of proactive and reactive control is still under debate. We manipulated brain activity to investigate the role of the left and right DLPFC in proactive and reactive cognitive control. Using a single-blind, sham-controlled crossover within-subjects design, 25 young healthy females performed the 'AX' Continuous Performance Task after receiving sham vs active high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) to increase left and right DLPFC activity. Reaction times (RTs) and pupillometry were used to assess patterns of proactive and reactive cognitive control and task-related resource allocation, respectively. We observed that, compared to sham, HF-rTMS over the left DLPFC increased proactive control. After right DLPFC HF-rTMS, participants showed slower RTs on AX trials, suggesting more reactive control. However, this latter result was not supported by RTs on BX trials (i.e. the trial that specifically assess reactive control). Pupil measures showed a sustained increase in resource allocation after both active left and right HF-rTMS. Our results with RT data provide evidence on the role of the left DLPFC in proactive control and suggest that the right DLPFC is implicated in reactive control.}},
  author       = {{Pulópulos Tripiana, Matias and Allaert, Jens and Vanderhasselt, Marie-Anne and Sanchez-Lopez, Alvaro and De Witte, Sara and Baeken, Chris and De Raedt, Rudi}},
  issn         = {{1749-5016}},
  journal      = {{SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE}},
  keywords     = {{Experimental and Cognitive Psychology,Cognitive Neuroscience,General Medicine,proactive cognitive control,reactive control,HF-rTMS,neurostimulation,AX-CPT,TRANSCRANIAL MAGNETIC STIMULATION,DORSOLATERAL PREFRONTAL CORTEX,CONTEXT-PROCESSING DEFICITS,GOAL MAINTENANCE,DEPRESSION,TASK,SCHIZOPHRENIA,PERFORMANCE,EXPECTANCY,SESSION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{109--119}},
  title        = {{Effects of HF-rTMS over the left and right DLPFC on proactive and reactive cognitive control}},
  url          = {{http://dx.doi.org/10.1093/scan/nsaa082}},
  volume       = {{17}},
  year         = {{2022}},
}

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