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Cell-mediated responses to human metapneumovirus infection

Marlies Ballegeer (UGent) and Xavier Saelens (UGent)
(2020) VIRUSES-BASEL. 12(5).
Author
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Abstract
Viruses are the most common cause of acute respiratory tract infections (ARTI). Human metapneumovirus (hMPV) frequently causes viral pneumonia which can become life-threatening if the virus spreads to the lungs. Even though hMPV was only isolated in 2001, this negative-stranded RNA virus has probably been circulating in the human population for many decades. Interestingly, almost all adults have serologic evidence of hMPV infection. A well-established host immune response is evoked when hMPV infection occurs. However, the virus has evolved to circumvent and even exploit the host immune response. Further, infection with hMPV induces a weak memory response, and re-infections during life are common. In this review, we provide a comprehensive overview of the different cell types involved in the immune response in order to better understand the immunopathology induced by hMPV. Such knowledge may contribute to the development of vaccines and therapeutics directed against hMPV.
Keywords
human metapneumovirus, innate and adaptive immune response, evasion strategies, RESPIRATORY SYNCYTIAL VIRUS, CD8(+) T-CELLS, DENDRITIC CELLS, IMMUNE-RESPONSE, PULMONARY INFLAMMATION, ALVEOLAR MACROPHAGES, HUMAN PNEUMOVIRUS, EPITHELIAL-CELLS, TRACT INFECTIONS, LUNG INFECTION

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Citation

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MLA
Ballegeer, Marlies, and Xavier Saelens. “Cell-Mediated Responses to Human Metapneumovirus Infection.” VIRUSES-BASEL, vol. 12, no. 5, 2020, doi:10.3390/v12050542.
APA
Ballegeer, M., & Saelens, X. (2020). Cell-mediated responses to human metapneumovirus infection. VIRUSES-BASEL, 12(5). https://doi.org/10.3390/v12050542
Chicago author-date
Ballegeer, Marlies, and Xavier Saelens. 2020. “Cell-Mediated Responses to Human Metapneumovirus Infection.” VIRUSES-BASEL 12 (5). https://doi.org/10.3390/v12050542.
Chicago author-date (all authors)
Ballegeer, Marlies, and Xavier Saelens. 2020. “Cell-Mediated Responses to Human Metapneumovirus Infection.” VIRUSES-BASEL 12 (5). doi:10.3390/v12050542.
Vancouver
1.
Ballegeer M, Saelens X. Cell-mediated responses to human metapneumovirus infection. VIRUSES-BASEL. 2020;12(5).
IEEE
[1]
M. Ballegeer and X. Saelens, “Cell-mediated responses to human metapneumovirus infection,” VIRUSES-BASEL, vol. 12, no. 5, 2020.
@article{8667942,
  abstract     = {{Viruses are the most common cause of acute respiratory tract infections (ARTI). Human metapneumovirus (hMPV) frequently causes viral pneumonia which can become life-threatening if the virus spreads to the lungs. Even though hMPV was only isolated in 2001, this negative-stranded RNA virus has probably been circulating in the human population for many decades. Interestingly, almost all adults have serologic evidence of hMPV infection. A well-established host immune response is evoked when hMPV infection occurs. However, the virus has evolved to circumvent and even exploit the host immune response. Further, infection with hMPV induces a weak memory response, and re-infections during life are common. In this review, we provide a comprehensive overview of the different cell types involved in the immune response in order to better understand the immunopathology induced by hMPV. Such knowledge may contribute to the development of vaccines and therapeutics directed against hMPV.}},
  articleno    = {{542}},
  author       = {{Ballegeer, Marlies and Saelens, Xavier}},
  issn         = {{1999-4915}},
  journal      = {{VIRUSES-BASEL}},
  keywords     = {{human metapneumovirus,innate and adaptive immune response,evasion strategies,RESPIRATORY SYNCYTIAL VIRUS,CD8(+) T-CELLS,DENDRITIC CELLS,IMMUNE-RESPONSE,PULMONARY INFLAMMATION,ALVEOLAR MACROPHAGES,HUMAN PNEUMOVIRUS,EPITHELIAL-CELLS,TRACT INFECTIONS,LUNG INFECTION}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{22}},
  title        = {{Cell-mediated responses to human metapneumovirus infection}},
  url          = {{http://dx.doi.org/10.3390/v12050542}},
  volume       = {{12}},
  year         = {{2020}},
}

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