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Abstract
Objectives Cannabis allergy has mainly been described following recreational use but some cases also point to cannabis sensitisation as a result of occupational exposure. As a consequence, little is known on the prevalence and clinical phenotype of occupational cannabis allergy. Therefore, this study aims to explore the allergy-associated health risks of occupational cannabis exposure in Belgian police force personnel. Methods 81 participants, active in the police force, reporting regular occupational cannabis exposure during the past 12 months, were included. History was combined with a standardised questionnaire on allergies and cannabis exposure. Basophil activation tests (BAT s) with a crude cannabis extract and rCan s 3 were performed. In addition, specific (s) IgE rCan s 3 as well as sIgE to house dust mite, six pollen and three mould allergens were quantified. Results Although 42% of the participants reported respiratory and/or cutaneous symptoms on occupational cannabis exposure, all cannabis diagnostics were entirely negative, except one symptomatic case demonstrating a borderline result. Furthermore, there is no significant difference between the groups with and without symptoms on cannabis exposure in terms of allergenic sensitisations. Conclusions The origins of the reported respiratory and cutaneous symptoms during cannabis exposure remain elusive but are probably due to non-immune reactions. It should be noted that the study was volunteer-based possibly reflecting an excessive number of symptomatic individuals. Nevertheless, as only one participant reported using fully protective gear, much improvement is needed for reducing the number of symptoms reported on duty, independent of their origin.
Keywords
Public Health, Environmental and Occupational Health, LIPID TRANSFER PROTEIN, CONTACT URTICARIA, HYPERSENSITIVITY REACTIONS, SATIVA, SENSITIZATION, HEMP

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MLA
Decuyper, Ine Ilona, et al. “Occupational Cannabis Exposure and Allergy Risks.” OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol. 76, no. 2, 2019, pp. 78–82, doi:10.1136/oemed-2018-105302.
APA
Decuyper, I. I., Van Gasse, A., Faber, M. A., Mertens, C., Elst, J., Rihs, H.-P., … Ebo, D. (2019). Occupational cannabis exposure and allergy risks. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 76(2), 78–82. https://doi.org/10.1136/oemed-2018-105302
Chicago author-date
Decuyper, Ine Ilona, Athina Van Gasse, Margaretha Antje Faber, Christel Mertens, Jessy Elst, Hans-Peter Rihs, Vito Sabato, et al. 2019. “Occupational Cannabis Exposure and Allergy Risks.” OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 76 (2): 78–82. https://doi.org/10.1136/oemed-2018-105302.
Chicago author-date (all authors)
Decuyper, Ine Ilona, Athina Van Gasse, Margaretha Antje Faber, Christel Mertens, Jessy Elst, Hans-Peter Rihs, Vito Sabato, Hilde Lapeere, Margo Hagendorens, Chris Bridts, Luc De Clerck, and Didier Ebo. 2019. “Occupational Cannabis Exposure and Allergy Risks.” OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 76 (2): 78–82. doi:10.1136/oemed-2018-105302.
Vancouver
1.
Decuyper II, Van Gasse A, Faber MA, Mertens C, Elst J, Rihs H-P, et al. Occupational cannabis exposure and allergy risks. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2019;76(2):78–82.
IEEE
[1]
I. I. Decuyper et al., “Occupational cannabis exposure and allergy risks,” OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol. 76, no. 2, pp. 78–82, 2019.
@article{8667767,
  abstract     = {{Objectives Cannabis allergy has mainly been described following recreational use but some cases also point to cannabis sensitisation as a result of occupational exposure. As a consequence, little is known on the prevalence and clinical phenotype of occupational cannabis allergy. Therefore, this study aims to explore the allergy-associated health risks of occupational cannabis exposure in Belgian police force personnel.

Methods 81 participants, active in the police force, reporting regular occupational cannabis exposure during the past 12 months, were included. History was combined with a standardised questionnaire on allergies and cannabis exposure. Basophil activation tests (BAT s) with a crude cannabis extract and rCan s 3 were performed. In addition, specific (s) IgE rCan s 3 as well as sIgE to house dust mite, six pollen and three mould allergens were quantified.

Results Although 42% of the participants reported respiratory and/or cutaneous symptoms on occupational cannabis exposure, all cannabis diagnostics were entirely negative, except one symptomatic case demonstrating a borderline result. Furthermore, there is no significant difference between the groups with and without symptoms on cannabis exposure in terms of allergenic sensitisations.

Conclusions The origins of the reported respiratory and cutaneous symptoms during cannabis exposure remain elusive but are probably due to non-immune reactions. It should be noted that the study was volunteer-based possibly reflecting an excessive number of symptomatic individuals. Nevertheless, as only one participant reported using fully protective gear, much improvement is needed for reducing the number of symptoms reported on duty, independent of their origin.}},
  author       = {{Decuyper, Ine Ilona and Van Gasse, Athina and Faber, Margaretha Antje and Mertens, Christel and Elst, Jessy and Rihs, Hans-Peter and Sabato, Vito and Lapeere, Hilde and Hagendorens, Margo and Bridts, Chris and De Clerck, Luc and Ebo, Didier}},
  issn         = {{1351-0711}},
  journal      = {{OCCUPATIONAL AND ENVIRONMENTAL MEDICINE}},
  keywords     = {{Public Health,Environmental and Occupational Health,LIPID TRANSFER PROTEIN,CONTACT URTICARIA,HYPERSENSITIVITY REACTIONS,SATIVA,SENSITIZATION,HEMP}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{78--82}},
  title        = {{Occupational cannabis exposure and allergy risks}},
  url          = {{http://dx.doi.org/10.1136/oemed-2018-105302}},
  volume       = {{76}},
  year         = {{2019}},
}

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