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Multiplexed antibody detection with an array of silicon-on-insulator microring resonators

Katrien De Vos (UGent) , Jordi Gironès Molera (UGent) , Tom Claes (UGent) , Yannick De Koninck (UGent) , Stepan Popelka, Etienne Schacht (UGent) , Roel Baets (UGent) and Peter Bienstman (UGent)
(2009) IEEE PHOTONICS JOURNAL. 1(4). p.225-235
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Abstract
Optical cavities are considered promising devices for biosensing to satisfy the high demands of the growing proteomics market. We present a prototype sensor for multiplexed label-free monitoring of biomolecular interactions based on an array of three-by-four silicon-on-insulator microring resonators fabricated by standard complementary metal-oxide semicondutor (CMOS) technology. Parallel readout was performed with an infrared camera. We have demonstrated the simultaneous detection of several model antibodies in a highly specific way. For that, we integrated the optical chip with low-temperature polydimethylsiloxane (PDMS) packaging, enabling excellent compatibility with the receptor molecules. We obtain a very selective biomolecular interaction by grafting a 2.5-nm poly(ethylene glycol) layer to the silicon. Using silicon on insulator as the material platform offers high sensitivity through miniaturization and low-cost mass fabrication through standard CMOS technology steps. The sensors in this interrogation method are able to detect 3.4 pg/mm(2) of a protein overlayer or a theoretical total mass of about 74 ag. For this novel lab on a chip, the fabrication, chemistry, readout, and packaging are developed to be scalable to detect hundreds of affinity interactions within several minutes.
Keywords
biosensors, Silicon nanophotonics, waveguides, INTERFEROMETER, LABEL-FREE DETECTION, REFRACTIVE-INDEX, SENSORS, MICROARRAYS, BIOSENSOR, label-free, resonators, microfluidics

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MLA
De Vos, Katrien, et al. “Multiplexed Antibody Detection with an Array of Silicon-on-Insulator Microring Resonators.” IEEE PHOTONICS JOURNAL, vol. 1, no. 4, 2009, pp. 225–35, doi:10.1109/JPHOT.2009.2035433.
APA
De Vos, K., Gironès Molera, J., Claes, T., De Koninck, Y., Popelka, S., Schacht, E., … Bienstman, P. (2009). Multiplexed antibody detection with an array of silicon-on-insulator microring resonators. IEEE PHOTONICS JOURNAL, 1(4), 225–235. https://doi.org/10.1109/JPHOT.2009.2035433
Chicago author-date
De Vos, Katrien, Jordi Gironès Molera, Tom Claes, Yannick De Koninck, Stepan Popelka, Etienne Schacht, Roel Baets, and Peter Bienstman. 2009. “Multiplexed Antibody Detection with an Array of Silicon-on-Insulator Microring Resonators.” IEEE PHOTONICS JOURNAL 1 (4): 225–35. https://doi.org/10.1109/JPHOT.2009.2035433.
Chicago author-date (all authors)
De Vos, Katrien, Jordi Gironès Molera, Tom Claes, Yannick De Koninck, Stepan Popelka, Etienne Schacht, Roel Baets, and Peter Bienstman. 2009. “Multiplexed Antibody Detection with an Array of Silicon-on-Insulator Microring Resonators.” IEEE PHOTONICS JOURNAL 1 (4): 225–235. doi:10.1109/JPHOT.2009.2035433.
Vancouver
1.
De Vos K, Gironès Molera J, Claes T, De Koninck Y, Popelka S, Schacht E, et al. Multiplexed antibody detection with an array of silicon-on-insulator microring resonators. IEEE PHOTONICS JOURNAL. 2009;1(4):225–35.
IEEE
[1]
K. De Vos et al., “Multiplexed antibody detection with an array of silicon-on-insulator microring resonators,” IEEE PHOTONICS JOURNAL, vol. 1, no. 4, pp. 225–235, 2009.
@article{866750,
  abstract     = {{Optical cavities are considered promising devices for biosensing to satisfy the high demands of the growing proteomics market. We present a prototype sensor for multiplexed label-free monitoring of biomolecular interactions based on an array of three-by-four silicon-on-insulator microring resonators fabricated by standard complementary metal-oxide semicondutor (CMOS) technology. Parallel readout was performed with an infrared camera. We have demonstrated the simultaneous detection of several model antibodies in a highly specific way. For that, we integrated the optical chip with low-temperature polydimethylsiloxane (PDMS) packaging, enabling excellent compatibility with the receptor molecules. We obtain a very selective biomolecular interaction by grafting a 2.5-nm poly(ethylene glycol) layer to the silicon. Using silicon on insulator as the material platform offers high sensitivity through miniaturization and low-cost mass fabrication through standard CMOS technology steps. The sensors in this interrogation method are able to detect 3.4 pg/mm(2) of a protein overlayer or a theoretical total mass of about 74 ag. For this novel lab on a chip, the fabrication, chemistry, readout, and packaging are developed to be scalable to detect hundreds of affinity interactions within several minutes.}},
  author       = {{De Vos, Katrien and Gironès Molera, Jordi and Claes, Tom and De Koninck, Yannick and Popelka, Stepan and Schacht, Etienne and Baets, Roel and Bienstman, Peter}},
  issn         = {{1943-0655}},
  journal      = {{IEEE PHOTONICS JOURNAL}},
  keywords     = {{biosensors,Silicon nanophotonics,waveguides,INTERFEROMETER,LABEL-FREE DETECTION,REFRACTIVE-INDEX,SENSORS,MICROARRAYS,BIOSENSOR,label-free,resonators,microfluidics}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{225--235}},
  title        = {{Multiplexed antibody detection with an array of silicon-on-insulator microring resonators}},
  url          = {{http://doi.org/10.1109/JPHOT.2009.2035433}},
  volume       = {{1}},
  year         = {{2009}},
}
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