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Multiplexed antibody detection with an array of silicon-on-insulator microring resonators

Katrien De Vos UGent, Jordi Gironès Molera UGent, Tom Claes UGent, Yannick De Koninck UGent, Stepan Popelka, Etienne Schacht UGent, Roel Baets UGent and Peter Bienstman UGent (2009) IEEE PHOTONICS JOURNAL. 1(4). p.225-235
abstract
Optical cavities are considered promising devices for biosensing to satisfy the high demands of the growing proteomics market. We present a prototype sensor for multiplexed label-free monitoring of biomolecular interactions based on an array of three-by-four silicon-on-insulator microring resonators fabricated by standard complementary metal-oxide semicondutor (CMOS) technology. Parallel readout was performed with an infrared camera. We have demonstrated the simultaneous detection of several model antibodies in a highly specific way. For that, we integrated the optical chip with low-temperature polydimethylsiloxane (PDMS) packaging, enabling excellent compatibility with the receptor molecules. We obtain a very selective biomolecular interaction by grafting a 2.5-nm poly(ethylene glycol) layer to the silicon. Using silicon on insulator as the material platform offers high sensitivity through miniaturization and low-cost mass fabrication through standard CMOS technology steps. The sensors in this interrogation method are able to detect 3.4 pg/mm(2) of a protein overlayer or a theoretical total mass of about 74 ag. For this novel lab on a chip, the fabrication, chemistry, readout, and packaging are developed to be scalable to detect hundreds of affinity interactions within several minutes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
biosensors, Silicon nanophotonics, waveguides, INTERFEROMETER, LABEL-FREE DETECTION, REFRACTIVE-INDEX, SENSORS, MICROARRAYS, BIOSENSOR, label-free, resonators, microfluidics
journal title
IEEE PHOTONICS JOURNAL
IEEE Photonics J.
volume
1
issue
4
pages
225 - 235
Web of Science type
Article
Web of Science id
000285053500001
ISSN
1943-0655
DOI
10.1109/JPHOT.2009.2035433
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
866750
handle
http://hdl.handle.net/1854/LU-866750
date created
2010-02-18 10:32:47
date last changed
2014-02-25 12:28:56
@article{866750,
  abstract     = {Optical cavities are considered promising devices for biosensing to satisfy the high demands of the growing proteomics market. We present a prototype sensor for multiplexed label-free monitoring of biomolecular interactions based on an array of three-by-four silicon-on-insulator microring resonators fabricated by standard complementary metal-oxide semicondutor (CMOS) technology. Parallel readout was performed with an infrared camera. We have demonstrated the simultaneous detection of several model antibodies in a highly specific way. For that, we integrated the optical chip with low-temperature polydimethylsiloxane (PDMS) packaging, enabling excellent compatibility with the receptor molecules. We obtain a very selective biomolecular interaction by grafting a 2.5-nm poly(ethylene glycol) layer to the silicon. Using silicon on insulator as the material platform offers high sensitivity through miniaturization and low-cost mass fabrication through standard CMOS technology steps. The sensors in this interrogation method are able to detect 3.4 pg/mm(2) of a protein overlayer or a theoretical total mass of about 74 ag. For this novel lab on a chip, the fabrication, chemistry, readout, and packaging are developed to be scalable to detect hundreds of affinity interactions within several minutes.},
  author       = {De Vos, Katrien and Giron{\`e}s Molera, Jordi and Claes, Tom and De Koninck, Yannick and Popelka, Stepan and Schacht, Etienne and Baets, Roel and Bienstman, Peter},
  issn         = {1943-0655},
  journal      = {IEEE PHOTONICS JOURNAL},
  keyword      = {biosensors,Silicon nanophotonics,waveguides,INTERFEROMETER,LABEL-FREE DETECTION,REFRACTIVE-INDEX,SENSORS,MICROARRAYS,BIOSENSOR,label-free,resonators,microfluidics},
  language     = {eng},
  number       = {4},
  pages        = {225--235},
  title        = {Multiplexed antibody detection with an array of silicon-on-insulator microring resonators},
  url          = {http://dx.doi.org/10.1109/JPHOT.2009.2035433},
  volume       = {1},
  year         = {2009},
}

Chicago
De Vos, Katrien, Jordi Gironès Molera, Tom Claes, Yannick De Koninck, Stepan Popelka, Etienne Schacht, Roel Baets, and Peter Bienstman. 2009. “Multiplexed Antibody Detection with an Array of Silicon-on-insulator Microring Resonators.” Ieee Photonics Journal 1 (4): 225–235.
APA
De Vos, Katrien, Gironès Molera, J., Claes, T., De Koninck, Y., Popelka, S., Schacht, E., Baets, R., et al. (2009). Multiplexed antibody detection with an array of silicon-on-insulator microring resonators. IEEE PHOTONICS JOURNAL, 1(4), 225–235.
Vancouver
1.
De Vos K, Gironès Molera J, Claes T, De Koninck Y, Popelka S, Schacht E, et al. Multiplexed antibody detection with an array of silicon-on-insulator microring resonators. IEEE PHOTONICS JOURNAL. 2009;1(4):225–35.
MLA
De Vos, Katrien, Jordi Gironès Molera, Tom Claes, et al. “Multiplexed Antibody Detection with an Array of Silicon-on-insulator Microring Resonators.” IEEE PHOTONICS JOURNAL 1.4 (2009): 225–235. Print.