Advanced search
Add to list

Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls : a case–control study

(2020) PAIN MEDICINE. 21(10). p.2553-2563
Author
Organization
Abstract
Objective. Laser-evoked potentials (LEPs) are among the reliable neurophysiological tools to investigate patients with neuropathic pain, as they can provide an objective account of the functional status of thermo-nociceptive pathways. The goal of this study was to explore the functioning of the nociceptive afferent pathways by examining LEPs in patients with chronic whiplash-associated disorders (cWAD), patients with chronic fatigue syndrome (CFS), and healthy controls (HCs). Design. Case-control study. Setting. A single medical center in Belgium. Subjects. The LEPs of 21 patients with cWAD, 19 patients with CFS, and 18 HCs were analyzed in this study. Methods. All participants received brief nociceptive CO2 laser stimuli applied to the dorsum of the left hand and left foot while brain activity was recorded with a 32-channel electroencephalogram (EEG). LEP signals and transient power modulations were compared between patient groups and HCs. Results. No between-group differences were found for stimulus intensity, which was supraliminal for A delta fibers. The amplitudes and latencies of LEP wave components N1, N2, and P2 in patients with cWAD and CFS were statistically similar to those of HCs. There were no significant differences between the time-frequency maps of EEG oscillation amplitude between HCs and both patient populations. Conclusions. EEG responses of heat-sensitive A delta fibers in patients with cWAD and CFS revealed no significant differences from the responses of HCs. These findings thus do not support a state of generalized central nervous system hyperexcitability in those patients.
Keywords
Anesthesiology and Pain Medicine, Clinical Neurology, General Medicine, Chronic Pain, Electroencephalography, Laser-Evoked Potentials, Central Hyperexcitability, PAIN CATASTROPHIZING SCALE, CENTRAL SENSITIZATION, CENTRAL HYPERSENSITIVITY, CLINICAL-USEFULNESS, DISABILITY INDEX, HEAT PAIN, STIMULATION, VALIDATION, MODULATION, HABITUATION

Citation

Please use this url to cite or link to this publication:

MLA
Goudman, Lisa, et al. “Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and Healthy Controls : A Case–Control Study.” PAIN MEDICINE, vol. 21, no. 10, 2020, pp. 2553–63, doi:10.1093/pm/pnaa068.
APA
Goudman, L., Daenen, L., Mouraux, A., Nijs, J., Cras, P., Roussel, N., … De Kooning, M. (2020). Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls : a case–control study. PAIN MEDICINE, 21(10), 2553–2563. https://doi.org/10.1093/pm/pnaa068
Chicago author-date
Goudman, Lisa, Liesbeth Daenen, Andre Mouraux, Jo Nijs, Patrick Cras, Nathalie Roussel, Maarten Moens, Iris Coppieters, Eva Huysmans, and Margot De Kooning. 2020. “Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and Healthy Controls : A Case–Control Study.” PAIN MEDICINE 21 (10): 2553–63. https://doi.org/10.1093/pm/pnaa068.
Chicago author-date (all authors)
Goudman, Lisa, Liesbeth Daenen, Andre Mouraux, Jo Nijs, Patrick Cras, Nathalie Roussel, Maarten Moens, Iris Coppieters, Eva Huysmans, and Margot De Kooning. 2020. “Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and Healthy Controls : A Case–Control Study.” PAIN MEDICINE 21 (10): 2553–2563. doi:10.1093/pm/pnaa068.
Vancouver
1.
Goudman L, Daenen L, Mouraux A, Nijs J, Cras P, Roussel N, et al. Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls : a case–control study. PAIN MEDICINE. 2020;21(10):2553–63.
IEEE
[1]
L. Goudman et al., “Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls : a case–control study,” PAIN MEDICINE, vol. 21, no. 10, pp. 2553–2563, 2020.
@article{8667335,
  abstract     = {{Objective. Laser-evoked potentials (LEPs) are among the reliable neurophysiological tools to investigate patients with neuropathic pain, as they can provide an objective account of the functional status of thermo-nociceptive pathways. The goal of this study was to explore the functioning of the nociceptive afferent pathways by examining LEPs in patients with chronic whiplash-associated disorders (cWAD), patients with chronic fatigue syndrome (CFS), and healthy controls (HCs). Design. Case-control study. Setting. A single medical center in Belgium. Subjects. The LEPs of 21 patients with cWAD, 19 patients with CFS, and 18 HCs were analyzed in this study. Methods. All participants received brief nociceptive CO2 laser stimuli applied to the dorsum of the left hand and left foot while brain activity was recorded with a 32-channel electroencephalogram (EEG). LEP signals and transient power modulations were compared between patient groups and HCs. Results. No between-group differences were found for stimulus intensity, which was supraliminal for A delta fibers. The amplitudes and latencies of LEP wave components N1, N2, and P2 in patients with cWAD and CFS were statistically similar to those of HCs. There were no significant differences between the time-frequency maps of EEG oscillation amplitude between HCs and both patient populations. Conclusions. EEG responses of heat-sensitive A delta fibers in patients with cWAD and CFS revealed no significant differences from the responses of HCs. These findings thus do not support a state of generalized central nervous system hyperexcitability in those patients.}},
  author       = {{Goudman, Lisa and Daenen, Liesbeth and Mouraux, Andre and Nijs, Jo and Cras, Patrick and Roussel, Nathalie and Moens, Maarten and Coppieters, Iris and Huysmans, Eva and De Kooning, Margot}},
  issn         = {{1526-2375}},
  journal      = {{PAIN MEDICINE}},
  keywords     = {{Anesthesiology and Pain Medicine,Clinical Neurology,General Medicine,Chronic Pain,Electroencephalography,Laser-Evoked Potentials,Central Hyperexcitability,PAIN CATASTROPHIZING SCALE,CENTRAL SENSITIZATION,CENTRAL HYPERSENSITIVITY,CLINICAL-USEFULNESS,DISABILITY INDEX,HEAT PAIN,STIMULATION,VALIDATION,MODULATION,HABITUATION}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2553--2563}},
  title        = {{Processing of laser-evoked potentials in patients with chronic whiplash-associated disorders, chronic fatigue syndrome, and healthy controls : a case–control study}},
  url          = {{http://dx.doi.org/10.1093/pm/pnaa068}},
  volume       = {{21}},
  year         = {{2020}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: