Advanced search
1 file | 866.66 KB Add to list

Exposure assessment of Portuguese population to multiple mycotoxins : the human biomonitoring approach

Author
Organization
Abstract
Mycotoxins constitute a relevant group of food contaminants with several associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring studies have been globally developed to assess the exposure to mycotoxins at individual level. In order to overcome this lack of data, the present study concerned the analysis of mycotoxins in 24h urine and first-morning urine paired samples from 94 participants enrolled within the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016). Following a salt-assisted matrix extraction, urine samples were analysed by liquid chromatography-mass spectrometry for the simultaneous determination of 37 urinary mycotoxins' biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B-1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. Alternariol was identified for the first time in urine samples from a European country; however, risk characterization was not performed due to lack of reference intake value. These results confirmed mycotoxins as part of the human exposome of the Portuguese population reinforcing the need for further studies regarding the determinants of exposure.
Keywords
RISK-ASSESSMENT, OCHRATOXIN-A, DEOXYNIVALENOL EXPOSURE, URINARY, DEOXYNIVALENOL, LIQUID-CHROMATOGRAPHY, FUMONISIN B-1, METABOLITES, BIOMARKER, CEREALS, VALIDATION, Human biomonitoring, Mycotoxins, Biomarkers of exposure, Portugal, Risk, assessment

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 866.66 KB

Citation

Please use this url to cite or link to this publication:

MLA
Martins, C., et al. “Exposure Assessment of Portuguese Population to Multiple Mycotoxins : The Human Biomonitoring Approach.” INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, vol. 222, no. 6, 2019, pp. 913–25, doi:10.1016/j.ijheh.2019.06.010.
APA
Martins, C., Vidal Corominas, A., De Boevre, M., De Saeger, S., Nunes, C., Torres, D., … Alvito, P. (2019). Exposure assessment of Portuguese population to multiple mycotoxins : the human biomonitoring approach. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 222(6), 913–925. https://doi.org/10.1016/j.ijheh.2019.06.010
Chicago author-date
Martins, C., Arnau Vidal Corominas, Marthe De Boevre, Sarah De Saeger, C. Nunes, D. Torres, A. Goios, C. Lopes, R. Assuncao, and P. Alvito. 2019. “Exposure Assessment of Portuguese Population to Multiple Mycotoxins : The Human Biomonitoring Approach.” INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 222 (6): 913–25. https://doi.org/10.1016/j.ijheh.2019.06.010.
Chicago author-date (all authors)
Martins, C., Arnau Vidal Corominas, Marthe De Boevre, Sarah De Saeger, C. Nunes, D. Torres, A. Goios, C. Lopes, R. Assuncao, and P. Alvito. 2019. “Exposure Assessment of Portuguese Population to Multiple Mycotoxins : The Human Biomonitoring Approach.” INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 222 (6): 913–925. doi:10.1016/j.ijheh.2019.06.010.
Vancouver
1.
Martins C, Vidal Corominas A, De Boevre M, De Saeger S, Nunes C, Torres D, et al. Exposure assessment of Portuguese population to multiple mycotoxins : the human biomonitoring approach. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH. 2019;222(6):913–25.
IEEE
[1]
C. Martins et al., “Exposure assessment of Portuguese population to multiple mycotoxins : the human biomonitoring approach,” INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, vol. 222, no. 6, pp. 913–925, 2019.
@article{8667229,
  abstract     = {Mycotoxins constitute a relevant group of food contaminants with several associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring studies have been globally developed to assess the exposure to mycotoxins at individual level. In order to overcome this lack of data, the present study concerned the analysis of mycotoxins in 24h urine and first-morning urine paired samples from 94 participants enrolled within the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016). Following a salt-assisted matrix extraction, urine samples were analysed by liquid chromatography-mass spectrometry for the simultaneous determination of 37 urinary mycotoxins' biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B-1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. Alternariol was identified for the first time in urine samples from a European country; however, risk characterization was not performed due to lack of reference intake value. These results confirmed mycotoxins as part of the human exposome of the Portuguese population reinforcing the need for further studies regarding the determinants of exposure.},
  author       = {Martins, C. and Vidal Corominas, Arnau and De Boevre, Marthe and De Saeger, Sarah and Nunes, C. and Torres, D. and Goios, A. and Lopes, C. and Assuncao, R. and Alvito, P.},
  issn         = {1438-4639},
  journal      = {INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH},
  keywords     = {RISK-ASSESSMENT,OCHRATOXIN-A,DEOXYNIVALENOL EXPOSURE,URINARY,DEOXYNIVALENOL,LIQUID-CHROMATOGRAPHY,FUMONISIN B-1,METABOLITES,BIOMARKER,CEREALS,VALIDATION,Human biomonitoring,Mycotoxins,Biomarkers of exposure,Portugal,Risk,assessment},
  language     = {eng},
  number       = {6},
  pages        = {913--925},
  title        = {Exposure assessment of Portuguese population to multiple mycotoxins : the human biomonitoring approach},
  url          = {http://dx.doi.org/10.1016/j.ijheh.2019.06.010},
  volume       = {222},
  year         = {2019},
}

Altmetric
View in Altmetric
Web of Science
Times cited: