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Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer

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Abstract
Intra-abdominal dissemination of peritoneal nodules, a condition known as peritoneal carcinomatosis (PC), is typically diagnosed in ovarian cancer patients at the advanced stages. The current treatment of PC consists of perioperative systemic chemotherapy and cytoreductive surgery, followed by intra-abdominal flushing with solutions of chemotherapeutics such as cisplatin and oxaliplatin. In this study, we developed cisplatin-loaded polyarginine-hyaluronic acid nanoscale particles (Cis-pARG-HA NPs) with high colloidal stability, marked drug loading efficiency, unimpaired biological activity, and tumor-targeting ability. Injected Cis-pARG-HA NPs showed enhanced antitumor activity in a rat model of PC, compared to injection of the free cisplatin drug. The activity of Cis-pARG-HA NPs could even be further improved when administered by an intra-abdominal aerosol therapy, referred to as pressurized intraperitoneal aerosol chemotherapy (PIPAC). PIPAC is hypothesized to ensure a more homogeneous drug distribution together with a deeper drug penetration into peritoneal tumor nodules within the abdominal cavity. Using fluorescent pARG-HA NPs, this enhanced nanoparticle deposit on tumors could indeed be observed in regions opposite the aerosolization nozzle. Therefore, this study demonstrates that nanoparticles carrying chemotherapeutics can be synergistically combined with the PIPAC technique for IP therapy of disseminated advanced ovarian tumors, while this synergistic effect was not observed for the administration of free cisplatin.
Keywords
General Materials Science, nanomedicine, cisplatin, hyaluronic acid, polyarginine, peritoneal carcinomatosis, PIPAC, aerosolization, intraperitoneal drug delivery

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MLA
Shariati, Molood, et al. “Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine : Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer.” ACS APPLIED MATERIALS & INTERFACES, 2020, doi:10.1021/acsami.0c05554.
APA
Shariati, M., Lollo, G., Matha, K., Descamps, B., Vanhove, C., Van de Sande, L., … Remaut, K. (2020). Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer. ACS APPLIED MATERIALS & INTERFACES. https://doi.org/10.1021/acsami.0c05554
Chicago author-date
Shariati, Molood, Giovanna Lollo, Kevin Matha, Benedicte Descamps, Christian Vanhove, Leen Van de Sande, Wouter Willaert, et al. 2020. “Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine : Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer.” ACS APPLIED MATERIALS & INTERFACES. https://doi.org/10.1021/acsami.0c05554.
Chicago author-date (all authors)
Shariati, Molood, Giovanna Lollo, Kevin Matha, Benedicte Descamps, Christian Vanhove, Leen Van de Sande, Wouter Willaert, Lieve Balcaen, Frank Vanhaecke, Jean-Pierre Benoit, Wim Ceelen, Stefaan De Smedt, and Katrien Remaut. 2020. “Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine : Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer.” ACS APPLIED MATERIALS & INTERFACES. doi:10.1021/acsami.0c05554.
Vancouver
1.
Shariati M, Lollo G, Matha K, Descamps B, Vanhove C, Van de Sande L, et al. Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer. ACS APPLIED MATERIALS & INTERFACES. 2020;
IEEE
[1]
M. Shariati et al., “Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer,” ACS APPLIED MATERIALS & INTERFACES, 2020.
@article{8667075,
  abstract     = {Intra-abdominal dissemination of peritoneal nodules, a condition known as peritoneal carcinomatosis (PC), is typically diagnosed in ovarian cancer patients at the advanced stages. The current treatment of PC consists of perioperative systemic chemotherapy and cytoreductive surgery, followed by intra-abdominal flushing with solutions of chemotherapeutics such as cisplatin and oxaliplatin. In this study, we developed cisplatin-loaded polyarginine-hyaluronic acid nanoscale particles (Cis-pARG-HA NPs) with high colloidal stability, marked drug loading efficiency, unimpaired biological activity, and tumor-targeting ability. Injected Cis-pARG-HA NPs showed enhanced antitumor activity in a rat model of PC, compared to injection of the free cisplatin drug. The activity of Cis-pARG-HA NPs could even be further improved when administered by an intra-abdominal aerosol therapy, referred to as pressurized intraperitoneal aerosol chemotherapy (PIPAC). PIPAC is hypothesized to ensure a more homogeneous drug distribution together with a deeper drug penetration into peritoneal tumor nodules within the abdominal cavity. Using fluorescent pARG-HA NPs, this enhanced nanoparticle deposit on tumors could indeed be observed in regions opposite the aerosolization nozzle. Therefore, this study demonstrates that nanoparticles carrying chemotherapeutics can be synergistically combined with the PIPAC technique for IP therapy of disseminated advanced ovarian tumors, while this synergistic effect was not observed for the administration of free cisplatin.},
  author       = {Shariati, Molood and Lollo, Giovanna and Matha, Kevin and Descamps, Benedicte and Vanhove, Christian and Van de Sande, Leen and Willaert, Wouter and Balcaen, Lieve and Vanhaecke, Frank and Benoit, Jean-Pierre and Ceelen, Wim and De Smedt, Stefaan and Remaut, Katrien},
  issn         = {1944-8244},
  journal      = {ACS APPLIED MATERIALS & INTERFACES},
  keywords     = {General Materials Science,nanomedicine,cisplatin,hyaluronic acid,polyarginine,peritoneal carcinomatosis,PIPAC,aerosolization,intraperitoneal drug delivery},
  language     = {eng},
  pages        = {13},
  title        = {Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer},
  url          = {http://dx.doi.org/10.1021/acsami.0c05554},
  year         = {2020},
}

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