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Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)

Maarten Vergaelen (UGent) , Bart Verbraeken (UGent) , Joachim Van Guyse (UGent) , Annelore Podevyn (UGent) , Ali Tigrine (UGent) , Victor Retamero De La Rosa (UGent) , Bryn Monnery (UGent) and Richard Hoogenboom (UGent)
(2020) GREEN CHEMISTRY. 22(5). p.1747-1753
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Abstract
Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this article, we report the polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace the current state-of-the-art polymerization of EtOx in acetonitrile and chlorobenzene. This switch towards ethyl acetate as green solvent is an important improvement towards pharmaceutical compliance/compatibility, besides the lower burden for the environment.
Keywords
RING-OPENING POLYMERIZATION, CYCLIC IMINO ETHERS, IN-VITRO, GENE, DELIVERY, 2-ETHYL-2-OXAZOLINE, POLY(2-OXAZOLINE)S, IMINOETHERS, CHEMISTRY, FILMS, PEI

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MLA
Vergaelen, Maarten, et al. “Ethyl Acetate as Solvent for the Synthesis of Poly(2-Ethyl-2-Oxazoline).” GREEN CHEMISTRY, vol. 22, no. 5, 2020, pp. 1747–53, doi:10.1039/c9gc03872h.
APA
Vergaelen, M., Verbraeken, B., Van Guyse, J., Podevyn, A., Tigrine, A., Retamero De La Rosa, V., … Hoogenboom, R. (2020). Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline). GREEN CHEMISTRY, 22(5), 1747–1753. https://doi.org/10.1039/c9gc03872h
Chicago author-date
Vergaelen, Maarten, Bart Verbraeken, Joachim Van Guyse, Annelore Podevyn, Ali Tigrine, Victor Retamero De La Rosa, Bryn Monnery, and Richard Hoogenboom. 2020. “Ethyl Acetate as Solvent for the Synthesis of Poly(2-Ethyl-2-Oxazoline).” GREEN CHEMISTRY 22 (5): 1747–53. https://doi.org/10.1039/c9gc03872h.
Chicago author-date (all authors)
Vergaelen, Maarten, Bart Verbraeken, Joachim Van Guyse, Annelore Podevyn, Ali Tigrine, Victor Retamero De La Rosa, Bryn Monnery, and Richard Hoogenboom. 2020. “Ethyl Acetate as Solvent for the Synthesis of Poly(2-Ethyl-2-Oxazoline).” GREEN CHEMISTRY 22 (5): 1747–1753. doi:10.1039/c9gc03872h.
Vancouver
1.
Vergaelen M, Verbraeken B, Van Guyse J, Podevyn A, Tigrine A, Retamero De La Rosa V, et al. Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline). GREEN CHEMISTRY. 2020;22(5):1747–53.
IEEE
[1]
M. Vergaelen et al., “Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline),” GREEN CHEMISTRY, vol. 22, no. 5, pp. 1747–1753, 2020.
@article{8666915,
  abstract     = {Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this article, we report the polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace the current state-of-the-art polymerization of EtOx in acetonitrile and chlorobenzene. This switch towards ethyl acetate as green solvent is an important improvement towards pharmaceutical compliance/compatibility, besides the lower burden for the environment.},
  author       = {Vergaelen, Maarten and Verbraeken, Bart and Van Guyse, Joachim and Podevyn, Annelore and Tigrine, Ali and Retamero De La Rosa, Victor and Monnery, Bryn and Hoogenboom, Richard},
  issn         = {1463-9262},
  journal      = {GREEN CHEMISTRY},
  keywords     = {RING-OPENING POLYMERIZATION,CYCLIC IMINO ETHERS,IN-VITRO,GENE,DELIVERY,2-ETHYL-2-OXAZOLINE,POLY(2-OXAZOLINE)S,IMINOETHERS,CHEMISTRY,FILMS,PEI},
  language     = {eng},
  number       = {5},
  pages        = {1747--1753},
  title        = {Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)},
  url          = {http://dx.doi.org/10.1039/c9gc03872h},
  volume       = {22},
  year         = {2020},
}

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