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Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation

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Abstract
There is an increasing interest in intraperitoneal delivery of chemotherapy as an aerosol in patients with peritoneal metastasis. The currently used technology is hampered by inhomogenous drug delivery throughout the peritoneal cavity because of gravity, drag, and inertial impaction. Addition of an electrical force to aerosol particles, exerted by an electrostatic field, can improve spatial aerosol homogeneity and enhance tissue penetration. A computational fluid dynamics model shows that electrostatic precipitation (EP) results in a significantly improved aerosol distribution. Fluorescent nanoparticles (NPs) remain stable after nebulization in vitro, while EP significantly improves spatial homogeneity of NP distribution. Next, pressurized intraperitoneal chemotherapy with and without EP using NP albumin bound paclitaxel (Nab-PTX) in a novel rat model is examined. EP does not worsen the effects of CO(2)insufflation and intraperitoneal Nab-PTX on mesothelial structural integrity or the severity of peritoneal inflammation. Importantly, EP significantly enhances tissue penetration of Nab-PTX in the anatomical regions not facing the nozzle of the nebulizer. Also, the addition of EP leads to more homogenous peritoneal tissue concentrations of Nab-PTX, in parallel with higher plasma concentrations. In conclusion, EP enhances spatial homogeneity and tissue uptake after intraperitoneal nebulization of anticancer NPs.
Keywords
computational fluid dynamics, electromotive drug administration, electrostatic precipitation, intraperitoneal drug delivery, PIPAC

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MLA
Van de Sande, Leen, et al. “Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles : Proof of Concept and Preclinical Validation.” ADVANCED HEALTHCARE MATERIALS, vol. 9, no. 16, 2020, doi:10.1002/adhm.202000655.
APA
Van de Sande, L., Rahimi Gorji, M., Giordano, S., Davoli, E., Matteo, C., Detlefsen, S., … Ceelen, W. (2020). Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation. ADVANCED HEALTHCARE MATERIALS, 9(16). https://doi.org/10.1002/adhm.202000655
Chicago author-date
Van de Sande, Leen, Mohammad Rahimi Gorji, Silvia Giordano, Enrico Davoli, Cristina Matteo, Sonke Detlefsen, Katharina D’Herde, et al. 2020. “Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles : Proof of Concept and Preclinical Validation.” ADVANCED HEALTHCARE MATERIALS 9 (16). https://doi.org/10.1002/adhm.202000655.
Chicago author-date (all authors)
Van de Sande, Leen, Mohammad Rahimi Gorji, Silvia Giordano, Enrico Davoli, Cristina Matteo, Sonke Detlefsen, Katharina D’Herde, Helena Braet, Molood Shariati, Katrien Remaut, Fei Xie, Charlotte Debbaut, Ghader Ghorbaniasl, Sarah Cosyns, Wouter Willaert, and Wim Ceelen. 2020. “Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles : Proof of Concept and Preclinical Validation.” ADVANCED HEALTHCARE MATERIALS 9 (16). doi:10.1002/adhm.202000655.
Vancouver
1.
Van de Sande L, Rahimi Gorji M, Giordano S, Davoli E, Matteo C, Detlefsen S, et al. Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation. ADVANCED HEALTHCARE MATERIALS. 2020;9(16).
IEEE
[1]
L. Van de Sande et al., “Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation,” ADVANCED HEALTHCARE MATERIALS, vol. 9, no. 16, 2020.
@article{8665678,
  abstract     = {{There is an increasing interest in intraperitoneal delivery of chemotherapy as an aerosol in patients with peritoneal metastasis. The currently used technology is hampered by inhomogenous drug delivery throughout the peritoneal cavity because of gravity, drag, and inertial impaction. Addition of an electrical force to aerosol particles, exerted by an electrostatic field, can improve spatial aerosol homogeneity and enhance tissue penetration. A computational fluid dynamics model shows that electrostatic precipitation (EP) results in a significantly improved aerosol distribution. Fluorescent nanoparticles (NPs) remain stable after nebulization in vitro, while EP significantly improves spatial homogeneity of NP distribution. Next, pressurized intraperitoneal chemotherapy with and without EP using NP albumin bound paclitaxel (Nab-PTX) in a novel rat model is examined. EP does not worsen the effects of CO(2)insufflation and intraperitoneal Nab-PTX on mesothelial structural integrity or the severity of peritoneal inflammation. Importantly, EP significantly enhances tissue penetration of Nab-PTX in the anatomical regions not facing the nozzle of the nebulizer. Also, the addition of EP leads to more homogenous peritoneal tissue concentrations of Nab-PTX, in parallel with higher plasma concentrations. In conclusion, EP enhances spatial homogeneity and tissue uptake after intraperitoneal nebulization of anticancer NPs.}},
  articleno    = {{2000655}},
  author       = {{Van de Sande, Leen and Rahimi Gorji, Mohammad and Giordano, Silvia and Davoli, Enrico and Matteo, Cristina and Detlefsen, Sonke and D'Herde, Katharina and Braet, Helena and Shariati, Molood and Remaut, Katrien and Xie, Fei and Debbaut, Charlotte and Ghorbaniasl, Ghader and Cosyns, Sarah and Willaert, Wouter and Ceelen, Wim}},
  issn         = {{2192-2640}},
  journal      = {{ADVANCED HEALTHCARE MATERIALS}},
  keywords     = {{computational fluid dynamics,electromotive drug administration,electrostatic precipitation,intraperitoneal drug delivery,PIPAC}},
  language     = {{eng}},
  number       = {{16}},
  pages        = {{11}},
  title        = {{Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation}},
  url          = {{http://dx.doi.org/10.1002/adhm.202000655}},
  volume       = {{9}},
  year         = {{2020}},
}

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